Compile Data Set for Download or QSAR
Found 50 with Last Name = 'ahmed' and Initial = 'z'
TargetType-1 angiotensin II receptor B(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50004154(2-Butyl-4-chloro-6-methyl-1-[2'-(1H-tetrazol-5-yl)...)copy SMILEScopy InChI
Affinity DataKi:  1nMAssay Description:Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal corticcal membrane angiotensin II receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VH5PFJPubMed
TargetType-1 angiotensin II receptor B(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50004155(2-Butyl-6-chloro-4,4-dimethyl-1-[2'-(1H-tetrazol-5...)copy SMILEScopy InChI
Affinity DataKi:  1.10nMAssay Description:Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal corticcal membrane angiotensin II receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VH5PFJPubMed
TargetType-1 angiotensin II receptor B(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50004164(2-Butyl-4-chloro-6-methyl-1-[2'-(1H-tetrazol-5-yl)...)copy SMILEScopy InChI
Affinity DataKi:  8.30nMAssay Description:Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal corticcal membrane angiotensin II receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VH5PFJPubMed
TargetType-1 angiotensin II receptor B(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50406795(Cozaar | LOSARTAN POTASSIUM)copy SMILEScopy InChI
Affinity DataKi:  9nMAssay Description:In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membra...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VH5PFJPubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University of Waterloo

Curated by ChEMBL
LigandPNGBDBM50243238(({2-Bromo-4-[40-bromo-30-(difluorosulfamoylmethyl)...)copy SMILEScopy InChI
Affinity DataKi:  24nMAssay Description:Inhibition of human PTP1B expressed in Escherichia coli BL21(DE3) cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930V2PPubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University of Waterloo

Curated by ChEMBL
LigandPNGBDBM50243240((3-((R)-2-((S)-2-((S)-2-((S)-2-((S)-2-amino-3-carb...)copy SMILEScopy InChI
Affinity DataKi:  24nMAssay Description:Inhibition of human PTP1B expressed in Escherichia coli BL21(DE3) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930V2PPubMed
TargetType-1 angiotensin II receptor B(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50004153(2-Butyl-1-(2'-carboxy-biphenyl-4-ylmethyl)-4-chlor...)copy SMILEScopy InChI
Affinity DataKi:  41nMAssay Description:Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal corticcal membrane angiotensin II receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VH5PFJPubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281270(Acetic acid (2S,3S)-5-(2-dimethylamino-ethyl)-8-me...)copy SMILEScopy InChI
Affinity DataKi:  42nMAssay Description:Displacement of [3H]-diltiazem from L-type calcium channel of guinea pig striated muscleMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN164V
TargetType-1 angiotensin II receptor B(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50004160(CHEMBL145036 | Sodium; 4'-(2-butyl-6-chloro-5-etho...)copy SMILEScopy InChI
Affinity DataKi:  58nMAssay Description:Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal corticcal membrane angiotensin II receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VH5PFJPubMed
TargetType-1 angiotensin II receptor B(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50004163(CHEMBL342287 | Sodium; 4'-(2-butyl-5-ethoxycarbony...)copy SMILEScopy InChI
Affinity DataKi:  82nMAssay Description:Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal corticcal membrane angiotensin II receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VH5PFJPubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281272((2R,3S)-5-(2-Dimethylamino-ethyl)-8-methoxy-2-(4-m...)copy SMILEScopy InChI
Affinity DataKi:  85nMAssay Description:Displacement of [3H]-diltiazem from L-type calcium channel of guinea pig striated muscleMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN164V
TargetType-1 angiotensin II receptor B(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM82258(CAS_114798-26-4 | Losartan | NSC_3961)copy SMILEScopy InChI
Affinity DataKi:  95nMAssay Description:In vitro antagonistic potency against angiotensin II receptor using [125I]- Sar,Ile8-angiotensin II as the radioligand in rat adrenal cortical membra...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VH5PFJPubMed
TargetType-1 angiotensin II receptor B(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50004162(CHEMBL145276 | Sodium; 4'-(2-butyl-5-ethoxycarbony...)copy SMILEScopy InChI
Affinity DataKi:  150nMAssay Description:Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal corticcal membrane angiotensin II receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VH5PFJPubMed
TargetType-1 angiotensin II receptor B(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50004156(2-Butyl-1-(2'-carboxy-biphenyl-4-ylmethyl)-4-(4-ch...)copy SMILEScopy InChI
Affinity DataKi:  190nMAssay Description:Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal corticcal membrane angiotensin II receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VH5PFJPubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50004704((+)-cis-Diltiazem | (2S,3S)-5-(2-(dimethylamino)et...)copy SMILEScopy InChI
Affinity DataKi:  380nMAssay Description:Displacement of [3H]-diltiazem from L-type calcium channel of guinea pig striated muscleMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50281271((2R,3S)-5-(2-Dimethylamino-ethyl)-2-(4-methoxy-phe...)copy SMILEScopy InChI
Affinity DataKi:  540nMAssay Description:Displacement of [3H]-diltiazem from L-type calcium channel of guinea pig striated muscleMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN164V
TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50000383((3R,4R)-1-(2-Dimethylamino-ethyl)-4-(4-methoxy-phe...)copy SMILEScopy InChI
Affinity DataKi:  650nMAssay Description:Displacement of [3H]-diltiazem from L-type calcium channel of guinea pig striated muscleMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN164V
TargetType-1 angiotensin II receptor B(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50004157(2-Butyl-1-(2'-carboxy-biphenyl-4-ylmethyl)-6-methy...)copy SMILEScopy InChI
Affinity DataKi:  850nMAssay Description:Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal corticcal membrane angiotensin II receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VH5PFJPubMed
TargetType-1 angiotensin II receptor B(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50004158(2-Butyl-1-(2'-carboxy-biphenyl-4-ylmethyl)-4,6-dim...)copy SMILEScopy InChI
Affinity DataKi:  990nMAssay Description:Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal corticcal membrane angiotensin II receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VH5PFJPubMed
TargetType-1 angiotensin II receptor B(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50004159(CHEMBL343622 | Sodium; 4'-(2-butyl-4-chloro-5-etho...)copy SMILEScopy InChI
Affinity DataKi:  1.43E+3nMAssay Description:Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal corticcal membrane angiotensin II receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VH5PFJPubMed
TargetType-1 angiotensin II receptor B(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50004165(CHEMBL144952 | Sodium; 4'-(2-butyl-5-ethoxycarbony...)copy SMILEScopy InChI
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of [125I]- Sar,Ile8-angiotensin II binding to rat adrenal corticcal membrane angiotensin II receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VH5PFJPubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University of Waterloo

Curated by ChEMBL
LigandPNGBDBM50243239({2-Bromo-4-[40-bromo-30-(difluorosulfamoylmethyl)b...)copy SMILEScopy InChI
Affinity DataKi:  3.30E+3nMAssay Description:Inhibition of human PTP1B expressed in Escherichia coli BL21(DE3) cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930V2PPubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University of Waterloo

Curated by ChEMBL
LigandPNGBDBM50243237([2-Bromo-4-(40-bromo-30-sulfamoylbiphenyl-4-ylmeth...)copy SMILEScopy InChI
Affinity DataKi:  1.03E+4nMAssay Description:Inhibition of human PTP1B expressed in Escherichia coli BL21(DE3) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930V2PPubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University of Waterloo

Curated by ChEMBL
LigandPNGBDBM50243236([2-Bromo-4-(40-bromo-30-sulfamoylbiphenyl-4-ylmeth...)copy SMILEScopy InChI
Affinity DataKi:  1.06E+4nMAssay Description:Inhibition of human PTP1B expressed in Escherichia coli BL21(DE3) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930V2PPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5924(BMS-387032 analog 14 | N-(5-{[(5-tert-butyl-1,3-ox...)copy SMILEScopy InChI
Affinity DataIC50: 3nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5668(2-amino-5-thio-substituted thiazole 45 | BMS-38703...)copy SMILEScopy InChI
Affinity DataIC50: 3nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5660(2-amino-5-thio-substituted thiazole 25 | 2-aminoth...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University of Waterloo

Curated by ChEMBL
LigandPNGBDBM50243184({[2-Bromo-4-(40-bromo-30-sulfamoylbiphenyl-4-ylmet...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of human PTP1B expressed in Escherichia coli BL21(DE3) cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930V2PPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5930(BMS-387032 analog 20 | N-(5-{[(5-tert-butyl-1,3-ox...)copy SMILEScopy InChI
Affinity DataIC50: 11nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5934(BMS-387032 analog 24 | N-(5-{[(5-tert-butyl-1,3-ox...)copy SMILEScopy InChI
Affinity DataIC50: 18nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5923(3-amino-N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methy...)copy SMILEScopy InChI
Affinity DataIC50: 21nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5936(4-amino-N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methy...)copy SMILEScopy InChI
Affinity DataIC50: 22nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5683(2-amino-5-thio-substituted thiazole 31 | BMS-38703...)copy SMILEScopy InChI
Affinity DataIC50: 26nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University of Waterloo

Curated by ChEMBL
LigandPNGBDBM50243238(({2-Bromo-4-[40-bromo-30-(difluorosulfamoylmethyl)...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of human PTP1B expressed in Escherichia coli BL21(DE3) cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930V2PPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5932(1-Methyl-N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]...)copy SMILEScopy InChI
Affinity DataIC50: 43nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5931(BMS-387072 | CHEMBL296468 | N-(5-{[(5-tert-butyl-1...)copy SMILEScopy InChI
Affinity DataIC50: 48nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5928((+/-)-N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]met...)copy SMILEScopy InChI
Affinity DataIC50: 50nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5926(BMS-387032 analog 16 | N-(5-{[(5-tert-butyl-1,3-ox...)copy SMILEScopy InChI
Affinity DataIC50: 50nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5933(BMS-387032 analog 23 | N-(5-{[(5-tert-butyl-1,3-ox...)copy SMILEScopy InChI
Affinity DataIC50: 74nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5929((+/-)-N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]met...)copy SMILEScopy InChI
Affinity DataIC50: 83nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5937(4-amino-N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methy...)copy SMILEScopy InChI
Affinity DataIC50: 150nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5935(BMS-387032 analog 25 | N-[5-[[[5-(1,1-Dimethylethy...)copy SMILEScopy InChI
Affinity DataIC50: 160nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company

LigandPNGBDBM5927(BMS-387032 analog 17 | N-(5-{[(5-tert-butyl-1,3-ox...)copy SMILEScopy InChI
Affinity DataIC50: 300nMpH: 8.0 T: 2°CAssay Description: The enzyme was assayed with substrate in the presence of 25 uM ATP/[gamma-33P] ATP and test compound. Dose response curves were generated to determ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26971SZPubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University of Waterloo

Curated by ChEMBL
LigandPNGBDBM50243239({2-Bromo-4-[40-bromo-30-(difluorosulfamoylmethyl)b...)copy SMILEScopy InChI
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human PTP1B expressed in Escherichia coli BL21(DE3) cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930V2PPubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University of Waterloo

Curated by ChEMBL
LigandPNGBDBM50243241(CID44560696 | PTP1B inhibitor 3 | {3-[(2R)-2-[(2S)...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PTP1B expressed in Escherichia coli BL21(DE3) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930V2PPubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University of Waterloo

Curated by ChEMBL
LigandPNGBDBM50243236([2-Bromo-4-(40-bromo-30-sulfamoylbiphenyl-4-ylmeth...)copy SMILEScopy InChI
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of human PTP1B expressed in Escherichia coli BL21(DE3) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930V2PPubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University of Waterloo

Curated by ChEMBL
LigandPNGBDBM50243237([2-Bromo-4-(40-bromo-30-sulfamoylbiphenyl-4-ylmeth...)copy SMILEScopy InChI
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of human PTP1B expressed in Escherichia coli BL21(DE3) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930V2PPubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University of Waterloo

Curated by ChEMBL
LigandPNGBDBM50075312((Difluoro-naphthalen-2-yl-methyl)-phosphonic acid ...)copy SMILEScopy InChI
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of human PTP1B expressed in Escherichia coli BL21(DE3) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930V2PPubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University of Waterloo

Curated by ChEMBL
LigandPNGBDBM50243311((S)-4-((S)-2-((S)-2-((S)-2-amino-3-carboxypropanam...)copy SMILEScopy InChI
Affinity DataIC50: 4.40E+4nMAssay Description:Inhibition of human PTP1B expressed in Escherichia coli BL21(DE3) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930V2PPubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University of Waterloo

Curated by ChEMBL
LigandPNGBDBM50072598(CHEMBL109646 | Sodium; difluoro-naphthalen-2-yl-me...)copy SMILEScopy InChI
Affinity DataIC50: 1.75E+5nMAssay Description:Inhibition of human PTP1B expressed in Escherichia coli BL21(DE3) cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930V2PPubMed