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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
4
hits in this display
Target
Serine/threonine-protein kinase MRCK alpha
(Homo sapiens (Human))
TBA
Ligand
BDBM572342
((3S)-N-cyclopropyl-1-(3- pyrimidin-5-yl-1H- pyrrol...)
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Affinity Data
Ki: 0.935nM
Assay Description:
MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
BindingDB Entry DOI:
10.7270/Q2VD72PZ
US Patent
Target
Serine/threonine-protein kinase MRCK beta
(Homo sapiens (Human))
TBA
Ligand
BDBM572342
((3S)-N-cyclopropyl-1-(3- pyrimidin-5-yl-1H- pyrrol...)
copy SMILES
Affinity Data
Ki: 3.36nM
Assay Description:
MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
BindingDB Entry DOI:
10.7270/Q2VD72PZ
US Patent
Target
Rho-associated protein kinase 2
(Homo sapiens (Human))
TBA
Ligand
BDBM572342
((3S)-N-cyclopropyl-1-(3- pyrimidin-5-yl-1H- pyrrol...)
copy SMILES
Affinity Data
Ki: 184nM
Assay Description:
MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
BindingDB Entry DOI:
10.7270/Q2VD72PZ
US Patent
Target
Rho-associated protein kinase 1
(Homo sapiens (Human))
TBA
Ligand
BDBM572342
((3S)-N-cyclopropyl-1-(3- pyrimidin-5-yl-1H- pyrrol...)
copy SMILES
Affinity Data
Ki: 357nM
Assay Description:
MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
In Depth
Details
BindingDB Entry DOI:
10.7270/Q2VD72PZ
US Patent