Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 12 hits in this display   

TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
NeurAxon Inc.

Curated by ChEMBL
LigandPNGBDBM106722(CHEMBL2036264 | US8586620, 114)copy SMILEScopy InChI
Affinity DataIC50: 550nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5H2VPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
NeurAxon Inc.

Curated by ChEMBL
LigandPNGBDBM106722(CHEMBL2036264 | US8586620, 114)copy SMILEScopy InChI
Affinity DataIC50: 550nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5H2VPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
NeurAxon Inc.

Curated by ChEMBL
LigandPNGBDBM106722(CHEMBL2036264 | US8586620, 114)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+3nMAssay Description:Displacement of [3H]nisoxetine from human NET expressed in CHO cells after 120 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5H2VPubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
NeurAxon, Inc.

US Patent
LigandPNGBDBM106722(CHEMBL2036264 | US8586620, 114)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMAssay Description:Enzyme assay using recombinant human inducible NOS (iNOS), human endothelial constitutive NOS (eNOS) or human neuronal constitutive NOS (nNOS).More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2348J0KUS Patent
TargetNitric oxide synthase, brain(Homo sapiens (Human))
NeurAxon, Inc.

US Patent
LigandPNGBDBM106722(CHEMBL2036264 | US8586620, 114)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human nNOS expressed in baculovirus-infected insect sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline preincubat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5H2VPubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
NeurAxon, Inc.

US Patent
LigandPNGBDBM106722(CHEMBL2036264 | US8586620, 114)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human nNOS expressed in baculovirus-infected insect sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline preincubat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5H2VPubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
NeurAxon, Inc.

US Patent
LigandPNGBDBM106722(CHEMBL2036264 | US8586620, 114)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human nNOS expressed in baculovirus-infected insect sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline preincubat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5H2VPubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
NeurAxon Inc.

Curated by ChEMBL
LigandPNGBDBM106722(CHEMBL2036264 | US8586620, 114)copy SMILEScopy InChI
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of human iNOS expressed in baculovirus-infected insect sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline preincubat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5H2VPubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
NeurAxon Inc.

Curated by ChEMBL
LigandPNGBDBM106722(CHEMBL2036264 | US8586620, 114)copy SMILEScopy InChI
Affinity DataIC50: 4.71E+4nMAssay Description:Inhibition of human eNOS expressed in baculovirus-infected insect sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline preincubat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5H2VPubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
NeurAxon Inc.

Curated by ChEMBL
LigandPNGBDBM106722(CHEMBL2036264 | US8586620, 114)copy SMILEScopy InChI
Affinity DataIC50: 4.71E+4nMAssay Description:Inhibition of human eNOS expressed in baculovirus-infected insect sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline preincubat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5H2VPubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
NeurAxon Inc.

Curated by ChEMBL
LigandPNGBDBM106722(CHEMBL2036264 | US8586620, 114)copy SMILEScopy InChI
Affinity DataIC50: 5.14E+4nMAssay Description:Inhibition of human eNOS expressed in baculovirus-infected insect sf9 cells assessed as conversion of [3H]-L-arginine to [3H]-L-citrulline preincubat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5H2VPubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
NeurAxon Inc.

Curated by ChEMBL
LigandPNGBDBM106722(CHEMBL2036264 | US8586620, 114)copy SMILEScopy InChI
Affinity DataIC50: 5.14E+4nMAssay Description:Enzyme assay using recombinant human inducible NOS (iNOS), human endothelial constitutive NOS (eNOS) or human neuronal constitutive NOS (nNOS).More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2348J0KUS Patent