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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
12
hits in this display
Target
Urokinase-type plasminogen activator
(Homo sapiens (Human))
Abbott Laboratories
Curated by
ChEMBL
Ligand
BDBM14320
(1-amino-isoquinoline | CHEMBL62083 | Fragment 17 |...)
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Affinity Data
Ki: 5.01E+4nM
Assay Description:
Inhibition of urokinase
More data for this Ligand-Target Pair
Target Info
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Article
BindingDB Entry DOI:
10.7270/Q2FF3TM8
PubMed
Target
Tryptase beta-2
(Homo sapiens (Human))
Celera
Ligand
BDBM14320
(1-amino-isoquinoline | CHEMBL62083 | Fragment 17 |...)
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Affinity Data
Ki: 3.90E+5nM
Assay Description:
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...
More data for this Ligand-Target Pair
Target Info
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Article
BindingDB Entry DOI:
10.7270/Q2W09450
PubMed
Target
Neutrophil cytosol factor 1
(Homo sapiens)
University of Copenhagen
Curated by
ChEMBL
Ligand
BDBM14320
(1-amino-isoquinoline | CHEMBL62083 | Fragment 17 |...)
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Affinity Data
Ki: 5.94E+5nM
Assay Description:
Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...
More data for this Ligand-Target Pair
Target Info
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MMDB
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Article
BindingDB Entry DOI:
10.7270/Q2TQ64XB
PubMed
Target
Serine protease 1
(Bos taurus (bovine))
Celera
Ligand
BDBM14320
(1-amino-isoquinoline | CHEMBL62083 | Fragment 17 |...)
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Affinity Data
Ki: 6.00E+5nM
Assay Description:
Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...
More data for this Ligand-Target Pair
Target Info
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BindingDB Entry DOI:
10.7270/Q2W09450
PubMed
Target
Coagulation factor VII/Tissue factor
(Homo sapiens (Human))
Bristol-Myers Squibb R&D
Curated by
ChEMBL
Ligand
BDBM14320
(1-amino-isoquinoline | CHEMBL62083 | Fragment 17 |...)
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Affinity Data
Ki: 4.00E+6nM
Assay Description:
Inhibition of recombinant human factor-7a/TF using S2288 as substrate measured after 60 mins
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Article
BindingDB Entry DOI:
10.7270/Q2GB2613
PubMed
Target
Nitric oxide synthase, endothelial
(Homo sapiens (Human))
Merck Research Laboratories Rahway
Curated by
ChEMBL
Ligand
BDBM14320
(1-amino-isoquinoline | CHEMBL62083 | Fragment 17 |...)
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Affinity Data
IC50: 1.40E+3nM
Assay Description:
Inhibitory activity against endothelial nitric oxide synthase (eNOS)
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BindingDB Entry DOI:
10.7270/Q2319V30
PubMed
Target
Nitric oxide synthase, inducible
(Homo sapiens (Human))
Merck Research Laboratories Rahway
Curated by
ChEMBL
Ligand
BDBM14320
(1-amino-isoquinoline | CHEMBL62083 | Fragment 17 |...)
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Affinity Data
IC50: 4.60E+3nM
Assay Description:
Inhibitory activity against inducible nitric oxide synthase (iNOS)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
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BindingDB Entry DOI:
10.7270/Q2319V30
PubMed
Target
Nitric oxide synthase, brain
(Homo sapiens (Human))
Merck Research Laboratories Rahway
Curated by
ChEMBL
Ligand
BDBM14320
(1-amino-isoquinoline | CHEMBL62083 | Fragment 17 |...)
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Affinity Data
IC50: 6.60E+3nM
Assay Description:
Inhibitory activity against neuronal nitric oxide synthase
More data for this Ligand-Target Pair
Target Info
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BindingDB Entry DOI:
10.7270/Q2319V30
PubMed
Target
Beta-secretase 1
(Homo sapiens (Human))
Astex Therapeutics Ltd.
Curated by
ChEMBL
Ligand
BDBM14320
(1-amino-isoquinoline | CHEMBL62083 | Fragment 17 |...)
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Affinity Data
IC50: 2.00E+6nM
Assay Description:
Inhibition of BACE1
More data for this Ligand-Target Pair
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Article
BindingDB Entry DOI:
10.7270/Q2N58M4H
PubMed
MMDB
PDB
3D Structure (crystal)
Target
Tyrosine-protein kinase
(Mus musculus)
The University of Adelaide
Curated by
ChEMBL
Ligand
BDBM14320
(1-amino-isoquinoline | CHEMBL62083 | Fragment 17 |...)
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Affinity Data
Kd: 6.50E+5nM
Assay Description:
Displacement of PRP-1 peptide from mouse Tec kinase SH3 domain by fluorescence polarization
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Article
BindingDB Entry DOI:
10.7270/Q26M369B
PubMed
Target
Beta-secretase 1
(Homo sapiens (Human))
Astex Therapeutics Ltd.
Curated by
ChEMBL
Ligand
BDBM14320
(1-amino-isoquinoline | CHEMBL62083 | Fragment 17 |...)
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Affinity Data
pH: 5.0 T: 2°C
Assay Description:
Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...
More data for this Ligand-Target Pair
Target Info
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Article
BindingDB Entry DOI:
10.7270/Q2Q23XHV
PubMed
MMDB
PDB
3D Structure (crystal)
Target
Neutrophil cytosol factor 1
(Homo sapiens)
University of Copenhagen
Curated by
ChEMBL
Ligand
BDBM14320
(1-amino-isoquinoline | CHEMBL62083 | Fragment 17 |...)
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Affinity Data
Kd: 6.87E+5nM
Assay Description:
Binding affinity to immobilized recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cel...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q2TQ64XB
PubMed