Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 32 hits in this display   

TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Nycomed GmbH

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Inhibition of recombinant GST-tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC90BWPubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Nycomed GmbH

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4X29PubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Nycomed GmbH

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Inhibition of recombinant GST- tagged full-length ITK expressed in baculovirus expression system after 30 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4X29PubMed
TargetAurora kinase A(Homo sapiens (Human))
Nycomed GmbH

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 190nMAssay Description:Inhibition of Aurora AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4X29PubMed
TargetAurora kinase B(Homo sapiens (Human))
Nycomed GmbH

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 270nMAssay Description:Inhibition of Aurora BMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4X29PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Nycomed GmbH

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 310nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4X29PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Nycomed GmbH

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 1.31E+3nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4X29PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Nycomed GmbH

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 1.45E+3nMAssay Description:Inhibition of CDK4/Cyclin D1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4X29PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Nycomed GmbH

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 2.45E+3nMAssay Description:Inhibition of MEK-1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4X29PubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Nycomed GmbH

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of PDGFR-betaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4X29PubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Nycomed GmbH

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 3.22E+3nMAssay Description:Inhibition of NEK-2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4X29PubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Nycomed GmbH

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 3.82E+3nMAssay Description:Inhibition of SAKMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4X29PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Nycomed GmbH

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4X29PubMed
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 5.23E+3nMAssay Description:Inhibition of CDK1/Cyclin BMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4X29PubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nycomed GmbH

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 5.38E+3nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4X29PubMed
TargetFocal adhesion kinase 1(Homo sapiens (Human))
Nycomed GmbH

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 5.49E+3nMAssay Description:Inhibition of FAKMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4X29PubMed
TargetWee1-like protein kinase(Homo sapiens (Human))
Nycomed GmbH

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 5.72E+3nMAssay Description:Inhibition of WEE1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4X29PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Nycomed GmbH

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 5.94E+3nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4X29PubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Nycomed GmbH

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 7.41E+3nMAssay Description:Inhibition of CDK5/p25More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4X29PubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Nycomed GmbH

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 7.68E+3nMAssay Description:Inhibition of ABL1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4X29PubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Nycomed GmbH

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 8.75E+3nMAssay Description:Inhibition of TTKMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4X29PubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Nycomed GmbH

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 2.24E+4nMAssay Description:Inhibition of PKC-thetaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4X29PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Nycomed GmbH

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of IKK-betaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4X29PubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Nycomed GmbH

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PKC-beta1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4X29PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Nycomed GmbH

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of p38-alphaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4X29PubMed
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
Nycomed GmbH

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CK2-alpha1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4X29PubMed
TargetDeath-associated protein kinase 1(Homo sapiens (Human))
Nycomed GmbH

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of DAPK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4X29PubMed
TargetSerine/threonine-protein kinase MRCK beta(Homo sapiens (Human))
Nycomed GmbH

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CDC42 BpBMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4X29PubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Nycomed GmbH

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of B-rafMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4X29PubMed
TargetLymphokine-activated killer T-cell-originated protein kinase(Homo sapiens (Human))
Nycomed GmbH

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PBKMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4X29PubMed
TargetSerine/threonine-protein kinase PAK 2(Homo sapiens (Human))
Nycomed GmbH

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PAK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4X29PubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Nycomed GmbH

Curated by ChEMBL
LigandPNGBDBM50331277(3-(6-methoxy-1H-indol-2-yl)-1H-pyrazolo[4,3-b]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PLK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JD4X29PubMed