Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 10 hits in this display   

TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333868((R)-2-(3-fluoro-7-(4-fluoro-N-methylphenylsulfonam...)copy SMILEScopy InChI
Affinity DataKi:  1.10nMAssay Description:Binding affinity to human recombinant CRTH2 receptor by cell based radioligand equilibrium competition assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2959HTHPubMed
TargetProstaglandin D2 receptor(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333868((R)-2-(3-fluoro-7-(4-fluoro-N-methylphenylsulfonam...)copy SMILEScopy InChI
Affinity DataKi:  248nMAssay Description:Binding affinity to prostanoid DP1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2959HTHPubMed
TargetThromboxane A2 receptor(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333868((R)-2-(3-fluoro-7-(4-fluoro-N-methylphenylsulfonam...)copy SMILEScopy InChI
Affinity DataKi:  727nMAssay Description:Binding affinity to thromboxane receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2959HTHPubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333868((R)-2-(3-fluoro-7-(4-fluoro-N-methylphenylsulfonam...)copy SMILEScopy InChI
Affinity DataKi:  3.50E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2959HTHPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333868((R)-2-(3-fluoro-7-(4-fluoro-N-methylphenylsulfonam...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Antagonist activity at CRTH2 receptor in human whole blood assessed as inhibition of DK-PGD2-induced eosinophils shape changeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2959HTHPubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333868((R)-2-(3-fluoro-7-(4-fluoro-N-methylphenylsulfonam...)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Antagonist activity at human recombinant CRTH2 receptor expressed in HEK293 cells assessed as inhibition of DK-PGD2-induced intracellular cAMP format...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2959HTHPubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333868((R)-2-(3-fluoro-7-(4-fluoro-N-methylphenylsulfonam...)copy SMILEScopy InChI
Affinity DataIC50: 1.36E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2959HTHPubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333868((R)-2-(3-fluoro-7-(4-fluoro-N-methylphenylsulfonam...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2959HTHPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333868((R)-2-(3-fluoro-7-(4-fluoro-N-methylphenylsulfonam...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2959HTHPubMed
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50333868((R)-2-(3-fluoro-7-(4-fluoro-N-methylphenylsulfonam...)copy SMILEScopy InChI
Affinity DataEC50: >3.00E+4nMAssay Description:Induction of pregnane X receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2959HTHPubMed