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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
7
hits in this display
Target
Melanocortin receptor 4
(Homo sapiens (Human))
University of Arizona
Curated by
ChEMBL
Ligand
BDBM50268793
(Ac-Nle-c[Asp-His-DPhe-trans-4-guanidinyl-Pro-Trp-L...)
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Affinity Data
IC50: 50nM
Assay Description:
Displacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC4R expressed in HEK293 cells
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2D21ZJ5
PubMed
Target
Melanocortin receptor 5
(Homo sapiens (Human))
University of Arizona
Curated by
ChEMBL
Ligand
BDBM50268793
(Ac-Nle-c[Asp-His-DPhe-trans-4-guanidinyl-Pro-Trp-L...)
copy SMILES
copy InChI
Affinity Data
IC50: 590nM
Assay Description:
Displacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC5R expressed in HEK293 cells
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2D21ZJ5
PubMed
Target
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human))
University of Arizona
Curated by
ChEMBL
Ligand
BDBM50268793
(Ac-Nle-c[Asp-His-DPhe-trans-4-guanidinyl-Pro-Trp-L...)
copy SMILES
copy InChI
Affinity Data
IC50: 3.50E+3nM
Assay Description:
Agonist activity at human MC1R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2D21ZJ5
PubMed
Target
Melanocortin receptor 5
(Homo sapiens (Human))
University of Arizona
Curated by
ChEMBL
Ligand
BDBM50268793
(Ac-Nle-c[Asp-His-DPhe-trans-4-guanidinyl-Pro-Trp-L...)
copy SMILES
copy InChI
Affinity Data
EC50: 2.50E+3nM
Assay Description:
Agonist activity at human MC5R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2D21ZJ5
PubMed
Target
Melanocortin receptor 4
(Homo sapiens (Human))
University of Arizona
Curated by
ChEMBL
Ligand
BDBM50268793
(Ac-Nle-c[Asp-His-DPhe-trans-4-guanidinyl-Pro-Trp-L...)
copy SMILES
copy InChI
Affinity Data
EC50: 43nM
Assay Description:
Agonist activity at human MC4R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2D21ZJ5
PubMed
Target
Melanocortin receptor 3
(Homo sapiens (Human))
University of Arizona
Curated by
ChEMBL
Ligand
BDBM50268793
(Ac-Nle-c[Asp-His-DPhe-trans-4-guanidinyl-Pro-Trp-L...)
copy SMILES
copy InChI
Affinity Data
EC50: <0.100nM
Assay Description:
Agonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2D21ZJ5
PubMed
Target
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human))
University of Arizona
Curated by
ChEMBL
Ligand
BDBM50268793
(Ac-Nle-c[Asp-His-DPhe-trans-4-guanidinyl-Pro-Trp-L...)
copy SMILES
copy InChI
Affinity Data
EC50: <0.100nM
Assay Description:
Agonist activity at human MC1R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2D21ZJ5
PubMed