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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
6
hits in this display
Target
L-lactate dehydrogenase A chain
(Homo sapiens (Human))
TBA
Ligand
BDBM50547002
(CHEMBL4753379 | US11247971, Cmpd ID 449 | US117521...)
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Affinity Data
IC50: 40nM
Assay Description:
Inhibition of recombinant human LDHA using sodium pyruvate as substrate preincubated for 5 mins followed by diaphorase/resazurin addition and measure...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2057KJ6
PubMed
PDB
3D Structure (crystal)
Target
L-lactate dehydrogenase B chain
(Homo sapiens (Human))
TBA
Ligand
BDBM50547002
(CHEMBL4753379 | US11247971, Cmpd ID 449 | US117521...)
copy SMILES
Affinity Data
IC50: 100nM
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
In Depth
Details
BindingDB Entry DOI:
10.7270/Q2G73JVB
Target
L-lactate dehydrogenase A chain
(Homo sapiens (Human))
TBA
Ligand
BDBM50547002
(CHEMBL4753379 | US11247971, Cmpd ID 449 | US117521...)
copy SMILES
Affinity Data
IC50: 119nM
Assay Description:
Inhibition of GS[HiBiT]GS-tagged LDHA (unknown origin) expressed in HEK-293T cells measured after 1 hr by CESTA
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2057KJ6
PubMed
PDB
3D Structure (crystal)
Target
L-lactate dehydrogenase A chain
(Homo sapiens (Human))
TBA
Ligand
BDBM50547002
(CHEMBL4753379 | US11247971, Cmpd ID 449 | US117521...)
copy SMILES
Affinity Data
IC50: 367nM
Assay Description:
Inhibition of LDHA in human MIA PaCa-2 cells assessed as decrease in lactate production incubated for 2 hrs by lactate oxidase-coupled fluorescence b...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2057KJ6
PubMed
PDB
3D Structure (crystal)
Target
L-lactate dehydrogenase A chain
(Homo sapiens (Human))
TBA
Ligand
BDBM50547002
(CHEMBL4753379 | US11247971, Cmpd ID 449 | US117521...)
copy SMILES
Affinity Data
IC50: 760nM
Assay Description:
Inhibition of LDHA in human A673 cells assessed as decrease in lactate production incubated for 2 hrs by lactate oxidase-coupled fluorescence based a...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2057KJ6
PubMed
PDB
3D Structure (crystal)
Target
L-lactate dehydrogenase A chain
(Homo sapiens (Human))
TBA
Ligand
BDBM50547002
(CHEMBL4753379 | US11247971, Cmpd ID 449 | US117521...)
copy SMILES
Affinity Data
Kd: 0.0634nM
Assay Description:
Binding affinity to human His-tagged LDHA by SPR analysis
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
PDB
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2057KJ6
PubMed
PDB
3D Structure (crystal)