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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
10
hits in this display
Target
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human))
GlaxoSmithKline
Curated by
ChEMBL
Ligand
BDBM50259548
(6-(5'-chloro-2'-isobutoxy-biphenyl-2-yl)-pyridine-...)
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Affinity Data
Ki: 2.51nM
Assay Description:
Displacement of [3H]PGE2 from EP1 receptor
More data for this Ligand-Target Pair
Target Info
KEGG
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DrugBank
antibodypedia
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Ligand Info
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CHEMBL
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PC sid
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In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2N879N5
PubMed
Target
Thromboxane A2 receptor
(Homo sapiens (Human))
GlaxoSmithKline
Curated by
ChEMBL
Ligand
BDBM50259548
(6-(5'-chloro-2'-isobutoxy-biphenyl-2-yl)-pyridine-...)
copy SMILES
copy InChI
Affinity Data
Ki: 316nM
Assay Description:
Binding affinity to TP receptor
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
PC cid
PC sid
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In Depth
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Article
BindingDB Entry DOI:
10.7270/Q2N879N5
PubMed
Target
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human))
GlaxoSmithKline
Curated by
ChEMBL
Ligand
BDBM50259548
(6-(5'-chloro-2'-isobutoxy-biphenyl-2-yl)-pyridine-...)
copy SMILES
copy InChI
Affinity Data
Ki: 2.00E+3nM
Assay Description:
Activity at EP3 receptor by FLIPR method
More data for this Ligand-Target Pair
Target Info
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KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2N879N5
PubMed
Target
Prostaglandin E2 receptor EP1 subtype
(Rattus norvegicus (Rat))
GlaxoSmithKline
Curated by
ChEMBL
Ligand
BDBM50259548
(6-(5'-chloro-2'-isobutoxy-biphenyl-2-yl)-pyridine-...)
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copy InChI
Affinity Data
IC50: 12.6nM
Assay Description:
Binding affinity to rat EP1 receptor
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
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CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2N879N5
PubMed
Target
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human))
GlaxoSmithKline
Curated by
ChEMBL
Ligand
BDBM50259548
(6-(5'-chloro-2'-isobutoxy-biphenyl-2-yl)-pyridine-...)
copy SMILES
copy InChI
Affinity Data
IC50: 15.8nM
Assay Description:
Displacement of [3H]PGE2 from human EP1 receptor expressed in CHO cells
More data for this Ligand-Target Pair
Target Info
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2HT2P68
PubMed
Target
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human))
GlaxoSmithKline
Curated by
ChEMBL
Ligand
BDBM50259548
(6-(5'-chloro-2'-isobutoxy-biphenyl-2-yl)-pyridine-...)
copy SMILES
copy InChI
Affinity Data
IC50: 15.8nM
Assay Description:
Binding affinity to EP1 receptor
More data for this Ligand-Target Pair
Target Info
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2N879N5
PubMed
Target
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human))
GlaxoSmithKline
Curated by
ChEMBL
Ligand
BDBM50259548
(6-(5'-chloro-2'-isobutoxy-biphenyl-2-yl)-pyridine-...)
copy SMILES
copy InChI
Affinity Data
IC50: 16nM
Assay Description:
Binding affinity to human EP1 receptor
More data for this Ligand-Target Pair
Target Info
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2N879N5
PubMed
Target
Thromboxane A2 receptor
(Homo sapiens (Human))
GlaxoSmithKline
Curated by
ChEMBL
Ligand
BDBM50259548
(6-(5'-chloro-2'-isobutoxy-biphenyl-2-yl)-pyridine-...)
copy SMILES
copy InChI
Affinity Data
IC50: 1.58E+3nM
Assay Description:
Activity at TP receptor by FLIPR method
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2N879N5
PubMed
Target
Prostaglandin F2-alpha receptor
(Homo sapiens (Human))
GlaxoSmithKline
Curated by
ChEMBL
Ligand
BDBM50259548
(6-(5'-chloro-2'-isobutoxy-biphenyl-2-yl)-pyridine-...)
copy SMILES
copy InChI
Affinity Data
IC50: 1.00E+4nM
Assay Description:
Activity at PGF2alpha receptor by FLIPR method
More data for this Ligand-Target Pair
Target Info
PDB
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antibodypedia
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CHEMBL
PC cid
PC sid
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In Depth
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Article
BindingDB Entry DOI:
10.7270/Q2N879N5
PubMed
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
GlaxoSmithKline
Curated by
ChEMBL
Ligand
BDBM50259548
(6-(5'-chloro-2'-isobutoxy-biphenyl-2-yl)-pyridine-...)
copy SMILES
copy InChI
Affinity Data
IC50: 3.16E+4nM
Assay Description:
Displacement of [3H]dofetilide from human ERG receptor by FLIPR method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2N879N5
PubMed