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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
4
hits in this display
Target
Nitric oxide synthase, brain
(Homo sapiens (Human))
Instituto de Química Médica
Curated by
ChEMBL
Ligand
BDBM50058469
(1-(4-Chloro-phenyl)-2-ethyl-isothiourea; hydrochlo...)
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Affinity Data
Ki: 140nM
Assay Description:
Inhibition of nNOS (unknown origin) assessed as conversion of L-[3H]arginine to L-[3H]citrulline
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2611040
PubMed
Target
Nitric oxide synthase, brain
(Homo sapiens (Human))
Instituto de Química Médica
Curated by
ChEMBL
Ligand
BDBM50058469
(1-(4-Chloro-phenyl)-2-ethyl-isothiourea; hydrochlo...)
copy SMILES
copy InChI
Affinity Data
Ki: 140nM
Assay Description:
Inhibitory activity against human neuronal nitric oxide synthase in brain (nNOS).
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2SJ1M94
PubMed
Target
Nitric oxide synthase, endothelial
(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by
ChEMBL
Ligand
BDBM50058469
(1-(4-Chloro-phenyl)-2-ethyl-isothiourea; hydrochlo...)
copy SMILES
copy InChI
Affinity Data
Ki: 900nM
Assay Description:
Inhibitory activity against human vascular endothelial nitric oxide synthase.
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2SJ1M94
PubMed
Target
Nitric oxide synthase, inducible
(Homo sapiens (Human))
Glaxo Wellcome Research and Development
Curated by
ChEMBL
Ligand
BDBM50058469
(1-(4-Chloro-phenyl)-2-ethyl-isothiourea; hydrochlo...)
copy SMILES
copy InChI
Affinity Data
Ki: 4.20E+3nM
Assay Description:
Inhibitory activity against human inducible nitric oxide synthase (iNOS).
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2SJ1M94
PubMed