Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 9 hits in this display   

TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50155390(3-Amino-N-[(R)-1-(4-chloro-benzyl)-2-oxo-2-(4-{2-[...)copy SMILEScopy InChI
Affinity DataKi:  21nMAssay Description:Agonist activity at human MC4 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2610ZSQPubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50155390(3-Amino-N-[(R)-1-(4-chloro-benzyl)-2-oxo-2-(4-{2-[...)copy SMILEScopy InChI
Affinity DataKi:  21nMAssay Description:Tested for inhibition of binding to MC4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB82K8PubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50155390(3-Amino-N-[(R)-1-(4-chloro-benzyl)-2-oxo-2-(4-{2-[...)copy SMILEScopy InChI
Affinity DataKi:  21nMAssay Description:Binding affinity for melanocortin-4 receptor transfected in HEK 293 cells using [125I]-NDP-MSH as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z1527PubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Neurocrine Biosciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50155390(3-Amino-N-[(R)-1-(4-chloro-benzyl)-2-oxo-2-(4-{2-[...)copy SMILEScopy InChI
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity towards human melanocortin 5 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB82K8PubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Neurocrine Biosciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50155390(3-Amino-N-[(R)-1-(4-chloro-benzyl)-2-oxo-2-(4-{2-[...)copy SMILEScopy InChI
Affinity DataKi:  1.00E+3nMAssay Description:Binding affinity towards human melanocortin 3 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB82K8PubMed
TargetMelanocortin receptor 5(Homo sapiens (Human))
Neurocrine Biosciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50155390(3-Amino-N-[(R)-1-(4-chloro-benzyl)-2-oxo-2-(4-{2-[...)copy SMILEScopy InChI
Affinity DataKi:  1.00E+3nMAssay Description:Displacement of [125]NDP-MSH from human MC5 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2610ZSQPubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50155390(3-Amino-N-[(R)-1-(4-chloro-benzyl)-2-oxo-2-(4-{2-[...)copy SMILEScopy InChI
Affinity DataKi:  1.30E+3nMAssay Description:Binding affinity towards human melanocortin 1 receptor expressed in HEK 293 cells was determined by using [125I]NDP-MSH as radioligandMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB82K8PubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50155390(3-Amino-N-[(R)-1-(4-chloro-benzyl)-2-oxo-2-(4-{2-[...)copy SMILEScopy InChI
Affinity DataKi:  1.30E+3nMAssay Description:Displacement of [125]NDP-MSH from human MC1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2610ZSQPubMed
TargetMelanocortin receptor 3(Homo sapiens (Human))
Neurocrine Biosciences, Inc.

Curated by ChEMBL
LigandPNGBDBM50155390(3-Amino-N-[(R)-1-(4-chloro-benzyl)-2-oxo-2-(4-{2-[...)copy SMILEScopy InChI
Affinity DataKi:  1.40E+3nMAssay Description:Displacement of [125]NDP-MSH from human MC3receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2610ZSQPubMed