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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
10
hits in this display
Target
Prostaglandin D2 receptor 2
(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research
Curated by
ChEMBL
Ligand
BDBM50333868
((R)-2-(3-fluoro-7-(4-fluoro-N-methylphenylsulfonam...)
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Affinity Data
Ki: 1.10nM
Assay Description:
Binding affinity to human recombinant CRTH2 receptor by cell based radioligand equilibrium competition assay
More data for this Ligand-Target Pair
Target Info
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Article
BindingDB Entry DOI:
10.7270/Q2959HTH
PubMed
Target
Prostaglandin D2 receptor
(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research
Curated by
ChEMBL
Ligand
BDBM50333868
((R)-2-(3-fluoro-7-(4-fluoro-N-methylphenylsulfonam...)
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Affinity Data
Ki: 248nM
Assay Description:
Binding affinity to prostanoid DP1 receptor
More data for this Ligand-Target Pair
Target Info
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Article
BindingDB Entry DOI:
10.7270/Q2959HTH
PubMed
Target
Thromboxane A2 receptor
(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research
Curated by
ChEMBL
Ligand
BDBM50333868
((R)-2-(3-fluoro-7-(4-fluoro-N-methylphenylsulfonam...)
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Affinity Data
Ki: 727nM
Assay Description:
Binding affinity to thromboxane receptor
More data for this Ligand-Target Pair
Target Info
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In Depth
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Article
BindingDB Entry DOI:
10.7270/Q2959HTH
PubMed
Target
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research
Curated by
ChEMBL
Ligand
BDBM50333868
((R)-2-(3-fluoro-7-(4-fluoro-N-methylphenylsulfonam...)
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Affinity Data
Ki: 3.50E+4nM
Assay Description:
Inhibition of human ERG
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
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UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2959HTH
PubMed
Target
Prostaglandin D2 receptor 2
(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research
Curated by
ChEMBL
Ligand
BDBM50333868
((R)-2-(3-fluoro-7-(4-fluoro-N-methylphenylsulfonam...)
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copy InChI
Affinity Data
IC50: 1.40nM
Assay Description:
Antagonist activity at CRTH2 receptor in human whole blood assessed as inhibition of DK-PGD2-induced eosinophils shape change
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2959HTH
PubMed
Target
Prostaglandin D2 receptor 2
(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research
Curated by
ChEMBL
Ligand
BDBM50333868
((R)-2-(3-fluoro-7-(4-fluoro-N-methylphenylsulfonam...)
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copy InChI
Affinity Data
IC50: 2.60nM
Assay Description:
Antagonist activity at human recombinant CRTH2 receptor expressed in HEK293 cells assessed as inhibition of DK-PGD2-induced intracellular cAMP format...
More data for this Ligand-Target Pair
Target Info
PDB
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antibodypedia
GoogleScholar
Ligand Info
CHEMBL
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PC sid
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In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2959HTH
PubMed
Target
Cytochrome P450 2C9
(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research
Curated by
ChEMBL
Ligand
BDBM50333868
((R)-2-(3-fluoro-7-(4-fluoro-N-methylphenylsulfonam...)
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Affinity Data
IC50: 1.36E+4nM
Assay Description:
Inhibition of CYP2C9
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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antibodypedia
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Ligand Info
CHEMBL
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PC sid
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In Depth
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Article
BindingDB Entry DOI:
10.7270/Q2959HTH
PubMed
Target
Cytochrome P450 2D6
(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research
Curated by
ChEMBL
Ligand
BDBM50333868
((R)-2-(3-fluoro-7-(4-fluoro-N-methylphenylsulfonam...)
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Affinity Data
IC50: 5.00E+4nM
Assay Description:
Inhibition of CYP2D6
More data for this Ligand-Target Pair
Target Info
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In Depth
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Article
BindingDB Entry DOI:
10.7270/Q2959HTH
PubMed
Target
Cytochrome P450 3A4
(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research
Curated by
ChEMBL
Ligand
BDBM50333868
((R)-2-(3-fluoro-7-(4-fluoro-N-methylphenylsulfonam...)
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Affinity Data
IC50: 5.00E+4nM
Assay Description:
Inhibition of CYP3A4
More data for this Ligand-Target Pair
Target Info
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MMDB
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antibodypedia
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Ligand Info
CHEMBL
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In Depth
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Article
BindingDB Entry DOI:
10.7270/Q2959HTH
PubMed
Target
Nuclear receptor subfamily 1 group I member 2
(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research
Curated by
ChEMBL
Ligand
BDBM50333868
((R)-2-(3-fluoro-7-(4-fluoro-N-methylphenylsulfonam...)
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Affinity Data
EC50: >3.00E+4nM
Assay Description:
Induction of pregnane X receptor
More data for this Ligand-Target Pair
Target Info
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Ligand Info
CHEMBL
PC cid
PC sid
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In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2959HTH
PubMed