Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 5 hits in this display   

TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315678(((3R,4S)-1-butyl-4-(2,4-difluorophenyl)pyrrolidin-...)copy SMILEScopy InChI
Affinity DataKi:  233nMAssay Description:Displacement of [3H] melanocortin-2 from human recombinant MC4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315678(((3R,4S)-1-butyl-4-(2,4-difluorophenyl)pyrrolidin-...)copy SMILEScopy InChI
Affinity DataEC50: >5.72E+3nMAssay Description:Agonist activity at human recombinant MC3 receptor expressed in CHO cells assessed as cAMP accumulation by enzyme fragment complementation assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315678(((3R,4S)-1-butyl-4-(2,4-difluorophenyl)pyrrolidin-...)copy SMILEScopy InChI
Affinity DataEC50:  1.10E+3nMAssay Description:Agonist activity at human recombinant MC1 receptor expressed in HEK293 cells assessed as cAMP accumulation by enzyme fragment complementation assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315678(((3R,4S)-1-butyl-4-(2,4-difluorophenyl)pyrrolidin-...)copy SMILEScopy InChI
Affinity DataEC50:  105nMAssay Description:Agonist activity at human recombinant MC4 receptor expressed in CHO cells by cAMP responsive beta lactamase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50315678(((3R,4S)-1-butyl-4-(2,4-difluorophenyl)pyrrolidin-...)copy SMILEScopy InChI
Affinity DataEC50:  1.43E+3nMAssay Description:Agonist activity at human recombinant MC5 receptor expressed in HEK293 cells assessed as cAMP accumulation by beta lactamase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3M4TPubMed