Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 11 hits in this display   

TargetProstaglandin D2 receptor(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50277632((S)-2-(9-(3,4-dichlorophenylthio)-1-isopropyl-7,8-...)copy SMILEScopy InChI
Affinity DataKi:  0.640nMAssay Description:Displacement of radioligand from human recombinant DP1 receptor expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W9593RPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50277632((S)-2-(9-(3,4-dichlorophenylthio)-1-isopropyl-7,8-...)copy SMILEScopy InChI
Affinity DataKi:  233nMAssay Description:Binding affinity to CRTH2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W9593RPubMed
TargetProstaglandin E2 receptor EP3 subtype(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50277632((S)-2-(9-(3,4-dichlorophenylthio)-1-isopropyl-7,8-...)copy SMILEScopy InChI
Affinity DataKi:  710nMAssay Description:Binding affinity to EP3 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W9593RPubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50277632((S)-2-(9-(3,4-dichlorophenylthio)-1-isopropyl-7,8-...)copy SMILEScopy InChI
Affinity DataKi:  5.04E+3nMAssay Description:Displacement of radioligand from human recombinant TP receptor expressed in HEK293 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W9593RPubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50277632((S)-2-(9-(3,4-dichlorophenylthio)-1-isopropyl-7,8-...)copy SMILEScopy InChI
Affinity DataKi:  6.55E+3nMAssay Description:Binding affinity to EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W9593RPubMed
TargetProstaglandin E2 receptor EP2 subtype(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50277632((S)-2-(9-(3,4-dichlorophenylthio)-1-isopropyl-7,8-...)copy SMILEScopy InChI
Affinity DataKi:  7.32E+3nMAssay Description:Binding affinity to EP2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W9593RPubMed
TargetProstaglandin F2-alpha receptor(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50277632((S)-2-(9-(3,4-dichlorophenylthio)-1-isopropyl-7,8-...)copy SMILEScopy InChI
Affinity DataKi:  2.57E+4nMAssay Description:Binding affinity to FP receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W9593RPubMed
TargetProstacyclin receptor(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50277632((S)-2-(9-(3,4-dichlorophenylthio)-1-isopropyl-7,8-...)copy SMILEScopy InChI
Affinity DataKi: >2.57E+4nMAssay Description:Binding affinity to IP receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W9593RPubMed
TargetProstaglandin E2 receptor EP1 subtype(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50277632((S)-2-(9-(3,4-dichlorophenylthio)-1-isopropyl-7,8-...)copy SMILEScopy InChI
Affinity DataKi:  2.85E+4nMAssay Description:Binding affinity to EP1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W9593RPubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50277632((S)-2-(9-(3,4-dichlorophenylthio)-1-isopropyl-7,8-...)copy SMILEScopy InChI
Affinity DataIC50: 0.220nMAssay Description:Antagonist activity at DP1 in washed human platelet assessed as inhibition of PGD2-induced [125I]cAMP production preincubated 10 mins before PGD2 cha...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W9593RPubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50277632((S)-2-(9-(3,4-dichlorophenylthio)-1-isopropyl-7,8-...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Antagonist activity at DP1 in human platelet-rich plasma assessed as inhibition of PGD2-induced [125I]cAMP production preincubated 10 mins before PGD...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W9593RPubMed