Compile Data Set for Download or QSAR
Found 200 Enz. Inhib. hit(s) with Target = 'Enoyl-[acyl-carrier-protein] reductase [NADH] FabI'
LigandPNGBDBM8726(5-chloro-2-(2,4-dichlorophenoxy)phenol | CHEMBL849...)copy SMILEScopy InChI
Affinity DataKi:  0.00700nMMore data for this Ligand-Target Pair
LigandPNGBDBM36537(2-phenoxylphenol | PT51 | US10071965, Compound PT5...)copy SMILEScopy InChI
Affinity DataKi:  0.5nMMore data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM36538(5-fluoro-2-phenoxylphenol | PT55 | US10071965, Com...)copy SMILEScopy InChI
Affinity DataKi:  0.700nMMore data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM36539(5-chloro-2-phenoxylphenol | PT52 | US10071965, Com...)copy SMILEScopy InChI
Affinity DataKi:  1.10nMMore data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM36542(5-methyl-2-phenoxylphenol | PT53 | US10071965, Com...)copy SMILEScopy InChI
In DepthDetails
LigandPNGBDBM190661(PT166)copy SMILEScopy InChI
Affinity DataKi:  7nMpH: 7.5Assay Description:Kinetics were performed on a Cary 100 spectrophotometer (Varian) at 20 °C. Reaction velocities were measured by monitoring the oxidation of NAD(P)H t...More data for this Ligand-Target Pair
LigandPNGBDBM231620(CG400549 | US10071965, Compound CG400549)copy SMILEScopy InChI
Affinity DataKi:  81.9nMpH: 7.5Assay Description:Kinetics were performed on a Cary 100 spectrophotometer (Varian) at 20 °C. Reaction velocities were measured by monitoring the oxidation of NAD(P)H t...More data for this Ligand-Target Pair
LigandPNGBDBM190652(LOX inhibitor, 13 | PT171)copy SMILEScopy InChI
Affinity DataKi:  95.7nMpH: 7.5Assay Description:Kinetics were performed on a Cary 100 spectrophotometer (Varian) at 20 °C. Reaction velocities were measured by monitoring the oxidation of NAD(P)H t...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41Q89PubMed
LigandPNGBDBM190654(PT173)copy SMILEScopy InChI
Affinity DataKi:  203nMpH: 7.5Assay Description:Kinetics were performed on a Cary 100 spectrophotometer (Varian) at 20 °C. Reaction velocities were measured by monitoring the oxidation of NAD(P)H t...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41Q89PubMed
LigandPNGBDBM7459(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)copy SMILEScopy InChI
Affinity DataKi:  7.05E+3nMAssay Description:Inhibition of Escherichia coli MG1655 enoyl-ACP reductase overexpressed in Escherichia coli M15 assessed as oxidation of NADH to NAD+ after 5 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MP547SPubMed
LigandPNGBDBM50067040(((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-hept...)copy SMILEScopy InChI
Affinity DataKi:  1.50E+4nMAssay Description:Inhibition of Escherichia coli MG1655 enoyl-ACP reductase overexpressed in Escherichia coli M15 assessed as oxidation of NADH to NAD+ after 5 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MP547SPubMed
LigandPNGBDBM50481111(CHEMBL566647)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibition of Escherichia coli FabI assessed as effect on NAD(P)H consumptionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0Q2BPubMed
LigandPNGBDBM50481110(CHEMBL586043)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Inhibition of Escherichia coli FabI assessed as effect on NAD(P)H consumptionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0Q2BPubMed
LigandPNGBDBM50481112(CHEMBL567711)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Inhibition of Escherichia coli FabI assessed as effect on NAD(P)H consumptionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0Q2BPubMed
LigandPNGBDBM50481108(CHEMBL566665)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Inhibition of Escherichia coli FabI assessed as effect on NAD(P)H consumptionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0Q2BPubMed
LigandPNGBDBM8726(5-chloro-2-(2,4-dichlorophenoxy)phenol | CHEMBL849...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of Escherichia coli FabI using 2-dodecenoyl-CoA as substrate at pH 8More data for this Ligand-Target Pair
LigandPNGBDBM50481114(CHEMBL566043)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of Escherichia coli FabI assessed as effect on NAD(P)H consumptionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0Q2BPubMed
LigandPNGBDBM50481103(CHEMBL583197)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of Escherichia coli FabIMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571FT3PubMed
LigandPNGBDBM50594238(CHEMBL5205550)copy SMILES
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56PRVPubMed
LigandPNGBDBM50594241(CHEMBL5196531)copy SMILES
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56PRVPubMed
LigandPNGBDBM50594240(CHEMBL5202156)copy SMILES
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56PRVPubMed
LigandPNGBDBM50594239(CHEMBL5200486)copy SMILES
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56PRVPubMed
LigandPNGBDBM50594237(CHEMBL5190373)copy SMILES
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56PRVPubMed
LigandPNGBDBM50594236(CHEMBL5190472)copy SMILES
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56PRVPubMed
LigandPNGBDBM50481102(CHEMBL567520)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of Escherichia coli FabIMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571FT3PubMed
LigandPNGBDBM50481105(CHEMBL567313)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of Escherichia coli FabIMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571FT3PubMed
LigandPNGBDBM50481097(CHEMBL565647)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of Escherichia coli FabIMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571FT3PubMed
LigandPNGBDBM50481100(CHEMBL576646)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of Escherichia coli FabIMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571FT3PubMed
LigandPNGBDBM50481106(CHEMBL571088)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of Escherichia coli FabI assessed as effect on NAD(P)H consumptionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0Q2BPubMed
LigandPNGBDBM50481109(CHEMBL566666)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibition of Escherichia coli FabI assessed as effect on NAD(P)H consumptionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0Q2BPubMed
TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Haemophilus influenzae)
GlaxoSmithKline

LigandPNGBDBM8735((2E)-N-[(1,2-dimethyl-1H-indol-3-yl)methyl]-N-meth...)copy SMILEScopy InChI
Affinity DataIC50: 25nMT: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB8018PubMed
LigandPNGBDBM50481094(CHEMBL567931)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of Escherichia coli FabIMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571FT3PubMed
LigandPNGBDBM50481101(CHEMBL567084)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of Escherichia coli FabIMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571FT3PubMed
LigandPNGBDBM50481096(CHEMBL567710)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:Inhibition of Escherichia coli FabIMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571FT3PubMed
LigandPNGBDBM8735((2E)-N-[(1,2-dimethyl-1H-indol-3-yl)methyl]-N-meth...)copy SMILEScopy InChI
Affinity DataIC50: 30nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB8018PubMed
LigandPNGBDBM50481098(CHEMBL567311)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of Escherichia coli FabIMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571FT3PubMed
LigandPNGBDBM50481099(CHEMBL570866)copy SMILEScopy InChI
Affinity DataIC50: 39nMAssay Description:Inhibition of Escherichia coli FabIMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571FT3PubMed
LigandPNGBDBM50481113(CHEMBL568359)copy SMILEScopy InChI
Affinity DataIC50: 55nMAssay Description:Inhibition of Escherichia coli FabI assessed as effect on NAD(P)H consumptionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0Q2BPubMed
LigandPNGBDBM50399407(CHEMBL2178284 | MUT056399)copy SMILEScopy InChI
Affinity DataIC50: 58nMMore data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM50399407(CHEMBL2178284 | MUT056399)copy SMILEScopy InChI
Affinity DataIC50: 58nMMore data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM8734((2E)-N-methyl-N-[(2-methyl-1H-indol-3-yl)methyl]-3...)copy SMILEScopy InChI
Affinity DataIC50: 60nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB8018PubMed
LigandPNGBDBM50481092(CHEMBL566655)copy SMILEScopy InChI
Affinity DataIC50: 64nMAssay Description:Inhibition of Escherichia coli FabIMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571FT3PubMed
LigandPNGBDBM8736((2E)-N-methyl-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naph...)copy SMILEScopy InChI
Affinity DataIC50: 70nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB8018PubMed
LigandPNGBDBM8733((2E)-N-methyl-N-[(1-methyl-1H-indol-3-yl)methyl]-3...)copy SMILEScopy InChI
Affinity DataIC50: 70nMpH: 6.5 T: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Haemophilus influenzae)
GlaxoSmithKline

LigandPNGBDBM8736((2E)-N-methyl-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naph...)copy SMILEScopy InChI
Affinity DataIC50: 70nMT: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB8018PubMed
LigandPNGBDBM50123848(CHEMBL3623422)copy SMILEScopy InChI
Affinity DataIC50: 110nMMore data for this Ligand-Target Pair
In DepthDetails
TargetEnoyl-[acyl-carrier-protein] reductase [NADH] FabI(Haemophilus influenzae)
GlaxoSmithKline

LigandPNGBDBM8734((2E)-N-methyl-N-[(2-methyl-1H-indol-3-yl)methyl]-3...)copy SMILEScopy InChI
Affinity DataIC50: 130nMT: 2°CAssay Description:Assays were carried out in half-area, 96-well microtiter plates. Compounds were evaluated in assay mixtures containing components specific for each e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB8018PubMed
LigandPNGBDBM50481093(CHEMBL566443)copy SMILEScopy InChI
Affinity DataIC50: 136nMAssay Description:Inhibition of Escherichia coli FabIMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571FT3PubMed
LigandPNGBDBM8732((2E)-N-methyl-N-[(1-methyl-1H-indol-2-yl)methyl]-3...)copy SMILEScopy InChI
Affinity DataIC50: 139nMAssay Description:Inhibition of Escherichia coli FabI assessed as effect on NAD(P)H consumptionMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0Q2BPubMed
LigandPNGBDBM50123812(CHEMBL3623402)copy SMILEScopy InChI
Affinity DataIC50: 140nMMore data for this Ligand-Target Pair
In DepthDetails
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