Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 42 hits in this display   

TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))TBA
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu3 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataKi:  3.04nMAssay Description:Binding affinity towards metabotropic glutamate receptor 3 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataKi:  3.13nMAssay Description:Binding affinity towards metabotropic glutamate receptor 2 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H]-LY459477 from recombinant human mGlu2 receptor expressed in hamster AV12 cell membranes co-expressing rat EAAT1 incubated for 90...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))TBA
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataKi:  14nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 3 (mGluR-3).More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataKi:  21nMAssay Description:Antagonist potency against cloned Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 7(Rattus norvegicus (Rat))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataKi:  110nMAssay Description:Binding affinity towards metabotropic glutamate receptor 7 of rat expressed in CHO cells was determined by using [3H]-MGS0008More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataKi:  170nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ090QPubMed
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataKi:  990nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 7 (mGluR-7).More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataKi:  6.80E+3nMAssay Description:Agonist potency against cloned human metabotropic glutamate receptor 1More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataKi:  8.20E+3nMAssay Description:Agonist potency against cloned metabotropic glutamate receptor 5More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataKi:  2.20E+4nMAssay Description:Agonist potency against cloned human Metabotropic glutamate receptor 4 (mGluR-4)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DZ090QPubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))TBA
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataIC50: 2.80nMAssay Description:Antagonist activity at human recombinant mGlu3 stably expressed in golden hamster AV12 cell membrane co-expressing Galpha15 assessed as assessed as r...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataIC50: 2.90nMAssay Description:Displacement of [3H]-MGS0008 from mGluR2 expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))TBA
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataIC50: 7.70nMAssay Description:Antagonist activity at human recombinant mGlu3 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataIC50: 7.80nMAssay Description:Antagonist activity at human recombinant mGlu2 receptor stably expressed in golden hamster AV12 cell membrane co-expressing Galpha15 assessed as asse...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))TBA
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))TBA
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Antagonist activity at human mGLUR3 expressed in RGT cells assessed as inhibition of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid-induced inhibi...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataIC50: 14.2nMAssay Description:Concentration required to inhibit metabotropic glutamate receptor 3 activity of rat expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Antagonistic activity against metabotropic glutamate receptor 3 (mGluR3) was evaluatedMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Compound was evaluated for the inhibition of binding of [3H]glutamate against rat recombinant mGluR3 receptors expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Antagonist activity at human mGLUR2 expressed in RGT cells assessed as inhibition of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid-induced inhibi...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 2More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataIC50: 23.2nMAssay Description:Concentration required to inhibit metabotropic glutamate receptor 2 activity of rat expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataIC50: 27nMAssay Description:Antagonist activity at human recombinant mGlu2 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataIC50: 170nMAssay Description:Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluatedMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z0379CPubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Antagonistic activity against stimulation of GTP (gamma) 35 S binding by glutamate in membranes from CHO cells expressing human mGluR2More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Rattus norvegicus)
Centro de Investigación Lilly, SA

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Antagonistic activity against metabotropic glutamate receptor 2 (mGluR2) was evaluatedMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataIC50: 990nMAssay Description:Antagonistic activity against metabotropic glutamate receptor 7 (mGluR7) was evaluatedMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataIC50: 1.14E+3nMAssay Description:Concentration required to inhibit metabotropic glutamate receptor 6 activity of rat expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GH9HFKPubMed
TargetMetabotropic glutamate receptor 7(Homo sapiens (Human))
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataIC50: 1.60E+3nMMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 4(Rattus norvegicus (Rat))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataIC50: 2.65E+3nMAssay Description:Concentration required to inhibit metabotropic glutamate receptor 4 activity of rat expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GH9HFKPubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataIC50: 7.80E+3nMAssay Description:Antagonistic activity against metabotropic glutamate receptor 1 (mGluR1) was evaluatedMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataIC50: 8.20E+3nMAssay Description:Antagonistic activity against metabotropic glutamate receptor 5 (mGluR5) was evaluatedMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 1(RAT)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataIC50: 8.99E+3nMAssay Description:Concentration required to inhibit metabotropic glutamate receptor 1 activity of rat expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataIC50: 1.14E+4nMAssay Description:Concentration required to inhibit metabotropic glutamate receptor 5 activity of rat expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataIC50: 2.20E+4nMAssay Description:Antagonistic activity against metabotropic glutamate receptor 4 (mGluR4) was evaluatedMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z0379CPubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataEC50: >1.00E+5nMAssay Description:Effective concentration for agonistic activity towards metabotropic glutamate receptor 2 of rat expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Rattus norvegicus (Rat))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataEC50: >1.00E+5nMAssay Description:Effective concentration for agonistic activity towards metabotropic glutamate receptor 3 of rat expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataEC50: >1.00E+5nMAssay Description:Effective concentration for agonistic activity towards metabotropic glutamate receptor 5 of rat expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 1(RAT)
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataEC50: >1.00E+5nMAssay Description:Effective concentration for agonistic activity towards metabotropic glutamate receptor 1 of rat expressed in CHO cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 6(Rattus norvegicus (Rat))
Taisho Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)copy SMILEScopy InChI
Affinity DataEC50: >1.00E+5nMAssay Description:Effective concentration for agonistic activity towards metabotropic glutamate receptor 6 of rat expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GH9HFKPubMed