Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 3 hits in this display   

TargetNitric oxide synthase, inducible(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098938(6-Fluoro-3-(4-fluoro-phenyl)-3,4-dihydro-isoquinol...)copy SMILEScopy InChI
Affinity DataIC50: 9.00E+3nMAssay Description:Ability to inhibit conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by inducible NOS (i NOS) from human DLD-1 cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K073JZPubMed
TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098938(6-Fluoro-3-(4-fluoro-phenyl)-3,4-dihydro-isoquinol...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by neuronal NOS (n NOS) from rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K073JZPubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
AstraZeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50098938(6-Fluoro-3-(4-fluoro-phenyl)-3,4-dihydro-isoquinol...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Ability to inhibit conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K073JZPubMed