Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetSerine/threonine-protein kinase MRCK beta(Homo sapiens (Human))TBA

LigandBDBM572455(3-(1H-indazol-3-yl)-4-(1- piperidyl)-1H-pyrrolo[2,...)copy SMILES

Affinity DataKi:  696nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VD72PZUS Patent

TargetRho-associated protein kinase 2(Homo sapiens (Human))TBA

LigandBDBM572455(3-(1H-indazol-3-yl)-4-(1- piperidyl)-1H-pyrrolo[2,...)copy SMILES

Affinity DataKi:  1.00E+4nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair

Target InfoPDBMMDBKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VD72PZUS Patent

TargetRho-associated protein kinase 1(Homo sapiens (Human))TBA

LigandBDBM572455(3-(1H-indazol-3-yl)-4-(1- piperidyl)-1H-pyrrolo[2,...)copy SMILES

Affinity DataKi:  1.00E+4nMAssay Description:MRCKα, MRCKβ, ROCK1 and ROCK2 assays were performed using an IMAP fluorescence polarization assay format (Molecular Devices Inc.). 8-12 nM ...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VD72PZUS Patent