Compile Data Set for Download or QSAR
Found 47 Enz. Inhib. hit(s) with Target = 'Dihydroorotate dehydrogenase (quinone), mitochondrial [30-395]'
LigandPNGBDBM16117(3-{[2,3,5,6-tetrafluoro-4-(2-methoxyphenyl)phenyl]...)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8BQ4PubMed
LigandPNGBDBM16115(3-{[4-(3-ethoxyphenyl)-2,6-difluorophenyl]carbamoy...)copy SMILEScopy InChI
Affinity DataIC50: 3nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8BQ4PubMed
LigandPNGBDBM16112(2-{[2,3,5,6-tetrafluoro-4-(2-methoxyphenyl)phenyl]...)copy SMILEScopy InChI
Affinity DataIC50: 8nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8BQ4PubMed
LigandPNGBDBM15339(6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methyl-qui...)copy SMILEScopy InChI
Affinity DataIC50: 8nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
LigandPNGBDBM16116(3-{[4-(2-ethoxyphenyl)-2,6-difluorophenyl]carbamoy...)copy SMILEScopy InChI
Affinity DataIC50: 9nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8BQ4PubMed
LigandPNGBDBM16120(4-{[4-(2-ethoxyphenyl)-2,6-difluorophenyl]carbamoy...)copy SMILEScopy InChI
Affinity DataIC50: 10nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8BQ4PubMed
LigandPNGBDBM16121(4-({2,6-difluoro-4-[3-(trifluoromethoxy)phenyl]phe...)copy SMILEScopy InChI
Affinity DataIC50: 10nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8BQ4PubMed
LigandPNGBDBM16118(3-{[3-chloro-4-(2-methoxyphenyl)phenyl]carbamoyl}t...)copy SMILEScopy InChI
Affinity DataIC50: 12nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8BQ4PubMed
LigandPNGBDBM16125(4-{[4-(3-ethoxyphenyl)-2,6-difluorophenyl]carbamoy...)copy SMILEScopy InChI
Affinity DataIC50: 16nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8BQ4PubMed
LigandPNGBDBM16114(3-{[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl}t...)copy SMILEScopy InChI
Affinity DataIC50: 44nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [30-395](Rattus norvegicus (rat))
University of Copenhagen

LigandPNGBDBM15339(6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methyl-qui...)copy SMILEScopy InChI
Affinity DataIC50: 127nMpH: 8.0 T: 2°CAssay Description:To determine the inhibitory potency of the drugs, the initial velocity of the DHODR-catalyzed reaction at saturating concentrations of DHO (1 mM) and...More data for this Ligand-Target Pair
LigandPNGBDBM16111(2-{[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl}c...)copy SMILEScopy InChI
Affinity DataIC50: 134nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8BQ4PubMed
LigandPNGBDBM16113(3-[(4-phenylphenyl)carbamoyl]thiophene-2-carboxyli...)copy SMILEScopy InChI
Affinity DataIC50: 303nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8BQ4PubMed
LigandPNGBDBM16126(4-{[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl}f...)copy SMILEScopy InChI
Affinity DataIC50: 340nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8BQ4PubMed
LigandPNGBDBM16109(2-[(4-phenylphenyl)carbamoyl]cyclopent-1-ene-1-car...)copy SMILEScopy InChI
Affinity DataIC50: 410nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8BQ4PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [30-395](Rattus norvegicus (rat))
University of Copenhagen

LigandPNGBDBM16301(3-[4-(4-chlorophenyl)cyclohexyl]naphthalene-1,2,4-...)copy SMILEScopy InChI
Affinity DataIC50: 904nMpH: 8.0 T: 2°CAssay Description:To determine the inhibitory potency of the drugs, the initial velocity of the DHODR-catalyzed reaction at saturating concentrations of DHO (1 mM) and...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FB5163PubMed
LigandPNGBDBM16122(3-{[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl}t...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8BQ4PubMed
LigandPNGBDBM16123(3-{[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl}t...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8BQ4PubMed
LigandPNGBDBM16124(4-{[2-fluoro-4-(3-methoxyphenyl)phenyl]carbamoyl}t...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8BQ4PubMed
LigandPNGBDBM16119(4-[(4-phenylphenyl)carbamoyl]thiophene-3-carboxyli...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8BQ4PubMed
LigandPNGBDBM15348(ChemBridge compound no. 3 | N-(2-fluorophenyl)naph...)copy SMILEScopy InChI
Affinity DataIC50: 3.40E+4nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0JH3PubMed
LigandPNGBDBM15345(Asinex compound no. 1 | N-(2,4-dichlorophenyl)naph...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0JH3PubMed
LigandPNGBDBM15354(Asinex compound no. 9 | N-(3,4-dichlorophenyl)-2-m...)copy SMILEScopy InChI
Affinity DataIC50: 7.20E+4nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0JH3PubMed
LigandPNGBDBM28842(N-(3-fluoro-4-methylphenyl)-5-methyl-[1,2,4]triazo...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN653CPubMed
LigandPNGBDBM28843(N-[3-fluoro-4-(trifluoromethyl)phenyl]-5-methyl-[1...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN653CPubMed
LigandPNGBDBM28840(N-(3,4-dimethylphenyl)-5-methyl-[1,2,4]triazolo[1,...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN653CPubMed
LigandPNGBDBM28839(5-methyl-N-[4-methyl-3-(trifluoromethyl)phenyl]-[1...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN653CPubMed
LigandPNGBDBM28838(N-[4-bromo-3-(trifluoromethyl)phenyl]-5-methyl-[1,...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN653CPubMed
LigandPNGBDBM28837(N-[4-chloro-3-(trifluoromethyl)phenyl]-5-methyl-[1...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN653CPubMed
LigandPNGBDBM28819(5-methyl-N-[4-(trifluoromethoxy)phenyl]-[1,2,4]tri...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN653CPubMed
LigandPNGBDBM28817(5-methyl-N-[4-(trifluoromethyl)phenyl]-[1,2,4]tria...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN653CPubMedDrugBank
LigandPNGBDBM28815(N-(4-bromophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]p...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN653CPubMed
LigandPNGBDBM28814(N-(4-chlorophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN653CPubMed
LigandPNGBDBM28810(N-(3-chlorophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN653CPubMed
LigandPNGBDBM15353(2-methyl-N-(naphthalen-1-yl)-3-nitrobenzamide | Ch...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0JH3PubMed
LigandPNGBDBM15349(Asinex compound no. 4 | N-(3-bromophenyl)-2-methyl...)copy SMILEScopy InChI
Affinity DataIC50: 1.05E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0JH3PubMed
LigandPNGBDBM15357(3-(2-methoxyphenyl)-1-naphthalen-1-ylurea | ChemBr...)copy SMILEScopy InChI
Affinity DataIC50: 1.12E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0JH3PubMed
LigandPNGBDBM15350(ChemBridge compound no. 5 | N-(3-chloro-4-fluoroph...)copy SMILEScopy InChI
Affinity DataIC50: 1.16E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0JH3PubMed
LigandPNGBDBM15358(3-(4-chlorophenyl)-1-quinolin-8-ylurea | Asinex co...)copy SMILEScopy InChI
Affinity DataIC50: 1.16E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0JH3PubMed
LigandPNGBDBM15355(2-methyl-3-nitro-N-[3-(trifluoromethyl)phenyl]benz...)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0JH3PubMed
LigandPNGBDBM24400(5-methyl-N-(naphthalen-2-yl)-[1,2,4]triazolo[1,5-a...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN653CPubMed
LigandPNGBDBM24412(5-methyl-N-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN653CPubMed
LigandPNGBDBM15352(ChemBridge compound no. 7 | N-(3,4-difluorophenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0JH3PubMed
LigandPNGBDBM14711(Asinex compound no. 6 | N-(3,5-Dichlorophenyl)-2-m...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0JH3PubMed
LigandPNGBDBM24413(JMC521864 Compund DSM2 | N-(anthracen-2-yl)-5-meth...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN653CPubMedDrugBank
LigandPNGBDBM14710(ChemBridge compound no. 2 | N-(4-Bromo-2-methylphe...)copy SMILEScopy InChI
Affinity DataIC50: 2.10E+5nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0JH3PubMed
LigandPNGBDBM15356(1-naphthalen-1-yl-3-[2-(trifluoromethyl)phenyl]ure...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+6nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0JH3PubMed