Compile Data Set for Download or QSAR
Found 170 Enz. Inhib. hit(s) with Target = 'High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A'
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50150119(CHEMBL3769414)copy SMILEScopy InChI
Affinity DataKi:  3.00E+3nMAssay Description:Inhibition of recombinant full lenght human PDE8A using fluorescent labeled cAMP as substrate after 15 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X068W7PubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50150264(CHEMBL3769817)copy SMILEScopy InChI
Affinity DataKi:  8.20E+3nMAssay Description:Inhibition of recombinant full lenght human PDE8A using fluorescent labeled cAMP as substrate after 15 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X068W7PubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50362033(CHEMBL1939912)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]cAMP from PDE8A1 by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862GWCPubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50362047(CHEMBL1940057)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]cAMP from PDE8A1 by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862GWCPubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50362046(CHEMBL1940056)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]cAMP from PDE8A1 by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862GWCPubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50362048(CHEMBL1940058)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]cAMP from PDE8A1 by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862GWCPubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50362035(CHEMBL1939914)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]cAMP from PDE8A1 by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862GWCPubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50362036(CHEMBL1939915)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]cAMP from PDE8A1 by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862GWCPubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50362043(CHEMBL1940053)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]cAMP from PDE8A1 by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862GWCPubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50150171(CHEMBL3770470)copy SMILEScopy InChI
Affinity DataKi:  3.30E+4nMAssay Description:Inhibition of recombinant full lenght human PDE8A using fluorescent labeled cAMP as substrate after 15 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X068W7PubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50150239(CHEMBL3769461)copy SMILEScopy InChI
Affinity DataKi:  5.40E+4nMAssay Description:Inhibition of recombinant full lenght human PDE8A using fluorescent labeled cAMP as substrate after 15 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X068W7PubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50150238(CHEMBL3770107)copy SMILEScopy InChI
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of recombinant full lenght human PDE8A using fluorescent labeled cAMP as substrate after 15 mins by IMAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X068W7PubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50594973(CHEMBL5169811)copy SMILES
Affinity DataIC50: 0.700nMAssay Description:Antagonist activity at human EP1 receptor expressed in CHO cells receptor by NFTA reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50594973(CHEMBL5169811)copy SMILES
Affinity DataIC50: 0.700nMAssay Description:Antagonistic affinity tested against isolated Rat Spleen Alpha-1B adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50344018(CHEMBL1779984 | trans-(3R,5R)-5-ethyl-1-((5-methyl...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20002F8PubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50344017(1-((5-methyl-2-phenyloxazol-4-yl)methyl)-N-((6-met...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20002F8PubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50344016(2-((5-methyl-2-phenyloxazol-4-yl)methyl)-N-((6-met...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20002F8PubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50390334(CHEMBL2070735)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67J0XPubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50555231(CHEMBL4762103)copy SMILES
Affinity DataIC50: 10nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP substrate incubated for 15 mins by liq...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM135584(US8846654, 294)copy SMILEScopy InChI
Affinity DataIC50: 15nMpH: 7.5Assay Description:By using for PDE8 an enzymatic assay equivalent to that described for PDE7. PDE7 Enzymatic Assay: The assay is carried out in 1.5 ml Eppendorf tube...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21V5CPZUS Patent
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50555230(CHEMBL4753446)copy SMILES
Affinity DataIC50: 26nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP substrate incubated for 15 mins by liq...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50555224(CHEMBL4790482)copy SMILES
Affinity DataIC50: 46nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP substrate incubated for 15 mins by liq...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ3BV5PubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50555221(CHEMBL4800434)copy SMILES
Affinity DataIC50: 130nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP substrate incubated for 15 mins by liq...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ3BV5PubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM135577(US8846654, 11)copy SMILEScopy InChI
Affinity DataIC50: 140nMpH: 7.5Assay Description:By using for PDE8 an enzymatic assay equivalent to that described for PDE7. PDE7 Enzymatic Assay: The assay is carried out in 1.5 ml Eppendorf tube...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21V5CPZUS Patent
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50555225(CHEMBL4789101)copy SMILES
Affinity DataIC50: 220nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP substrate incubated for 15 mins by liq...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ3BV5PubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50555220(CHEMBL4778928)copy SMILES
Affinity DataIC50: 240nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP substrate incubated for 15 mins by liq...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ3BV5PubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50555222(CHEMBL4798107)copy SMILES
Affinity DataIC50: 250nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP substrate incubated for 15 mins by liq...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ3BV5PubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50555223(CHEMBL4745958)copy SMILES
Affinity DataIC50: 250nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP substrate incubated for 15 mins by liq...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ3BV5PubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50407428(CHEMBL5288859)copy SMILEScopy InChI
Affinity DataIC50: 280nMAssay Description:Antagonistic affinity tested against isolated Rat Thoracic Aorta Alpha-1D adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50555229(CHEMBL4757863)copy SMILES
Affinity DataIC50: 360nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP substrate incubated for 15 mins by liq...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM135583(US8846654, 251)copy SMILEScopy InChI
Affinity DataIC50: 390nMpH: 7.5Assay Description:By using for PDE8 an enzymatic assay equivalent to that described for PDE7. PDE7 Enzymatic Assay: The assay is carried out in 1.5 ml Eppendorf tube...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21V5CPZUS Patent
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50555227(CHEMBL4747327)copy SMILES
Affinity DataIC50: 410nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP substrate incubated for 15 mins by liq...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ3BV5PubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50357870(CHEMBL1916130)copy SMILEScopy InChI
Affinity DataIC50: 500nMAssay Description:Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125T2BPubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM23620(2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin...)copy SMILEScopy InChI
Affinity DataIC50: 500nMpH: 7.5 T: 2°CAssay Description:Enzymatic activities were assayed using [3H] cAMP and [3H]cGMP as substrate.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K9364DPubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50555228(CHEMBL4750412)copy SMILES
Affinity DataIC50: 660nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP substrate incubated for 15 mins by liq...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ3BV5PubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50575152(CHEMBL4877549)copy SMILES
Affinity DataIC50: 710nMAssay Description:Inhibition of PDE8A1 (480-828) (unknown origin) expressed in Escherichia coli BL21 assessed as using [3H]-cAMP as substrate measured for 15 mins by l...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5RM9PubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50555226(CHEMBL4786234)copy SMILES
Affinity DataIC50: 920nMAssay Description:Inhibition of PDE8A1 (480 to 820 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cAMP substrate incubated for 15 mins by liq...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ3BV5PubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50319163(8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6D3NPubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50357871(CHEMBL1916131)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125T2BPubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50357826(CHEMBL1915892)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125T2BPubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50356427(CHEMBL1911559)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant PDE8AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD1Z91PubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50259148((-)2-({(trans)-2-[(3-isopropyl-7-oxo-6,7-dihydro-1...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PDE8aMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RB74GGPubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50357872(CHEMBL1916132)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125T2BPubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50357825(CHEMBL1915891)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human PDE8A using [3H]cAMP after 1 hr by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125T2BPubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50357234(CHEMBL1916475)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67HB0PubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50308557(3-(4-(2-hydroxyethyl)piperazin-1-yl)-1-(2-propoxye...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM4CCKPubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50296256(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Intra-Cellular Therapies, Inc.

Curated by ChEMBL
LigandPNGBDBM50300953(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of PDE8AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
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