Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 6 hits in this display   

TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent
LigandPNGBDBM284001(E27 | US10023564, Example 27)copy SMILES
Affinity DataIC50: 320nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2V126V5US Patent
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent
LigandPNGBDBM284001(E27 | US10023564, Example 27)copy SMILES
Affinity DataIC50: 400nMAssay Description:Inhibition of GRK2 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z1868PubMed
TargetG protein-coupled receptor kinase 5(Homo sapiens (Human))
THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent
LigandPNGBDBM284001(E27 | US10023564, Example 27)copy SMILES
Affinity DataIC50: 2.40E+3nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2V126V5US Patent
TargetG protein-coupled receptor kinase 5(Homo sapiens (Human))
THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent
LigandPNGBDBM284001(E27 | US10023564, Example 27)copy SMILES
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of GRK5 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z1868PubMed
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent
LigandPNGBDBM284001(E27 | US10023564, Example 27)copy SMILES
Affinity DataIC50: 1.40E+4nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2V126V5US Patent
TargetRhodopsin kinase GRK1(Homo sapiens (Human))
THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent
LigandPNGBDBM284001(E27 | US10023564, Example 27)copy SMILES
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of GRK1 (unknown origin) preincubated for 10 mins followed by peptide substrate and ATP addition measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z1868PubMed