Compile Data Set for Download or QSAR
Found 238 Enz. Inhib. hit(s) with Target = 'Leukotriene C4 synthase'
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM223288((1S,2S)-2-[(5-{(2-Fluoro-2-methylpropyl)[2-fluoro-...)copy SMILEScopy InChI
Affinity DataIC50: 0.248nMpH: 7.5Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester. In order to obtain IC50-v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W66JN5US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM223288((1S,2S)-2-[(5-{(2-Fluoro-2-methylpropyl)[2-fluoro-...)copy SMILEScopy InChI
Affinity DataIC50: 0.248nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1NPGUS Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM223288((1S,2S)-2-[(5-{(2-Fluoro-2-methylpropyl)[2-fluoro-...)copy SMILEScopy InChI
Affinity DataIC50: 0.25nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519568(CHEMBL4549822)copy SMILEScopy InChI
Affinity DataIC50: 0.280nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM223287((1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-flu...)copy SMILEScopy InChI
Affinity DataIC50: 0.280nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM223287((1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-flu...)copy SMILEScopy InChI
Affinity DataIC50: 0.289nMpH: 7.5Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester. In order to obtain IC50-v...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W66JN5US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM223287((1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-flu...)copy SMILEScopy InChI
Affinity DataIC50: 0.289nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1NPGUS Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519570(CHEMBL4567083)copy SMILEScopy InChI
Affinity DataIC50: 0.360nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519585(CHEMBL4464773)copy SMILEScopy InChI
Affinity DataIC50: 0.381nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM223289((1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(propy...)copy SMILEScopy InChI
Affinity DataIC50: 0.483nMpH: 7.5Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester. In order to obtain IC50-v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W66JN5US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM310035((1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(propy...)copy SMILEScopy InChI
Affinity DataIC50: 0.483nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1NPGUS Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519591(CHEMBL4562583)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519574(CHEMBL4563433)copy SMILEScopy InChI
Affinity DataIC50: 0.626nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519588(CHEMBL4584584)copy SMILEScopy InChI
Affinity DataIC50: 0.630nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM223290((1S,2S)-2-[(5-{[2-Fluoro-5-(trifluoromethyl)phenyl...)copy SMILEScopy InChI
Affinity DataIC50: 0.658nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1NPGUS Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM223290((1S,2S)-2-[(5-{[2-Fluoro-5-(trifluoromethyl)phenyl...)copy SMILEScopy InChI
Affinity DataIC50: 0.658nMpH: 7.5Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester. In order to obtain IC50-v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W66JN5US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM223290((1S,2S)-2-[(5-{[2-Fluoro-5-(trifluoromethyl)phenyl...)copy SMILEScopy InChI
Affinity DataIC50: 0.660nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519580(CHEMBL4574439)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519565(CHEMBL4441362)copy SMILEScopy InChI
Affinity DataIC50: 0.758nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519567(CHEMBL4476024)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519571(CHEMBL4454609)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519595(CHEMBL4545014)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519569(CHEMBL4545950)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519585(CHEMBL4464773)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519582(CHEMBL4525972)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519570(CHEMBL4567083)copy SMILEScopy InChI
Affinity DataIC50: 3.5nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519587(CHEMBL4467942)copy SMILEScopy InChI
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519568(CHEMBL4549822)copy SMILEScopy InChI
Affinity DataIC50: 4.10nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519590(CHEMBL4574370)copy SMILEScopy InChI
Affinity DataIC50: 4.70nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519592(CHEMBL4442047)copy SMILEScopy InChI
Affinity DataIC50: 4.90nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519579(CHEMBL4576647)copy SMILEScopy InChI
Affinity DataIC50: 5.30nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519575(CHEMBL4567339)copy SMILEScopy InChI
Affinity DataIC50: 6.40nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM223290((1S,2S)-2-[(5-{[2-Fluoro-5-(trifluoromethyl)phenyl...)copy SMILEScopy InChI
Affinity DataIC50: 6.80nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519574(CHEMBL4563433)copy SMILEScopy InChI
Affinity DataIC50: 7.10nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM223288((1S,2S)-2-[(5-{(2-Fluoro-2-methylpropyl)[2-fluoro-...)copy SMILEScopy InChI
Affinity DataIC50: 7.80nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519586(CHEMBL4439499)copy SMILEScopy InChI
Affinity DataIC50: 7.90nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519580(CHEMBL4574439)copy SMILEScopy InChI
Affinity DataIC50: 8.5nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519577(CHEMBL4439148)copy SMILEScopy InChI
Affinity DataIC50: 8.70nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM223261(2-(5-((Cyclopropylmethyl)(1,2-dihydroacenaphthylen...)copy SMILEScopy InChI
Affinity DataIC50: 9nMpH: 7.8Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 is converted to LTC4. Recombinant human LTC4 synthase is expressed in Pic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W66JN5US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM223261(2-(5-((Cyclopropylmethyl)(1,2-dihydroacenaphthylen...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1NPGUS Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519571(CHEMBL4454609)copy SMILEScopy InChI
Affinity DataIC50: 9.40nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM223287((1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-flu...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519578(CHEMBL4445815)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519589(CHEMBL4531985)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519566(CHEMBL4565208)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519569(CHEMBL4545950)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519591(CHEMBL4562583)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519573(CHEMBL4456770)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519567(CHEMBL4476024)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of LTC4S in zymosan-stimulated human PBMC assessed as inhibition of LTC4 production preincubated for 45 mins followed by zymosan stimulati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM223281(2-(5-((Cyclopropylmethyl)(naphthalen-1-yl)amino)-4...)copy SMILEScopy InChI
Affinity DataIC50: 17nMpH: 7.8Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 is converted to LTC4. Recombinant human LTC4 synthase is expressed in Pic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W66JN5US Patent
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