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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
13
hits in this display
Target
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human))
Merck Frosst Canada Ltd
Curated by
ChEMBL
Ligand
BDBM50319837
(4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...)
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Affinity Data
Ki: 0.230nM
Assay Description:
Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting
More data for this Ligand-Target Pair
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Article
BindingDB Entry DOI:
10.7270/Q20P106K
PubMed
Target
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human))
Merck Frosst Canada Ltd
Curated by
ChEMBL
Ligand
BDBM50319837
(4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...)
copy SMILES
copy InChI
Affinity Data
Ki: 0.340nM
Assay Description:
Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting in presence of 10%...
More data for this Ligand-Target Pair
Target Info
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KEGG
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antibodypedia
GoogleScholar
Ligand Info
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In Depth
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Article
BindingDB Entry DOI:
10.7270/Q20P106K
PubMed
Target
Prostaglandin D2 receptor
(Homo sapiens (Human))
Merck Frosst Canada Ltd
Curated by
ChEMBL
Ligand
BDBM50319837
(4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...)
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Affinity Data
Ki: 1.65E+3nM
Assay Description:
Displacement of [3H]PGD2 from human Prostanoid DP1 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting
More data for this Ligand-Target Pair
Target Info
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Article
BindingDB Entry DOI:
10.7270/Q20P106K
PubMed
Target
Prostaglandin F2-alpha receptor
(Homo sapiens (Human))
Merck Frosst Canada Ltd
Curated by
ChEMBL
Ligand
BDBM50319837
(4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...)
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Affinity Data
Ki: 6.40E+3nM
Assay Description:
Displacement of [3H]PGF2alpha from human prostanoid FP receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting
More data for this Ligand-Target Pair
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Article
BindingDB Entry DOI:
10.7270/Q20P106K
PubMed
Target
Thromboxane A2 receptor
(Homo sapiens (Human))
Merck Frosst Canada Ltd
Curated by
ChEMBL
Ligand
BDBM50319837
(4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...)
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Affinity Data
Ki: 6.70E+3nM
Assay Description:
Displacement of [3H]SQ-29548 from human prostanoid TP receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting
More data for this Ligand-Target Pair
Target Info
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Article
BindingDB Entry DOI:
10.7270/Q20P106K
PubMed
Target
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human))
Merck Frosst Canada Ltd
Curated by
ChEMBL
Ligand
BDBM50319837
(4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...)
copy SMILES
copy InChI
Affinity Data
Ki: 7.40E+3nM
Assay Description:
Displacement of [3H]PGE2 from human prostanoid EP3 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting
More data for this Ligand-Target Pair
Target Info
PDB
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
MCE
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In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q20P106K
PubMed
Target
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human))
Merck Frosst Canada Ltd
Curated by
ChEMBL
Ligand
BDBM50319837
(4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...)
copy SMILES
copy InChI
Affinity Data
Ki: 8.00E+3nM
Assay Description:
Displacement of [3H]PGE2 from human prostanoid EP2 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
MCE
PC cid
PC sid
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In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q20P106K
PubMed
Target
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human))
Merck Frosst Canada Ltd
Curated by
ChEMBL
Ligand
BDBM50319837
(4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...)
copy SMILES
copy InChI
Affinity Data
Ki: 2.00E+4nM
Assay Description:
Displacement of [3H]PGE2 from human prostanoid EP1 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting
More data for this Ligand-Target Pair
Target Info
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
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In Depth
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Article
BindingDB Entry DOI:
10.7270/Q20P106K
PubMed
Target
Prostaglandin D2 receptor 2
(Homo sapiens (Human))
Merck Frosst Canada Ltd
Curated by
ChEMBL
Ligand
BDBM50319837
(4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...)
copy SMILES
copy InChI
Affinity Data
Ki: >2.10E+4nM
Assay Description:
Displacement of [3H]PGD2 from human Prostanoid DP2 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
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In Depth
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Article
BindingDB Entry DOI:
10.7270/Q20P106K
PubMed
Target
Prostacyclin receptor
(Homo sapiens (Human))
Merck Frosst Canada Ltd
Curated by
ChEMBL
Ligand
BDBM50319837
(4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...)
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Affinity Data
Ki: >2.10E+4nM
Assay Description:
Displacement of [3H]iloprost from human prostanoid IP receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
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CHEMBL
MCE
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In Depth
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Article
BindingDB Entry DOI:
10.7270/Q20P106K
PubMed
Target
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human))
Merck Frosst Canada Ltd
Curated by
ChEMBL
Ligand
BDBM50319837
(4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...)
copy SMILES
copy InChI
Affinity Data
IC50: 1.30nM
Assay Description:
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillat...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q20P106K
PubMed
Target
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human))
Merck Frosst Canada Ltd
Curated by
ChEMBL
Ligand
BDBM50319837
(4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...)
copy SMILES
copy InChI
Affinity Data
IC50: 1.80nM
Assay Description:
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillat...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q20P106K
PubMed
Target
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human))
Merck Frosst Canada Ltd
Curated by
ChEMBL
Ligand
BDBM50319837
(4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...)
copy SMILES
copy InChI
Affinity Data
IC50: 9.5nM
Assay Description:
Antagonist activity at prostanoid EP4 receptor in human whole blood assessed as inhibition of TNFalpha-induced IP-10 release in presence EP4 agonist ...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
BindingDB Entry DOI:
10.7270/Q20P106K
PubMed