Found 109 Enz. Inhib. hit(s) with Target = 'Gamma-aminobutyric acid receptor subunit rho-1' TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 2.22E+3nMAssay Description:Antagonist activity at GABAC rho1 receptor (unknown origin)More data for this Ligand-Target Pair
3D Structure (crystal)TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 2.22E+3nMAssay Description:Antagonist activity at human recombinant GABAc rho-1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by t...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 5.40E+3nMAssay Description:Antagonist activity at human recombinant GABAc rho1 receptor expressed in Xenopus laevis oocytes at -60mV by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 5.50E+3nMAssay Description:Antagonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clam...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 6.60E+3nMAssay Description:Antagonist activity at human recombinant GABAA rho1 receptor expressed in Xenopus laevis assessed as inhibition of GABA-induced chloride current prod...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 9.60E+3nMAssay Description:Antagonist activity at human recombinant GABAA rho1 receptor expressed in Xenopus laevis assessed as inhibition of GABA-induced chloride current prod...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 9.76E+3nMAssay Description:Antagonist activity at human GABAC rho1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by two electrode ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 1.29E+4nMAssay Description:Antagonist activity at human recombinant GABAA rho1 receptor expressed in Xenopus laevis assessed as inhibition of GABA-induced chloride current prod...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 1.29E+4nMAssay Description:Antagonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clam...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 1.60E+4nMAssay Description:Antagonist activity at human recombinant GABAc rho1 receptor expressed in Xenopus laevis oocytes at -60mV by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 1.71E+4nMAssay Description:Antagonist activity at human recombinant GABAc rho1 receptor expressed in Xenopus laevis oocytes at -60mV by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 1.99E+4nMAssay Description:Antagonist activity at human recombinant GABAc rho-1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by t...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 2.97E+4nMAssay Description:Antagonist activity at human recombinant GABAc rho-1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by t...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 5.86E+4nMAssay Description:Antagonist activity at human GABAC rho1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current preincubated for ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 6.20E+4nMAssay Description:Antagonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clam...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 6.20E+4nMAssay Description:Antagonist activity at human recombinant GABAc rho-1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by t...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 7.65E+4nMAssay Description:Antagonist activity at human GABAC rho1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current preincubated for ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 8.15E+4nMAssay Description:Antagonist activity at human recombinant GABAA rho1 receptor expressed in Xenopus laevis assessed as inhibition of GABA-induced chloride current prod...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clam...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clam...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at recombinant human GABA-A rho-1 receptor transiently expressed in human tsA201 cells incubated for 30 mins and measured up to 9...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 1.03E+5nMAssay Description:Antagonist activity at human GABAC rho1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by two electrode ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 1.15E+5nMAssay Description:Antagonist activity at human recombinant GABAA rho1 receptor expressed in Xenopus laevis assessed as inhibition of GABA-induced chloride current prod...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 1.48E+5nMAssay Description:Antagonist activity at human GABAC rho1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by two electrode ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 1.53E+5nMAssay Description:Antagonist activity at human recombinant GABAA rho1 receptor expressed in Xenopus laevis assessed as inhibition of GABA-induced chloride current prod...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 1.93E+5nMAssay Description:Antagonist activity at human GABAC rho1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current preincubated for ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 2.81E+5nMAssay Description:Antagonist activity at human GABAC rho1 receptor expressed in Xenopus laevis oocytes assessed as inhibition of GABA-induced current by two electrode ...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 3.00E+5nMAssay Description:Antagonist activity at recombinant human GABA-A rho-1 receptor transiently expressed in human tsA201 cells incubated for 30 mins and measured up to 9...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 3.00E+5nMAssay Description:Antagonist activity at recombinant human GABA-A rho-1 receptor transiently expressed in human tsA201 cells incubated for 30 mins and measured up to 9...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 4.08E+5nMAssay Description:Antagonist activity at human recombinant GABAA rho1 receptor expressed in Xenopus laevis assessed as inhibition of GABA-induced chloride current prod...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 5.70E+5nMAssay Description:Antagonist activity at human recombinant GABAA rho1 receptor expressed in Xenopus laevis assessed as inhibition of GABA-induced chloride current prod...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 8.00E+5nMAssay Description:Antagonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clam...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataIC50: 8.90E+5nMAssay Description:Antagonist activity at human recombinant GABAc rho1 receptor expressed in Xenopus laevis oocytes at -60mV by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataEC50: 440nMAssay Description:Partial agonist activity against human rho-1 subunit GABA-C receptor expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataEC50: 6.80E+4nMAssay Description:Full agonist activity against human rho-1 subunit GABA-C receptor expressed in Xenopus oocytesMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataEC50: 270nMAssay Description:Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataEC50: 700nMAssay Description:Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataEC50: 3.90E+4nMAssay Description:Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataEC50: 2.30E+3nMAssay Description:Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataEC50: 8.10E+3nMAssay Description:Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataEC50: 269nMAssay Description:Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataEC50: 692nMAssay Description:Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataEC50: 3.89E+4nMAssay Description:Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataEC50: <1.00E+6nMAssay Description:Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataEC50: <1.00E+6nMAssay Description:Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit rho-1(Homo sapiens (Human))
The University of Sydney
Curated by ChEMBL
The University of Sydney
Curated by ChEMBL
Affinity DataEC50: <1.00E+6nMAssay Description:Agonist activity at human GABAA rho1 expressed in tsA-201cells by FLIPR membrane potential blue assayMore data for this Ligand-Target Pair
