Compile Data Set for Download or QSAR
Found 177 Enz. Inhib. hit(s) with Target = 'Dual specificity mitogen-activated protein kinase kinase 7'
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50463479(CHEMBL4249925)copy SMILEScopy InChI
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of MKK7 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZC85HXPubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50463484(CHEMBL4248525)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of MKK7 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZC85HXPubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50553869(CHEMBL4764965)copy SMILES
Affinity DataIC50: 0.600nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50559800(CHEMBL3329977)copy SMILES
Affinity DataIC50: 1.90nMAssay Description:Inhibition of MEK7 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028W77PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50594444(CHEMBL5174214)copy SMILES
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2765KB8PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50594445(CHEMBL5195838)copy SMILES
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2765KB8PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50553870(CHEMBL4749823)copy SMILES
Affinity DataIC50: 5nMAssay Description:Inhibition of MEK7 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50553870(CHEMBL4749823)copy SMILES
Affinity DataIC50: 5nMAssay Description:Inhibition of MAP2K7 (unknown origin) using JNK peptide KFMMTPYVVTR incubated for 30 mins measured by multimode reader based ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50206444(CHEMBL3901151)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of MEK7 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028W77PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50553869(CHEMBL4764965)copy SMILES
Affinity DataIC50: 6.5nMAssay Description:Inhibition of MAP2K7 (unknown origin) using JNK peptide KFMMTPYVVTR incubated for 30 mins measured by multimode reader based ADP-glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50615119(CHEMBL5284723)copy SMILES
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50559801(CHEMBL4787266)copy SMILES
Affinity DataIC50: 14nMAssay Description:Inhibition of MEK7 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028W77PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50594446(CHEMBL5169325)copy SMILES
Affinity DataIC50: 30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2765KB8PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50258966(CHEMBL4071151)copy SMILEScopy InChI
Affinity DataIC50: 30nMMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50615123(CHEMBL5283781)copy SMILES
Affinity DataIC50: 42nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50615102(CHEMBL5271442)copy SMILES
Affinity DataIC50: 60nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50615113(CHEMBL5267499)copy SMILES
Affinity DataIC50: 66nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50615120(CHEMBL5279577)copy SMILES
Affinity DataIC50: 74nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50577689(CHEMBL4866649)copy SMILES
Affinity DataIC50: 96nMAssay Description:Inhibition of human recombinant full length N-terminal GST tagged MEK7 expressed in Sf21 cells using JNK1 as substrate pre-incubated for 30 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C50MCPubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50615122(CHEMBL5267684)copy SMILES
Affinity DataIC50: 110nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50615118(CHEMBL5271266)copy SMILES
Affinity DataIC50: 110nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50269615(CHEMBL4095253)copy SMILEScopy InChI
Affinity DataIC50: 189nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged MKK7beta (2 to end residues) expressed in Escherichia coli preincubated for 5 mins followed by ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7M50PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50504351(CHEMBL100206)copy SMILEScopy InChI
Affinity DataIC50: 230nMAssay Description:Inhibition of MEK7 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028W77PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM31085(1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluorom...)copy SMILEScopy InChI
Affinity DataIC50: 260nMMore data for this Ligand-Target Pair
In DepthDetails
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50615129(CHEMBL5277855)copy SMILES
Affinity DataIC50: 260nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50615109(CHEMBL5282673)copy SMILES
Affinity DataIC50: 260nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50615110(CHEMBL5271906)copy SMILES
Affinity DataIC50: 270nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50336457((3S,5Z,8S,9R,11E)-8,9,16-trihydroxy-14-methoxy-3-m...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Inhibition of MEK7More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92CGPPubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50615128(CHEMBL5272546)copy SMILES
Affinity DataIC50: 300nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50615130(CHEMBL5271519)copy SMILES
Affinity DataIC50: 360nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50615121(CHEMBL5271334)copy SMILES
Affinity DataIC50: 360nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50615131(CHEMBL5273066)copy SMILES
Affinity DataIC50: 410nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50615103(CHEMBL5273762)copy SMILES
Affinity DataIC50: 420nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50577661(CHEMBL4879048)copy SMILES
Affinity DataIC50: 540nMAssay Description:Inhibition of human recombinant full length N-terminal GST tagged MEK7 expressed in Sf21 cells using JNK1 as substrate pre-incubated for 30 mins foll...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C50MCPubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI
Affinity DataIC50: 571nMAssay Description:Inhibition of human MKK7 using JNK as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5KB8PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50615126(CHEMBL5266940)copy SMILES
Affinity DataIC50: 800nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50577671(CHEMBL4872723)copy SMILES
Affinity DataIC50: 840nMAssay Description:Inhibition of human recombinant full length N-terminal GST tagged MEK7 expressed in Sf21 cells using JNK1 as substrate pre-incubated for 30 mins foll...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C50MCPubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50277910(4-(4-(2-(cyclopentylamino)pyrimidin-4-yl)-1H-pyraz...)copy SMILEScopy InChI
Affinity DataIC50: 860nMAssay Description:Inhibition of MKK7betaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4H9DPubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50615108(CHEMBL5287907)copy SMILES
Affinity DataIC50: 900nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50577686(CHEMBL4865159)copy SMILES
Affinity DataIC50: 920nMAssay Description:Inhibition of human recombinant full length N-terminal GST tagged MEK7 expressed in Sf21 cells using JNK1 as substrate pre-incubated for 30 mins foll...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C50MCPubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50615115(CHEMBL5278028)copy SMILES
Affinity DataIC50: 930nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50192071((13R,15S)-13-methyl-16-oxa-8,9,12,22,24-pentaazahe...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of MKK7betaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K35VF0PubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50615117(CHEMBL5266650)copy SMILES
Affinity DataIC50: 1.10E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50615124(CHEMBL5281707)copy SMILES
Affinity DataIC50: 1.20E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50615112(CHEMBL5274241)copy SMILES
Affinity DataIC50: 1.20E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50615114(CHEMBL5284495)copy SMILES
Affinity DataIC50: 1.20E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI
Affinity DataIC50: 1.28E+3nMAssay Description:Inhibition of human MKK7 using JNK as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W380MTPubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50577665(CHEMBL4871202)copy SMILES
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human recombinant full length N-terminal GST tagged MEK7 expressed in Sf21 cells using JNK1 as substrate pre-incubated for 30 mins foll...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C50MCPubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50577688(CHEMBL4875545)copy SMILES
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human recombinant full length N-terminal GST tagged MEK7 expressed in Sf21 cells using JNK1 as substrate pre-incubated for 30 mins foll...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C50MCPubMed
TargetDual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50042034((5Z)-7-Oxozeaenol | 5Z-7-Oxozeaenol | CHEBI:67559 ...)copy SMILEScopy InChI
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of MAP2K7 (unknown origin) using unphosphorylated GST-tagged JNK1 substrate protein assessed as phosphorylation by ELISAMore data for this Ligand-Target Pair
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