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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
3
hits in this display
Target
Nitric oxide synthase, inducible
(Homo sapiens (Human))
AstraZeneca R&D Charnwood
Curated by
ChEMBL
Ligand
BDBM50098928
(3-(4-Fluoro-phenyl)-3,4-dihydro-isoquinolin-1-ylam...)
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Affinity Data
IC50: 5.50E+3nM
Assay Description:
Ability to inhibit conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by inducible NOS (i NOS) from human DLD-1 cells
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
BindingDB Entry DOI:
10.7270/Q2K073JZ
PubMed
Target
Nitric oxide synthase, brain
(Rattus norvegicus (rat))
AstraZeneca R&D Charnwood
Curated by
ChEMBL
Ligand
BDBM50098928
(3-(4-Fluoro-phenyl)-3,4-dihydro-isoquinolin-1-ylam...)
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copy InChI
Affinity Data
IC50: 9.00E+3nM
Assay Description:
Inhibition of conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by neuronal NOS (n NOS) from rat cerebellum
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
BindingDB Entry DOI:
10.7270/Q2K073JZ
PubMed
Target
Nitric oxide synthase, endothelial
(Homo sapiens (Human))
AstraZeneca R&D Charnwood
Curated by
ChEMBL
Ligand
BDBM50098928
(3-(4-Fluoro-phenyl)-3,4-dihydro-isoquinolin-1-ylam...)
copy SMILES
copy InChI
Affinity Data
IC50: 4.00E+4nM
Assay Description:
Ability to inhibit conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cells
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
BindingDB Entry DOI:
10.7270/Q2K073JZ
PubMed