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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
21
hits in this display
Target
Nitric oxide synthase, brain
(Rattus norvegicus (rat))
Northwestern University
Curated by
ChEMBL
Ligand
BDBM50255304
((S)-1-(4-amino-5-(2-aminoethylamino)pentyl)-3-nitr...)
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Affinity Data
Ki: 100nM
Assay Description:
Inhibition of rat recombinant nNOS expressed in Escherichia coli by hemoglobin capture assay
More data for this Ligand-Target Pair
Target Info
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Article
BindingDB Entry DOI:
10.7270/Q27D2V01
PubMed
Target
Nitric oxide synthase, brain
(Rattus norvegicus (rat))
Northwestern University
Curated by
ChEMBL
Ligand
BDBM21960
(3-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-1-n...)
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Affinity Data
Ki: 120nM
Assay Description:
Inhibitory activity against Neuronal Nitric Oxide Synthase (nNOS)
More data for this Ligand-Target Pair
Target Info
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Article
BindingDB Entry DOI:
10.7270/Q23J3DQK
PubMed
MMDB
PDB
3D Structure (crystal)
Target
Nitric oxide synthase, brain
(Rattus norvegicus (rat))
Northwestern University
Curated by
ChEMBL
Ligand
BDBM21960
(3-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-1-n...)
copy SMILES
copy InChI
Affinity Data
Ki: 120nM
Assay Description:
Inhibitory activity against recombinant rat nNOS.
More data for this Ligand-Target Pair
Target Info
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BindingDB Entry DOI:
10.7270/Q29K4BX1
PubMed
MMDB
PDB
3D Structure (crystal)
Target
Nitric oxide synthase, brain
(Rattus norvegicus (rat))
Northwestern University
Curated by
ChEMBL
Ligand
BDBM21960
(3-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-1-n...)
copy SMILES
copy InChI
Affinity Data
Ki: 150nM ΔG°: -39.6kJ/mole
pH: 7.5 T: 2°C
Assay Description:
Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...
More data for this Ligand-Target Pair
Target Info
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Article
BindingDB Entry DOI:
10.7270/Q2HX1B1J
PubMed
MMDB
PDB
3D Structure (crystal)
Target
Nitric oxide synthase, brain
(Rattus norvegicus (rat))
Northwestern University
Curated by
ChEMBL
Ligand
BDBM21960
(3-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-1-n...)
copy SMILES
copy InChI
Affinity Data
Ki: 150nM ΔG°: -39.6kJ/mole
pH: 7.5 T: 2°C
Assay Description:
Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
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Ligand Info
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Article
BindingDB Entry DOI:
10.7270/Q27942ZS
PubMed
MMDB
PDB
3D Structure (crystal)
Target
Nitric oxide synthase, brain
(Rattus norvegicus (rat))
Northwestern University
Curated by
ChEMBL
Ligand
BDBM21960
(3-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-1-n...)
copy SMILES
copy InChI
Affinity Data
Ki: 170nM ΔG°: -39.3kJ/mole
pH: 7.5 T: 2°C
Assay Description:
Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...
More data for this Ligand-Target Pair
Target Info
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In Depth
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Article
BindingDB Entry DOI:
10.7270/Q2W0947W
PubMed
MMDB
PDB
3D Structure (crystal)
Target
Nitric oxide synthase, brain
(Homo sapiens (Human))
Northwestern University
Curated by
ChEMBL
Ligand
BDBM21960
(3-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-1-n...)
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copy InChI
Affinity Data
Ki: 290nM
Assay Description:
Inhibitory activity against neuronal nitric oxide synthase
Checked by Author
More data for this Ligand-Target Pair
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Article
BindingDB Entry DOI:
10.7270/Q26D5TQV
PubMed
PDB
3D Structure (crystal)
Target
Nitric oxide synthase, endothelial [N368D]
(Bos taurus (bovine))
University of California at Irvine
Ligand
BDBM21960
(3-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-1-n...)
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Affinity Data
Ki: 4.60E+3nM ΔG°: -31.0kJ/mole
pH: 7.5 T: 2°C
Assay Description:
Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...
More data for this Ligand-Target Pair
Target Info
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In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q27942ZS
PubMed
PDB
3D Structure (crystal)
Target
Nitric oxide synthase, inducible
(Mus musculus (mouse))
Northwestern University
Ligand
BDBM21960
(3-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-1-n...)
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Affinity Data
Ki: 1.80E+4nM ΔG°: -27.5kJ/mole
pH: 7.5 T: 2°C
Assay Description:
Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...
More data for this Ligand-Target Pair
Target Info
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MMDB
Reactome pathway
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In Depth
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Article
BindingDB Entry DOI:
10.7270/Q2W0947W
PubMed
Target
Nitric oxide synthase, brain [D597N]
(Rattus norvegicus (rat))
University of California at Irvine
Ligand
BDBM21960
(3-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-1-n...)
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copy InChI
Affinity Data
Ki: 3.40E+4nM ΔG°: -25.9kJ/mole
pH: 7.5 T: 2°C
Assay Description:
Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
CHEMBL
MMDB
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PC sid
PDB
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In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q27942ZS
PubMed
MMDB
PDB
3D Structure (crystal)
Target
Nitric oxide synthase, inducible
(Mus musculus (mouse))
Northwestern University
Ligand
BDBM21960
(3-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-1-n...)
copy SMILES
copy InChI
Affinity Data
Ki: 3.90E+4nM
Assay Description:
Inhibitory activity against Inducible nitric oxide synthase (iNOS)
More data for this Ligand-Target Pair
Target Info
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MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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Ligand Info
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CHEMBL
MMDB
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In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q23J3DQK
PubMed
Target
Nitric oxide synthase, inducible
(Mus musculus (mouse))
Northwestern University
Ligand
BDBM50255304
((S)-1-(4-amino-5-(2-aminoethylamino)pentyl)-3-nitr...)
copy SMILES
copy InChI
Affinity Data
Ki: 3.90E+4nM
Assay Description:
Inhibition of mouse recombinant iNOS expressed in Escherichia coli by hemoglobin capture assay
More data for this Ligand-Target Pair
Target Info
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Reactome pathway
KEGG
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CHEMBL
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In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q27D2V01
PubMed
Target
Nitric oxide synthase, inducible
(Mus musculus (mouse))
Northwestern University
Ligand
BDBM21960
(3-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-1-n...)
copy SMILES
copy InChI
Affinity Data
Ki: 3.90E+4nM
Assay Description:
Inhibitory activity against recombinant murine iNOS.
More data for this Ligand-Target Pair
Target Info
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Reactome pathway
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In Depth
Details
BindingDB Entry DOI:
10.7270/Q29K4BX1
PubMed
Target
Nitric oxide synthase, inducible
(Mus musculus (mouse))
Northwestern University
Curated by
ChEMBL
Ligand
BDBM21960
(3-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-1-n...)
copy SMILES
copy InChI
Affinity Data
Ki: 7.30E+4nM
Assay Description:
Inhibitory activity against Inducible nitric oxide synthase
Checked by Author
More data for this Ligand-Target Pair
Target Info
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CHEMBL
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In Depth
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Article
BindingDB Entry DOI:
10.7270/Q26D5TQV
PubMed
Target
Nitric oxide synthase, endothelial
(Bos taurus (bovine))
University of California at Irvine
Ligand
BDBM21960
(3-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-1-n...)
copy SMILES
copy InChI
Affinity Data
Ki: 8.00E+4nM ΔG°: -23.8kJ/mole
pH: 7.5 T: 2°C
Assay Description:
Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
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GoogleScholar
Ligand Info
Purchase
CHEMBL
MMDB
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PC sid
PDB
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In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2HX1B1J
PubMed
PDB
3D Structure (crystal)
Target
Nitric oxide synthase, endothelial
(Bos taurus (bovine))
University of California at Irvine
Ligand
BDBM21960
(3-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-1-n...)
copy SMILES
copy InChI
Affinity Data
Ki: 8.00E+4nM ΔG°: -23.8kJ/mole
pH: 7.5 T: 2°C
Assay Description:
Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
Purchase
CHEMBL
MMDB
PC cid
PC sid
PDB
Patents
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In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q27942ZS
PubMed
PDB
3D Structure (crystal)
Target
Nitric oxide synthase, endothelial
(Bos taurus (bovine))
University of California at Irvine
Ligand
BDBM21960
(3-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-1-n...)
copy SMILES
copy InChI
Affinity Data
Ki: 1.91E+5nM ΔG°: -21.6kJ/mole
pH: 7.5 T: 2°C
Assay Description:
Nitric oxide formation from NOS was monitored by the hemoglobin capture assay. The assay was initiated by addition of enzyme and was monitored at 401...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
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GoogleScholar
Ligand Info
Purchase
CHEMBL
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PDB
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In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2W0947W
PubMed
PDB
3D Structure (crystal)
Target
Nitric oxide synthase, endothelial
(Bos taurus (bovine))
University of California at Irvine
Ligand
BDBM21960
(3-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-1-n...)
copy SMILES
copy InChI
Affinity Data
Ki: 3.14E+5nM
Assay Description:
Inhibitory activity against recombinant bovine eNOS.
More data for this Ligand-Target Pair
Target Info
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In Depth
Details
BindingDB Entry DOI:
10.7270/Q29K4BX1
PubMed
PDB
3D Structure (crystal)
Target
Nitric oxide synthase, endothelial
(Bos taurus (bovine))
University of California at Irvine
Ligand
BDBM50255304
((S)-1-(4-amino-5-(2-aminoethylamino)pentyl)-3-nitr...)
copy SMILES
copy InChI
Affinity Data
Ki: 3.14E+5nM
Assay Description:
Inhibition of bovine recombinant eNOS expressed in Escherichia coli by hemoglobin capture assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
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GoogleScholar
Ligand Info
CHEMBL
PC cid
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Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q27D2V01
PubMed
Target
Nitric oxide synthase, endothelial
(Bos taurus (bovine))
University of California at Irvine
Ligand
BDBM21960
(3-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-1-n...)
copy SMILES
copy InChI
Affinity Data
Ki: 3.14E+5nM
Assay Description:
Inhibitory activity against endothelial nitric oxide synthase (eNOS)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
Purchase
CHEMBL
MMDB
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PC sid
PDB
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In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q23J3DQK
PubMed
PDB
3D Structure (crystal)
Target
Nitric oxide synthase, endothelial
(Homo sapiens (Human))
Northwestern University
Curated by
ChEMBL
Ligand
BDBM21960
(3-[(4S)-4-amino-5-[(2-aminoethyl)amino]pentyl]-1-n...)
copy SMILES
copy InChI
Affinity Data
Ki: 5.24E+5nM
Assay Description:
Inhibitory activity against endothelial nitric oxide synthase (eNOS)
Checked by Author
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MMDB
PC cid
PC sid
PDB
Patents
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In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q26D5TQV
PubMed
PDB
3D Structure (crystal)