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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
6
hits in this display
Target
Melanocortin receptor 4
(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50253736
(CHEMBL506272 | N-((R)-3-(4-Fluorophenyl)-1-((S)-4-...)
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Affinity Data
Ki: 4nM
Assay Description:
Displacement of europium-labeled NDP-alpha-MSH from human MC4R expressed in HEK293 cells
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2DV1JQC
PubMed
Target
Melanocortin receptor 3
(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50253736
(CHEMBL506272 | N-((R)-3-(4-Fluorophenyl)-1-((S)-4-...)
copy SMILES
copy InChI
Affinity Data
Ki: 128nM
Assay Description:
Displacement of europium-labeled NDP-alpha-MSH from human MC3R expressed in HEK293 cells
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2DV1JQC
PubMed
Target
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50253736
(CHEMBL506272 | N-((R)-3-(4-Fluorophenyl)-1-((S)-4-...)
copy SMILES
copy InChI
Affinity Data
Ki: 361nM
Assay Description:
Agonist activity at human MC1R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2DV1JQC
PubMed
Target
Melanocortin receptor 4
(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50253736
(CHEMBL506272 | N-((R)-3-(4-Fluorophenyl)-1-((S)-4-...)
copy SMILES
copy InChI
Affinity Data
EC50: 2nM
Assay Description:
Agonist activity at human MC4R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2DV1JQC
PubMed
Target
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50253736
(CHEMBL506272 | N-((R)-3-(4-Fluorophenyl)-1-((S)-4-...)
copy SMILES
copy InChI
Affinity Data
EC50: 104nM
Assay Description:
Agonist activity at human MC1R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2DV1JQC
PubMed
Target
Melanocortin receptor 3
(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals
Curated by
ChEMBL
Ligand
BDBM50253736
(CHEMBL506272 | N-((R)-3-(4-Fluorophenyl)-1-((S)-4-...)
copy SMILES
copy InChI
Affinity Data
EC50: 25nM
Assay Description:
Agonist activity at human MC3R expressed in HEK293 cells assessed as effect on CRE-driven luminescence by luciferase reporter gene assay
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2DV1JQC
PubMed