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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
61
hits in this display
Target
Aldo-keto reductase family 1 member C3
(Homo sapiens (Human))
The University of Birmingham
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
Ki: 140nM ΔG°: -39.8kJ/mole
pH: 7.0 T: 2°C
Assay Description:
A fluorescence assay was used to determine the kinetic constants for the oxidation of 3alpha-androstanediol. The fluorescence emission of NADPH at 45...
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BindingDB Entry DOI:
10.7270/Q2JS9NPR
PubMed
PDB
3D Structure (crystal)
Target
Prostaglandin G/H synthase 1
(Homo sapiens (Human))
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM85514
(CAS_530-78-9 | Flufenamate | NSC_27881)
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Affinity Data
Ki: 3.00E+3nM
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BindingDB Entry DOI:
10.7270/Q21G0JT4
PubMed
Target
Aldo-keto reductase family 1 member C3
(Homo sapiens (Human))
The University of Birmingham
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
Ki: 3.10E+3nM ΔG°: -32.0kJ/mole
pH: 7.0 T: 2°C
Assay Description:
Enzyme activity was measured in the reductive direction against varying concentrations of androsterone. Initial velocities were measured by observing...
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BindingDB Entry DOI:
10.7270/Q2JS9NPR
PubMed
PDB
3D Structure (crystal)
Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM85514
(CAS_530-78-9 | Flufenamate | NSC_27881)
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Affinity Data
Ki: 9.30E+3nM
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BindingDB Entry DOI:
10.7270/Q21G0JT4
PubMed
Target
Fatty acid-binding protein, intestinal
(Homo sapiens (Human))
Monash University
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
Ki: 1.55E+4nM ΔG°: -52.1kJ/mole
T: 2°C
Assay Description:
Briefly, steady-state fluorescence spectra of ANS binding was monitored by measuring the increase in fluorescence signal between 450?550 nm following...
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BindingDB Entry DOI:
10.7270/Q2348J4C
PubMed
Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 16nM
Assay Description:
Inhibition of COX2 expressed in baculovirus infected SF-21 cells assessed as formation of PGH2 from PGG2 using arachidonic acid as substrate preincub...
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BindingDB Entry DOI:
10.7270/Q2C24XGP
PubMed
PDB
3D Structure (crystal)
Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 16nM
Assay Description:
Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...
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BindingDB Entry DOI:
10.7270/Q27W6B22
US Patent
PDB
3D Structure (crystal)
Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 20nM
Assay Description:
Inhibition of recombinant COX2
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BindingDB Entry DOI:
10.7270/Q24M95JQ
PubMed
PDB
3D Structure (crystal)
Target
Aldo-keto reductase family 1 member C3
(Homo sapiens (Human))
The University of Birmingham
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 50nM
Assay Description:
Inhibition of recombinant AKR1C3 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assay
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BindingDB Entry DOI:
10.7270/Q2C24XGP
PubMed
PDB
3D Structure (crystal)
Target
Aldo-keto reductase family 1 member C3
(Homo sapiens (Human))
The University of Birmingham
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 51nM
Assay Description:
Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...
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BindingDB Entry DOI:
10.7270/Q27W6B22
US Patent
PDB
3D Structure (crystal)
Target
Aldo-keto reductase family 1 member C3
(Homo sapiens (Human))
The University of Birmingham
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 51nM
Assay Description:
Inhibition of AKR1C3 by fluorimetric method
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BindingDB Entry DOI:
10.7270/Q24J0FD4
PubMed
PDB
3D Structure (crystal)
Target
Aldo-keto reductase family 1 member C2
(Homo sapiens (Human))
The Trustees of the University of Pennsylvania
US Patent
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 370nM
Assay Description:
Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...
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BindingDB Entry DOI:
10.7270/Q27W6B22
US Patent
PDB
3D Structure (crystal)
Target
Aldo-keto reductase family 1 member C2
(Homo sapiens (Human))
The Trustees of the University of Pennsylvania
US Patent
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 370nM
Assay Description:
Inhibition of recombinant AKR1C2 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assay
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BindingDB Entry DOI:
10.7270/Q2C24XGP
PubMed
PDB
3D Structure (crystal)
Target
Aldo-keto reductase family 1 member C2
(Homo sapiens (Human))
The Trustees of the University of Pennsylvania
US Patent
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 370nM
Assay Description:
Inhibition of AKR1C2 by fluorimetric method
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BindingDB Entry DOI:
10.7270/Q24J0FD4
PubMed
PDB
3D Structure (crystal)
Target
Aldo-keto reductase family 1 member C3
(Homo sapiens (Human))
The University of Birmingham
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 410nM
Assay Description:
Inhibition of AKR1C3 (unknown origin)
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BindingDB Entry DOI:
10.7270/Q2H133CX
PubMed
PDB
3D Structure (crystal)
Target
Aldo-keto reductase family 1 member C3
(Homo sapiens (Human))
The University of Birmingham
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 410nM
Assay Description:
Inhibition of human recombinant N-terminal His6-tagged AKR1C3 expressed in Escherichia coli BL21(DE3) cells using 8-Acetyl-2,3,5,6-tetrahydro-1H,4H-1...
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BindingDB Entry DOI:
10.7270/Q28K7B6F
PubMed
PDB
3D Structure (crystal)
Target
Aldo-keto reductase family 1 member C3
(Homo sapiens (Human))
The University of Birmingham
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 440nM
Assay Description:
Inhibition of recombinant N-terminal GST-tagged human AKR1C3 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells using S-tetralol as substrat...
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BindingDB Entry DOI:
10.7270/Q2S46VMT
PubMed
PDB
3D Structure (crystal)
Target
Aldo-keto reductase family 1 member C3
(Homo sapiens (Human))
The University of Birmingham
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 440nM
Assay Description:
Inhibition of type-1 human steroid 5-alpha-reductase
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BindingDB Entry DOI:
10.7270/Q2Q52S4X
PubMed
PDB
3D Structure (crystal)
Target
Aldo-keto reductase family 1 member C2
(Homo sapiens (Human))
The Trustees of the University of Pennsylvania
US Patent
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 530nM
Assay Description:
Antagonistic activity against TP-receptor by inhibition of U 46619-induced contraction of isolated guinea pig trachea
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BindingDB Entry DOI:
10.7270/Q2Q52S4X
PubMed
PDB
3D Structure (crystal)
Target
Aldo-keto reductase family 1 member C2
(Homo sapiens (Human))
The Trustees of the University of Pennsylvania
US Patent
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 530nM
Assay Description:
Inhibition of recombinant N-terminal GST-tagged human AKR1C2 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells using S-tetralol as substrat...
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BindingDB Entry DOI:
10.7270/Q2S46VMT
PubMed
PDB
3D Structure (crystal)
Target
Aldo-keto reductase family 1 member C2
(Homo sapiens (Human))
The Trustees of the University of Pennsylvania
US Patent
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 630nM
Assay Description:
Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...
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BindingDB Entry DOI:
10.7270/Q27W6B22
US Patent
PDB
3D Structure (crystal)
Target
Aldo-keto reductase family 1 member B10
(Homo sapiens (Human))
Universit£ degli Studi di Messina
Curated by
ChEMBL
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 760nM
Assay Description:
Inhibition of wild-type N-terminal 6-His tagged AKR1B10 (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as pyridine-3-aldehyde redu...
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BindingDB Entry DOI:
10.7270/Q2D79D4X
PubMed
PDB
3D Structure (crystal)
Target
Aldo-keto reductase family 1 member B10
(Homo sapiens (Human))
Universit£ degli Studi di Messina
Curated by
ChEMBL
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 760nM
Assay Description:
Inhibition of recombinant human N-terminal His6-tagged AKR1B10 expressed in Escherichia coli BL21 (DE3) pLysS cells by pyridine-3-aldehyde reductase ...
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BindingDB Entry DOI:
10.7270/Q2XG9V5T
PubMed
PDB
3D Structure (crystal)
Target
Aldo-keto reductase family 1 member C1
(Homo sapiens (Human))
The Trustees of the University of Pennsylvania
US Patent
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 980nM
Assay Description:
Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...
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BindingDB Entry DOI:
10.7270/Q27W6B22
US Patent
PDB
3D Structure (crystal)
Target
Aldo-keto reductase family 1 member C3
(Homo sapiens (Human))
The University of Birmingham
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 1.65E+3nM
Assay Description:
Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...
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BindingDB Entry DOI:
10.7270/Q27W6B22
US Patent
PDB
3D Structure (crystal)
Target
Myeloperoxidase
(Homo sapiens (Human))
Universit£ Libre de Bruxelles
Curated by
ChEMBL
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 1.80E+3nM
Assay Description:
Inhibition of chlorinating activity of recombinant myeloperoxidase by taurine assay
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BindingDB Entry DOI:
10.7270/Q2HH6KWD
PubMed
Target
Prostaglandin G/H synthase 1
(Homo sapiens (Human))
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 2.23E+3nM
Assay Description:
Inhibition of recombinant COX1
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BindingDB Entry DOI:
10.7270/Q24M95JQ
PubMed
Target
Prostaglandin G/H synthase 1
(Homo sapiens (Human))
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 2.23E+3nM
Assay Description:
Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...
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BindingDB Entry DOI:
10.7270/Q27W6B22
US Patent
Target
Aldo-keto reductase family 1 member C1
(Homo sapiens (Human))
The Trustees of the University of Pennsylvania
US Patent
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 2.64E+3nM
Assay Description:
Inhibition of human recombinant N-terminal His6-tagged AKR1C1 expressed in Escherichia coli BL21(DE3) cells using 8-Acetyl-2,3,5,6-tetrahydro-1H,4H-1...
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BindingDB Entry DOI:
10.7270/Q28K7B6F
PubMed
PDB
3D Structure (crystal)
Target
Aldo-keto reductase family 1 member C1
(Homo sapiens (Human))
The Trustees of the University of Pennsylvania
US Patent
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 2.64E+3nM
Assay Description:
Inhibition of AKR1C1 (unknown origin)
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BindingDB Entry DOI:
10.7270/Q2H133CX
PubMed
PDB
3D Structure (crystal)
Target
Transthyretin
(Homo sapiens (Human))
University of California
Curated by
ChEMBL
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 2.90E+3nM
pH: 4.4
Assay Description:
Inhibition of human transthyretin fibril formation at pH 4.4 after 72 hrs
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BindingDB Entry DOI:
10.7270/Q2B27W52
PubMed
PDB
3D Structure (crystal)
Target
Prostaglandin G/H synthase 1
(Homo sapiens (Human))
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by
PDSP K
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Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 3.00E+3nM
Assay Description:
Inhibition of COX1 (unknown origin)
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BindingDB Entry DOI:
10.7270/Q2H133CX
PubMed
Target
Aldo-keto reductase family 1 member C2
(Homo sapiens (Human))
The Trustees of the University of Pennsylvania
US Patent
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 3.14E+3nM
Assay Description:
Inhibition of human recombinant N-terminal His6-tagged AKR1C2 expressed in Escherichia coli BL21(DE3) cells using 8-Acetyl-2,3,5,6-tetrahydro-1H,4H-1...
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BindingDB Entry DOI:
10.7270/Q28K7B6F
PubMed
PDB
3D Structure (crystal)
Target
Aldo-keto reductase family 1 member C2
(Homo sapiens (Human))
The Trustees of the University of Pennsylvania
US Patent
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 3.14E+3nM
Assay Description:
Inhibition of AKR1C2 (unknown origin)
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BindingDB Entry DOI:
10.7270/Q2H133CX
PubMed
PDB
3D Structure (crystal)
Target
Aldo-keto reductase family 1 member C3
(Homo sapiens (Human))
The University of Birmingham
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 8.63E+3nM
Assay Description:
Thromboxane (TXA2) receptor antagonist activity using human platelet
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BindingDB Entry DOI:
10.7270/Q2Q52S4X
PubMed
PDB
3D Structure (crystal)
Target
Prostaglandin G/H synthase 2
(Homo sapiens (Human))
St. Bartholomew's and the Royal London School of Medicine and Dentistry
Curated by
PDSP K
i
Database
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 9.30E+3nM
Assay Description:
Inhibition of COX2 (unknown origin)
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BindingDB Entry DOI:
10.7270/Q2H133CX
PubMed
PDB
3D Structure (crystal)
Target
Prostaglandin G/H synthase 1
(Ovis aries (Sheep))
University of Torino
Curated by
ChEMBL
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 1.40E+4nM
Assay Description:
Thromboxane (TXA2) receptor antagonist activity using human platelet
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BindingDB Entry DOI:
10.7270/Q2Q52S4X
PubMed
Target
Aldo-keto reductase family 1 member B1
(Homo sapiens (Human))
Universit£ degli Studi di Messina
Curated by
ChEMBL
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 4.10E+4nM
Assay Description:
Inhibition of human AR by fluorescence assay
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BindingDB Entry DOI:
10.7270/Q2D79D4X
PubMed
Target
Androgen receptor
(Homo sapiens (Human))
University of British Columbia
Curated by
ChEMBL
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 5.00E+4nM
Assay Description:
Transcriptional activity at human androgen receptor BF3 site stably transfected in eGFP-expressing human LNCAP cells after 5 days by fluorometric ana...
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BindingDB Entry DOI:
10.7270/Q2QC03X8
PubMed
PDB
3D Structure (crystal)
Target
Transcriptional enhancer factor TEF-3
(Homo sapiens)
Shanghai Institute of Materia Medica
Curated by
ChEMBL
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 5.40E+4nM
Assay Description:
Inhibition of N-terminal His6-tagged human TEAD4 YAP binding domain (217 to 434 residues) expressed in Escherichia coli C43 (DE3) cells assessed redu...
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BindingDB Entry DOI:
10.7270/Q2VX0KWC
PubMed
Target
Transient receptor potential cation channel subfamily M member 2
(Homo sapiens (Human))
TBA
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 7.00E+4nM
Assay Description:
Inhibition of human TRPM2 expressed in HEK293T cells assessed as blocked of ADPR-activated current by whole cell patch clamp electrophysiology
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BindingDB Entry DOI:
10.7270/Q2HT2T5G
PubMed
Target
Aldo-keto reductase family 1 member B10
(Homo sapiens (Human))
Universit£ degli Studi di Messina
Curated by
ChEMBL
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 9.60E+4nM
Assay Description:
Inhibition of recombinant human N-terminal His6-tagged AKR1B10 expressed in Escherichia coli BL21 cells using all-trans-retinal as substrate incubate...
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BindingDB Entry DOI:
10.7270/Q2XG9V5T
PubMed
PDB
3D Structure (crystal)
Target
Cytochrome c oxidase subunit 2
(Homo sapiens (Human))
University of Torino
Curated by
ChEMBL
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 1.00E+5nM
Assay Description:
Thromboxane (TXA2) receptor antagonist activity using human platelet
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BindingDB Entry DOI:
10.7270/Q2Q52S4X
PubMed
Target
Aldo-keto reductase family 1 member C4
(Homo sapiens (Human))
University of Auckland
Curated by
ChEMBL
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 1.00E+5nM
Assay Description:
Inhibition of human recombinant N-terminal His6-tagged AKR1C4 expressed in Escherichia coli BL21(DE3) cells using 8-Acetyl-2,3,5,6-tetrahydro-1H,4H-1...
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BindingDB Entry DOI:
10.7270/Q28K7B6F
PubMed
Target
Aldo-keto reductase family 1 member C4
(Homo sapiens (Human))
University of Auckland
Curated by
ChEMBL
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 1.00E+5nM
Assay Description:
Inhibition of AKR1C4 (unknown origin)
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BindingDB Entry DOI:
10.7270/Q2H133CX
PubMed
Target
Aldo-keto reductase family 1 member B1
(Homo sapiens (Human))
Universit£ degli Studi di Messina
Curated by
ChEMBL
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 1.00E+5nM
Assay Description:
In vitro inhibition of rabbit lens aldose reductase.
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BindingDB Entry DOI:
10.7270/Q23R0RWW
PubMed
Target
Transcription factor SOX-18
(Mus musculus (Mouse))
The University of Queensland
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 2.20E+5nM
pH: 7.5 T: 2°C
Assay Description:
The DNA-binding competition assay was performed in 25 μL, in black 384-well plates, using either 30 mM HEPES (N-2-Hydroxyethylpiperazine-N'-2-Etha...
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BindingDB Entry DOI:
10.7270/Q2MP5252
PubMed
Target
Transcription factor SOX-18
(Human)
TBA
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
IC50: 2.20E+5nM
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Target
Androgen receptor
(Homo sapiens (Human))
University of British Columbia
Curated by
ChEMBL
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
EC50: 6.70E+4nM
Assay Description:
AR functionality was determined by fluorescence polarization (excitation @485 nm, emission @ 530 nm) assay, which measures fluorescently labeled SRC2...
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BindingDB Entry DOI:
10.7270/Q2V986DC
PubMed
PDB
3D Structure (crystal)
Target
Potassium channel subfamily K member 18
(Homo sapiens (Human))
Pfizer Inc.
Curated by
ChEMBL
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
EC50: >1.00E+5nM
Assay Description:
Activation of human TRESK channel relative to control
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BindingDB Entry DOI:
10.7270/Q2T72KDN
PubMed
Target
Transient receptor potential cation channel subfamily A member 1
(Homo sapiens (Human))
University of Hull
Curated by
ChEMBL
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
EC50: 6.92E+3nM
Assay Description:
Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay
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BindingDB Entry DOI:
10.7270/Q2F76GWS
PubMed
Target
Transient receptor potential cation channel subfamily A member 1
(Homo sapiens (Human))
University of Hull
Curated by
ChEMBL
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
EC50: 7.00E+3nM
Assay Description:
Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay
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BindingDB Entry DOI:
10.7270/Q2F76GWS
PubMed
Target
Transient receptor potential cation channel subfamily A member 1
(Homo sapiens (Human))
University of Hull
Curated by
ChEMBL
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
EC50: 2.40E+4nM
Assay Description:
Agonist activity at human TRPA1 in WI38 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay
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BindingDB Entry DOI:
10.7270/Q2F76GWS
PubMed
Target
Transcriptional enhancer factor TEF-3
(Homo sapiens)
Shanghai Institute of Materia Medica
Curated by
ChEMBL
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
Kd: 7.30E+4nM
Assay Description:
Binding affinity to N-terminal His6 tagged human TEAD4 (217 to 434 residues) expressed in Escherichia coli C43 (DE3) cells incubated for 30 mins by i...
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BindingDB Entry DOI:
10.7270/Q2VX0KWC
PubMed
Target
Taste receptor type 2 member 14
(Homo sapiens (Human))
TBA
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
EC50: 430nM
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Potassium channel subfamily K member 2
(Homo sapiens (Human))
Universit£ Clermont Auvergne
Curated by
ChEMBL
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
EC50: 1.00E+5nM
Assay Description:
Activation of TREK1 (unknown origin) expressed in COS7 cells assessed as increase in whole cell currents at +50 mV relative to control
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BindingDB Entry DOI:
10.7270/Q2319XSS
PubMed
Target
Transcriptional enhancer factor TEF-3
(Homo sapiens)
Shanghai Institute of Materia Medica
Curated by
ChEMBL
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
Kd: 7.30E+4nM
Assay Description:
Binding affinity to N-terminal His6-tagged human TEAD4 YAP binding domain (217 to 434 residues) expressed in Escherichia coli C43 (DE3) cells by ITC ...
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Article
BindingDB Entry DOI:
10.7270/Q2QN6BC1
PubMed
Target
Transthyretin
(Homo sapiens (Human))
University of California
Curated by
ChEMBL
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
Kd: 30nM
Assay Description:
Binding affinity to wild type TTR (unknown origin) expressed in Escherichia coli BL21/DE3 by Circular dichroism spectroscopy
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Target Info
PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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MCE
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BindingDB Entry DOI:
10.7270/Q2CN77M6
PubMed
PDB
3D Structure (crystal)
Target
Potassium channel subfamily K member 18
(Homo sapiens (Human))
Pfizer Inc.
Curated by
ChEMBL
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
EC50: 4.74E+5nM
Assay Description:
Activation of human TRESK channel expressed in HEK293 cells assessed as induction of channel current by whole cell patch clamp assay
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BindingDB Entry DOI:
10.7270/Q2T72KDN
PubMed
Target
Acid-sensing ion channel 5
(Rattus norvegicus)
RWTH Aachen University
Curated by
ChEMBL
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
EC50: 2.60E+6nM
Assay Description:
Binding affinity to rat bile acid-sensitive ion channel expressed in xenopus oocytes
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BindingDB Entry DOI:
10.7270/Q2M04786
PubMed
Target
Transcriptional enhancer factor TEF-3
(Homo sapiens)
Shanghai Institute of Materia Medica
Curated by
ChEMBL
Ligand
BDBM17636
(2-{[3-(trifluoromethyl)phenyl]amino}benzoic acid |...)
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Affinity Data
Kd: 8.40E+4nM
Assay Description:
Binding affinity to N-terminal His6 tagged human TEAD4-YBD (217 to 434 residues) expressed in Escherichia coli C43 (DE3) cells by SPR analysis
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Target Info
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BindingDB Entry DOI:
10.7270/Q2VX0KWC
PubMed
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