Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 12 hits in this display   

TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM14320(1-amino-isoquinoline | CHEMBL62083 | Fragment 17 |...)copy SMILEScopy InChI
Affinity DataKi:  5.01E+4nMAssay Description:Inhibition of urokinaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3TM8PubMed
TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM14320(1-amino-isoquinoline | CHEMBL62083 | Fragment 17 |...)copy SMILEScopy InChI
Affinity DataKi:  3.90E+5nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W09450PubMed
TargetNeutrophil cytosol factor 1(Homo sapiens)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM14320(1-amino-isoquinoline | CHEMBL62083 | Fragment 17 |...)copy SMILEScopy InChI
Affinity DataKi:  5.94E+5nMAssay Description:Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TQ64XBPubMed
TargetSerine protease 1(Bos taurus (bovine))
Celera

LigandPNGBDBM14320(1-amino-isoquinoline | CHEMBL62083 | Fragment 17 |...)copy SMILEScopy InChI
Affinity DataKi:  6.00E+5nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W09450PubMed
TargetCoagulation factor VII/Tissue factor(Homo sapiens (Human))
Bristol-Myers Squibb R&D

Curated by ChEMBL
LigandPNGBDBM14320(1-amino-isoquinoline | CHEMBL62083 | Fragment 17 |...)copy SMILEScopy InChI
Affinity DataKi:  4.00E+6nMAssay Description:Inhibition of recombinant human factor-7a/TF using S2288 as substrate measured after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB2613PubMed
TargetNitric oxide synthase, endothelial(Homo sapiens (Human))
Merck Research Laboratories Rahway

Curated by ChEMBL
LigandPNGBDBM14320(1-amino-isoquinoline | CHEMBL62083 | Fragment 17 |...)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibitory activity against endothelial nitric oxide synthase (eNOS)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2319V30PubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Merck Research Laboratories Rahway

Curated by ChEMBL
LigandPNGBDBM14320(1-amino-isoquinoline | CHEMBL62083 | Fragment 17 |...)copy SMILEScopy InChI
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibitory activity against inducible nitric oxide synthase (iNOS)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2319V30PubMed
TargetNitric oxide synthase, brain(Homo sapiens (Human))
Merck Research Laboratories Rahway

Curated by ChEMBL
LigandPNGBDBM14320(1-amino-isoquinoline | CHEMBL62083 | Fragment 17 |...)copy SMILEScopy InChI
Affinity DataIC50: 6.60E+3nMAssay Description:Inhibitory activity against neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2319V30PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astex Therapeutics Ltd.

Curated by ChEMBL
LigandPNGBDBM14320(1-amino-isoquinoline | CHEMBL62083 | Fragment 17 |...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+6nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
TargetTyrosine-protein kinase(Mus musculus)
The University of Adelaide

Curated by ChEMBL
LigandPNGBDBM14320(1-amino-isoquinoline | CHEMBL62083 | Fragment 17 |...)copy SMILEScopy InChI
Affinity DataKd:  6.50E+5nMAssay Description:Displacement of PRP-1 peptide from mouse Tec kinase SH3 domain by fluorescence polarizationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M369BPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Astex Therapeutics Ltd.

Curated by ChEMBL
LigandPNGBDBM14320(1-amino-isoquinoline | CHEMBL62083 | Fragment 17 |...)copy SMILEScopy InChI
Affinity DatapH: 5.0 T: 2°CAssay Description:Activity of BACE-1 was measured by monitoring the cleavage of its peptide substrate on a Fluoroskan Ascent plate reader with excitation and emission ...More data for this Ligand-Target Pair
TargetNeutrophil cytosol factor 1(Homo sapiens)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM14320(1-amino-isoquinoline | CHEMBL62083 | Fragment 17 |...)copy SMILEScopy InChI
Affinity DataKd:  6.87E+5nMAssay Description:Binding affinity to immobilized recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TQ64XBPubMed