Home
About
Info
Download
WebServices
Contact
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
21
hits in this display
Target
Amiloride-sensitive amine oxidase [copper-containing]
(Homo sapiens (Human))
TBA
Curated by
ChEMBL
Ligand
BDBM50207159
(2-aminoguanidine | 2-azanylguanidine | AMINOGUANID...)
copy SMILES
copy InChI
Affinity Data
Ki: 140nM
Assay Description:
Tested for ability of the compound to competitively inhibit hog kidney diamine oxidase (DAO) in a spectrometric assay
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q24749ST
Target
Nitric oxide synthase, brain
(Homo sapiens (Human))
Instituto de Química Médica
Curated by
ChEMBL
Ligand
BDBM50207159
(2-aminoguanidine | 2-azanylguanidine | AMINOGUANID...)
copy SMILES
copy InChI
Affinity Data
Ki: 3.30E+3nM
Assay Description:
Inhibition of nNOS (unknown origin) assessed as conversion of L-[3H]arginine to L-[3H]citrulline
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2611040
PubMed
Target
Nitric oxide synthase, inducible
(Homo sapiens (Human))
AstraZeneca R& D Charnwood
Curated by
ChEMBL
Ligand
BDBM50207159
(2-aminoguanidine | 2-azanylguanidine | AMINOGUANID...)
copy SMILES
copy InChI
Affinity Data
IC50: 3.90E+3nM
Assay Description:
Inhibitory activity of compound against human inducible nitiric oxide synthase
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2S75H3M
PubMed
MMDB
PDB
3D Structure (crystal)
Target
Nitric oxide synthase, inducible
(Homo sapiens (Human))
AstraZeneca R& D Charnwood
Curated by
ChEMBL
Ligand
BDBM50207159
(2-aminoguanidine | 2-azanylguanidine | AMINOGUANID...)
copy SMILES
copy InChI
Affinity Data
IC50: 4.50E+3nM
Assay Description:
Ability to inhibit conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by inducible NOS (i NOS) from human DLD-1 cells
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
BindingDB Entry DOI:
10.7270/Q2K073JZ
PubMed
MMDB
PDB
3D Structure (crystal)
Target
Nitric oxide synthase, brain
(Homo sapiens (Human))
Instituto de Química Médica
Curated by
ChEMBL
Ligand
BDBM50207159
(2-aminoguanidine | 2-azanylguanidine | AMINOGUANID...)
copy SMILES
copy InChI
Affinity Data
IC50: 5.90E+3nM
Assay Description:
Inhibitory activity against human neuronal nitiric oxide synthase
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2S75H3M
PubMed
Target
Nitric oxide synthase, brain
(Rattus norvegicus (rat))
AstraZeneca R&D Charnwood
Curated by
ChEMBL
Ligand
BDBM50207159
(2-aminoguanidine | 2-azanylguanidine | AMINOGUANID...)
copy SMILES
copy InChI
Affinity Data
IC50: 6.00E+3nM
Assay Description:
Inhibition of conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by neuronal NOS (n NOS) from rat cerebellum
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
BindingDB Entry DOI:
10.7270/Q2K073JZ
PubMed
Target
Nitric oxide synthase, inducible
(Mus musculus (mouse))
TBA
Curated by
ChEMBL
Ligand
BDBM50207159
(2-aminoguanidine | 2-azanylguanidine | AMINOGUANID...)
copy SMILES
copy InChI
Affinity Data
IC50: 9.00E+3nM
Assay Description:
Tested to inhibit the conversion of [3H]-L-arginine to [3H]-L-citrulline catalyzed by inducible NOS from mouse macrophage J774 cells
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q25T3KD0
DrugBank
MMDB
PDB
3D Structure (crystal)
Target
Nitric oxide synthase, brain
(Rattus norvegicus (rat))
AstraZeneca R&D Charnwood
Curated by
ChEMBL
Ligand
BDBM50207159
(2-aminoguanidine | 2-azanylguanidine | AMINOGUANID...)
copy SMILES
copy InChI
Affinity Data
IC50: 1.94E+4nM
Assay Description:
Inhibition of nNOS in Sprague-Dawley rat brain homogenates assessed as conversion of oxyhemoglobin to methemoglobin measured for 10 mins by UV-visibl...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2H132CH
PubMed
Target
Nitric oxide synthase, inducible
(Mus musculus (mouse))
TBA
Curated by
ChEMBL
Ligand
BDBM50207159
(2-aminoguanidine | 2-azanylguanidine | AMINOGUANID...)
copy SMILES
copy InChI
Affinity Data
IC50: 2.66E+4nM
Assay Description:
Inhibition of iNOS in mouse RAW264.7 cells assessed as anti-inflammatory activity by measuring maximum inhibition of LPS-induced nitric oxide product...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2474B72
PubMed
DrugBank
MMDB
PDB
3D Structure (crystal)
Target
Nitric oxide synthase, inducible
(Mus musculus (mouse))
TBA
Curated by
ChEMBL
Ligand
BDBM50207159
(2-aminoguanidine | 2-azanylguanidine | AMINOGUANID...)
copy SMILES
copy InChI
Affinity Data
IC50: 2.85E+4nM
Assay Description:
Inhibition of iNOS-mediated NO production in LPS-stimulated mouse RAW264.7 cells after 24 hrs by Griess reagent method
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2ST7Q8Z
PubMed
DrugBank
MMDB
PDB
3D Structure (crystal)
Target
Aldo-keto reductase family 1 member B1
(Rattus norvegicus)
Korean Institute of Oriental Medicine (KIOM)
Curated by
ChEMBL
Ligand
BDBM50207159
(2-aminoguanidine | 2-azanylguanidine | AMINOGUANID...)
copy SMILES
copy InChI
Affinity Data
IC50: 3.00E+4nM
Assay Description:
Inhibition of Sprague-Dawley rat lens aldose reductase
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2XS5WCH
PubMed
Target
Nitric oxide synthase, inducible
(Homo sapiens (Human))
AstraZeneca R& D Charnwood
Curated by
ChEMBL
Ligand
BDBM50207159
(2-aminoguanidine | 2-azanylguanidine | AMINOGUANID...)
copy SMILES
copy InChI
Affinity Data
IC50: 5.40E+4nM
Assay Description:
Tested to inhibit the conversion of [3H]-L-arginine to [3H]-L-citrulline catalyzed by inducible NOS from human DLD-1 cells.
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q25T3KD0
MMDB
PDB
3D Structure (crystal)
Target
Nitric oxide synthase, endothelial
(Homo sapiens (Human))
AstraZeneca R&D Charnwood
Curated by
ChEMBL
Ligand
BDBM50207159
(2-aminoguanidine | 2-azanylguanidine | AMINOGUANID...)
copy SMILES
copy InChI
Affinity Data
IC50: 7.20E+4nM
Assay Description:
Ability to inhibit conversion of [3H]-L-Arg to [3H]-L-citrulline catalyzed by endothelial NOS (e NOS) from HUVEC cells
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
BindingDB Entry DOI:
10.7270/Q2K073JZ
PubMed
Target
Nitric oxide synthase, endothelial
(Homo sapiens (Human))
AstraZeneca R&D Charnwood
Curated by
ChEMBL
Ligand
BDBM50207159
(2-aminoguanidine | 2-azanylguanidine | AMINOGUANID...)
copy SMILES
copy InChI
Affinity Data
IC50: 1.00E+5nM
Assay Description:
Inhibitory activity against human endothelial nitiric oxide synthase
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2S75H3M
PubMed
Target
Nitric oxide synthase, inducible
(Homo sapiens (Human))
AstraZeneca R& D Charnwood
Curated by
ChEMBL
Ligand
BDBM50207159
(2-aminoguanidine | 2-azanylguanidine | AMINOGUANID...)
copy SMILES
copy InChI
Affinity Data
IC50: 1.01E+5nM
Assay Description:
Inhibitory activity against inducible nitric oxide synthase (iNOS)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
BindingDB Entry DOI:
10.7270/Q2319V30
PubMed
MMDB
PDB
3D Structure (crystal)
Target
Nitric oxide synthase, brain
(Homo sapiens (Human))
Instituto de Química Médica
Curated by
ChEMBL
Ligand
BDBM50207159
(2-aminoguanidine | 2-azanylguanidine | AMINOGUANID...)
copy SMILES
copy InChI
Affinity Data
IC50: 1.18E+5nM
Assay Description:
Inhibitory activity against neuronal nitric oxide synthase
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
BindingDB Entry DOI:
10.7270/Q2319V30
PubMed
Target
Nitric oxide synthase, inducible
(Rattus norvegicus)
Ernst Moritz Arndt University Greifswald
Curated by
ChEMBL
Ligand
BDBM50207159
(2-aminoguanidine | 2-azanylguanidine | AMINOGUANID...)
copy SMILES
copy InChI
Affinity Data
IC50: 1.32E+5nM
Assay Description:
Inhibition of iNOS-mediated NO production in IL-1beta/IFNgamma-stimulated rat RINmF cells by Griess reaction
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2CN759B
PubMed
MMDB
PDB
3D Structure (crystal)
Target
Nitric oxide synthase, endothelial
(Homo sapiens (Human))
AstraZeneca R&D Charnwood
Curated by
ChEMBL
Ligand
BDBM50207159
(2-aminoguanidine | 2-azanylguanidine | AMINOGUANID...)
copy SMILES
copy InChI
Affinity Data
IC50: 5.00E+5nM
Assay Description:
Inhibitory activity against endothelial nitric oxide synthase (eNOS)
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
BindingDB Entry DOI:
10.7270/Q2319V30
PubMed
Target
Catalase
(Bos taurus)
University of California
Curated by
ChEMBL
Ligand
BDBM50207159
(2-aminoguanidine | 2-azanylguanidine | AMINOGUANID...)
copy SMILES
copy InChI
Affinity Data
IC50: 5.00E+5nM
Assay Description:
Inhibition of Bos taurus (bovine) CAT in liver
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2QF8WR8
PubMed
Target
Nitric oxide synthase, inducible
(Homo sapiens (Human))
AstraZeneca R& D Charnwood
Curated by
ChEMBL
Ligand
BDBM50207159
(2-aminoguanidine | 2-azanylguanidine | AMINOGUANID...)
copy SMILES
copy InChI
Affinity Data
IC50: 1.10E+9nM
Assay Description:
Inhibitory concentration against nitric oxide synthesis in intact DLD-1 cells
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
BindingDB Entry DOI:
10.7270/Q2K073JZ
PubMed
MMDB
PDB
3D Structure (crystal)
Target
Albumin
(Bos taurus)
Unidad de Gen�mica Avanzada (Langebio)
Curated by
ChEMBL
Ligand
BDBM50207159
(2-aminoguanidine | 2-azanylguanidine | AMINOGUANID...)
copy SMILES
copy InChI
Affinity Data
EC50: 2.60E+7nM
Assay Description:
Antiglycation activity in bovine serum albumin assessed as inhibition of advanced glycated end product formation in presence of D-glucose by spectrof...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
Patents
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2PC350T
PubMed