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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
13
hits in this display
Target
Corticotropin-releasing factor receptor 2
(Mus musculus)
A Subsidiary of Agouron Pharmaceuticals, Inc.
Curated by
ChEMBL
Ligand
BDBM32001
(7-Oxo-7H-benzo[e]perimidine-4-carboxylic acid | 7-...)
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Affinity Data
Ki: >1.00E+5nM
Assay Description:
Antagonistic activity against [125I]-Tyr-ovine CRF binding to Corticotropin releasing factor receptor 2 beta (30% inhibition at 100 uM)
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
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BindingDB Entry DOI:
10.7270/Q2TD9WJJ
PubMed
Target
Female germline-specific tumor suppressor gld-1
(Caenorhabditis elegans)
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM32001
(7-Oxo-7H-benzo[e]perimidine-4-carboxylic acid | 7-...)
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Affinity Data
IC50: 3.51E+3nM
Assay Description:
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...
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Target Info
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MMDB
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GoogleScholar
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BindingDB Entry DOI:
10.7270/Q2QC01ZW
PCBioAssay
Target
Glycoprotein 42
(Human herpesvirus 4 type 2)
Emory University Molecular Libraries Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM32001
(7-Oxo-7H-benzo[e]perimidine-4-carboxylic acid | 7-...)
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Affinity Data
IC50: 4.12E+3nM
Assay Description:
NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: Theodore Jardetzky; Northw...
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Target Info
PDB
MMDB
KEGG
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GoogleScholar
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BindingDB Entry DOI:
10.7270/Q2057DCW
PCBioAssay
Target
Heat shock protein HSP 90-alpha
(Homo sapiens (Human))
Emory University Molecular Libraries Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM32001
(7-Oxo-7H-benzo[e]perimidine-4-carboxylic acid | 7-...)
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Affinity Data
IC50: 5.22E+3nM
pH: 7.4 T: 2°C
Assay Description:
A fluorescence polarization based HTS assay has been developed and optimized for the identification of Hsp90 inhibitors by using tumor cell lysate Hs...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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BindingDB Entry DOI:
10.7270/Q2Q23XM6
PCBioAssay
Target
Protein Rev
(Human immunodeficiency virus 1)
The Scripps Research Institute Molecular Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM32001
(7-Oxo-7H-benzo[e]perimidine-4-carboxylic acid | 7-...)
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Affinity Data
IC50: 9.78E+3nM
Assay Description:
Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
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CHEMBL
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In Depth
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BindingDB Entry DOI:
10.7270/Q29W0CZG
PCBioAssay
Target
14-3-3 protein gamma
(Homo sapiens (Human))
Emory University Molecular Libraries Screening Center
Curated by
PubChem BioAssay
Ligand
BDBM32001
(7-Oxo-7H-benzo[e]perimidine-4-carboxylic acid | 7-...)
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Affinity Data
IC50: 5.00E+4nM
Assay Description:
NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN MLSCN Grant: 1 X01MH78953-01 The 14-3-3 pr...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
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BindingDB Entry DOI:
10.7270/Q2V986FT
PCBioAssay
Target
Bcl-2-related protein A1
(Mus musculus (Mouse))
Burnham Center for Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM32001
(7-Oxo-7H-benzo[e]perimidine-4-carboxylic acid | 7-...)
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Affinity Data
IC50: 1.00E+5nM
pH: 7.0 T: 2°C
Assay Description:
The aim is to identify chemical probes of Bfl-1 through a fluorescence polarization assay (FPA) using FITC-Bid BH3 peptide. 1) Dose-response curves c...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
KEGG
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BindingDB Entry DOI:
10.7270/Q2N014W6
PCBioAssay
Target
Bcl-2-related protein A1
(Mus musculus (Mouse))
Burnham Center for Chemical Genomics
Curated by
PubChem BioAssay
Ligand
BDBM32001
(7-Oxo-7H-benzo[e]perimidine-4-carboxylic acid | 7-...)
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Affinity Data
IC50: 1.00E+5nM
Assay Description:
Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (San Diego, CA) NIH Molecular Libraries Screening Cen...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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BindingDB Entry DOI:
10.7270/Q2K072NW
PCBioAssay
Target
Protein RecA
(Mycobacterium tuberculosis H37Rv)
Broad Institute
Curated by
PubChem BioAssay
Ligand
BDBM32001
(7-Oxo-7H-benzo[e]perimidine-4-carboxylic acid | 7-...)
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Affinity Data
EC50: 1.77E+3nM
Assay Description:
Keywords: GFP-RecA intein, protein splicing, refolding, reducing reagent, GFP fluorescence Assay Overview: M. tuberculosis harbors three inteins, whi...
More data for this Ligand-Target Pair
Target Info
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BindingDB Entry DOI:
10.7270/Q2DR2SX9
PCBioAssay
Target
Protein RecA
(Mycobacterium tuberculosis H37Rv)
Broad Institute
Curated by
PubChem BioAssay
Ligand
BDBM32001
(7-Oxo-7H-benzo[e]perimidine-4-carboxylic acid | 7-...)
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Affinity Data
EC50: 4.36E+3nM
Assay Description:
Keywords: GFP, refolding, reducing reagent, GFP fluorescence Assay Overview: M. tuberculosis harbors three inteins, which interrupt the DnaB, RecA, a...
More data for this Ligand-Target Pair
Target Info
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MMDB
KEGG
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BindingDB Entry DOI:
10.7270/Q2FN14NR
PCBioAssay
Target
Zinc finger protein mex-5
(Caenorhabditis elegans)
Broad Institute
Curated by
PubChem BioAssay
Ligand
BDBM32001
(7-Oxo-7H-benzo[e]perimidine-4-carboxylic acid | 7-...)
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Affinity Data
EC50: 3.19E+4nM
Assay Description:
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...
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Target Info
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BindingDB Entry DOI:
10.7270/Q2D798VP
PCBioAssay
Target
POsterior Segregation
(Caenorhabditis elegans)
Broad Institute
Curated by
PubChem BioAssay
Ligand
BDBM32001
(7-Oxo-7H-benzo[e]perimidine-4-carboxylic acid | 7-...)
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Affinity Data
EC50: 3.48E+4nM
Assay Description:
Broad Institute: MLPCN maternal gene expression Project ID: 2024 Keywords: Zinc finger, C. elegans, maternal gene expression, RNA-protein interac...
More data for this Ligand-Target Pair
Target Info
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BindingDB Entry DOI:
10.7270/Q28G8J4C
PCBioAssay
Target
Streptokinase A
(Streptococcus pyogenes M1 GAS)
Broad Institute
Curated by
PubChem BioAssay
Ligand
BDBM32001
(7-Oxo-7H-benzo[e]perimidine-4-carboxylic acid | 7-...)
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Affinity Data
EC50: 1.60E+4nM
Assay Description:
Keywords: Group A streptococcus, GAS, streptokinase, expression, virulence, inhibition, dose response, EC50 Assay Overview: The goal of this assa...
More data for this Ligand-Target Pair
Target Info
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BindingDB Entry DOI:
10.7270/Q2736PBV
PCBioAssay