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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
6
hits in this display
Target
Nitric oxide synthase, brain
(Rattus norvegicus (rat))
Northwestern University
US Patent
Ligand
BDBM50449047
(CHEMBL3126214 | US9212144, 6 (Ex. 12))
copy SMILES
copy InChI
Affinity Data
Ki: 254nM
pH: 7.4
Assay Description:
To test for enzyme inhibition, the hemoglobin capture assay was used to measure nitric oxide production. The assay was performed at 37° C. in HEPES b...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
BindingDB Entry DOI:
10.7270/Q2K0732P
US Patent
PDB
3D Structure (crystal)
Target
Nitric oxide synthase, brain
(Rattus norvegicus (rat))
Northwestern University
US Patent
Ligand
BDBM50449047
(CHEMBL3126214 | US9212144, 6 (Ex. 12))
copy SMILES
copy InChI
Affinity Data
Ki: 254nM
Assay Description:
Inhibition of rat recombinant nNOS expressed in Escherichia coli using L-arginine as substrate assessed as NO production by hemoglobin capture assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2MP54SZ
PubMed
PDB
3D Structure (crystal)
Target
Nitric oxide synthase, endothelial
(Bos taurus (bovine))
Northwestern University
Curated by
ChEMBL
Ligand
BDBM50449047
(CHEMBL3126214 | US9212144, 6 (Ex. 12))
copy SMILES
copy InChI
Affinity Data
Ki: 7.77E+3nM
Assay Description:
Inhibition of bovine recombinant eNOS expressed in Escherichia coli using L-arginine as substrate assessed as NO production by hemoglobin capture ass...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2MP54SZ
PubMed
Target
Nitric oxide synthase, endothelial
(Bos taurus (bovine))
Northwestern University
Curated by
ChEMBL
Ligand
BDBM50449047
(CHEMBL3126214 | US9212144, 6 (Ex. 12))
copy SMILES
copy InChI
Affinity Data
Ki: 7.77E+3nM
pH: 7.4
Assay Description:
To test for enzyme inhibition, the hemoglobin capture assay was used to measure nitric oxide production. The assay was performed at 37° C. in HEPES b...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
BindingDB Entry DOI:
10.7270/Q2K0732P
US Patent
Target
Nitric oxide synthase, inducible
(Mus musculus (mouse))
Northwestern University
Curated by
ChEMBL
Ligand
BDBM50449047
(CHEMBL3126214 | US9212144, 6 (Ex. 12))
copy SMILES
copy InChI
Affinity Data
Ki: 2.45E+4nM
Assay Description:
Inhibition of mouse recombinant iNOS expressed in Escherichia coli using L-arginine as substrate assessed as NO production by hemoglobin capture assa...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2MP54SZ
PubMed
Target
Nitric oxide synthase, inducible
(Mus musculus (mouse))
Northwestern University
Curated by
ChEMBL
Ligand
BDBM50449047
(CHEMBL3126214 | US9212144, 6 (Ex. 12))
copy SMILES
copy InChI
Affinity Data
Ki: 2.45E+4nM
pH: 7.4
Assay Description:
To test for enzyme inhibition, the hemoglobin capture assay was used to measure nitric oxide production. The assay was performed at 37° C. in HEPES b...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
PDB
Similars
In Depth
Details
BindingDB Entry DOI:
10.7270/Q2K0732P
US Patent