Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 34 hits in this display   

TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataKi:  2.30nMAssay Description:Inhibition of [3H]AVP binding to recombinant human vasopressin V2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN679WPubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataKi:  23nMAssay Description:Inhibition of 1 nM AVP-induced cAMP accumulation in cells expressing human vasopressin V2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN679WPubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataKi:  44nMAssay Description:Inhibition of [3H]AVP binding to recombinant human vasopressin V2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN679WPubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataKi:  90nMAssay Description:Inhibition of [3H]-Arg-vasopressin binding to recombinant human vasopressin V2 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22N51NMPubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataKi:  6.00E+3nMAssay Description:Inhibition of 1 nM AVP-induced calcium mobilisation in cells expressing human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN679WPubMed
TargetVasopressin V2 receptor(Rattus norvegicus (Rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Displacement of P[3H]-AVP from isolated rat kidney medullary V2 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23B5ZBZPubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of [3H]-AVP binding to human V2 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C828WHPubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Displacement of [3H]-AVP from human V2 receptor expressed in murine fibroblast cell line (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CC0ZT5PubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Displacement of [3H]-AVP from human vasopressin V2-receptor expressed in murine fibroblast cell (LV2) membranesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24M93RKPubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:In vitro inhibition of [3H]-AVP binding to human V2 receptor from murine fibroblast cell line (LV2)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2736Q34PubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Displacement of [3H]AVP from human vasopressin V2 receptor expressed in mouse LV2 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9J05PubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:In vitro binding affinity to human V2 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2X34WP8PubMed
TargetVasopressin V2 receptor(Rattus norvegicus (Rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Binding affinity to rat V2 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2X34WP8PubMed
TargetVasopressin V2 receptor(Rattus norvegicus (Rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Displacement of [3H]-AVP from vasopressin V2 receptor of rat kidney medulla.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CC0ZT5PubMed
TargetVasopressin V2 receptor(Rattus norvegicus (Rat))
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Inhibition of [3H]-AVP binding to Dawley rat kidney medullary vasopressin V2 receptor.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SF2VJHPubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]-AVP from human V2 receptors expressed in HEK-293 cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ07PVPubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of [3H]-Arg-vasopressin binding to recombinant human vasopressin V2 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22N51NMPubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T72H5PPubMed
TargetVasopressin V1a receptor(RAT)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataIC50: 82nMAssay Description:Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23B5ZBZPubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataIC50: 91nMAssay Description:Inhibitory activity of the human V2 receptor was assessed by the accumulation of cAMP in transfected HEK-293 cells.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ07PVPubMed
TargetVasopressin V2 receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataIC50: 91nMAssay Description:Antagonist activity at human vasopressin V2 receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced cAMP levelsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T72H5PPubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataIC50: 124nMAssay Description:Displacement of [3H]Manning ligand from human vasopressin V1a receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9J05PubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:Binding affinity towards human V1a receptorsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ07PVPubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:Inhibition of [3H]-Arg-vasopressin binding to recombinant human vasopressin V1a receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22N51NMPubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:Displacement of [3H]-Arg-vasopressin from human recombinant vasopressin V1a receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T72H5PPubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:Inhibitory concentration against [3H]-AVP binding to human vasopressin V1a receptor More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C828WHPubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataIC50: 230nMAssay Description:Displacement of [3H]-AVP from vasopressin receptor (V1a) from human platelet membranes.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CC0ZT5PubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataIC50: 230nMAssay Description:In vitro binding affinity to human V1a receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2X34WP8PubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataIC50: 230nMAssay Description:In vitro inhibition of [3H]- AVP binding to V1a receptor from human platelet membraneMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2736Q34PubMed
TargetVasopressin V1a receptor(RAT)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataIC50: 340nMAssay Description:Displacement of (Phe-3,4,5-H) Vasopressin from V1a recptor from rat liver membranes.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CC0ZT5PubMed
TargetVasopressin V1a receptor(RAT)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataIC50: 340nMAssay Description:In vitro binding affinity for rat V1a receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2X34WP8PubMed
TargetVasopressin V1a receptor(RAT)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataIC50: 410nMAssay Description:Inhibition of [3H]-AVP binding to Dawley rat hepatic vasopressin V1a receptor.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SF2VJHPubMed
TargetOxytocin receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataIC50: 519nMAssay Description:Displacement of [3H]oxytocin from human oxytocin receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9J05PubMed
TargetVasopressin V1a receptor(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50065115(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMAssay Description:Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of Arg-vasopressin-induced intracllular calciu...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T72H5PPubMed