Compile Data Set for Download or QSAR
Found 228 Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase 9'
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM350085(3-[3-[4-[dideuterio(methylamino)methyl]phenyl]isox...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:ATP competitive inhibition of human MLK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BZ69C9PubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM50224883(7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...)copy SMILEScopy InChI
Affinity DataKi: >1.67E+3nMAssay Description:Inhibition of MLK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X067WTPubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI
Affinity DataIC50: 0.544nMAssay Description:Inhibition of human MLK1 using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5KB8PubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human MLK1 using casein as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W380MTPubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of MLK1 (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD22MPPubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM50458548(CHEMBL4218417)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant GST-tagged human MLK1 KD (1 to 500 residues) expressed in baculovirus using myelin basic protein as substrate preincubated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G163G3PubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM50108296(CHEMBL289772 | Indolocarbazole analogue)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of Mixed lineage kinase 1 (MLK1)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B94PubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM50108295(CHEMBL288817 | Indolocarbazole analogue)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of Mixed lineage kinase 1 (MLK1)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B94PubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM50441567(CHEMBL2436978 | US10485800, Example 181)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of MLK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM50108293(CHEMBL277817 | Indolocarbazole analogue)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of Mixed lineage kinase 1 (MLK1)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B94PubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM6760((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)copy SMILEScopy InChI
Affinity DataIC50: 22nMpH: 7.2 T: 2°CAssay Description:The MLK1, MLK2, and MLK3 assays were performed using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. IC50 values were calculate...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2MJXPubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM14186(12,13-Dihydro-6H,14H-naphthyl[3,4-a]pyrrolo[3,4-c]...)copy SMILEScopy InChI
Affinity DataIC50: 22nMpH: 7.2 T: 2°CAssay Description:The MLK1, MLK2, and MLK3 assays were performed using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. IC50 values were calculate...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2MJXPubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM24949(3-(2-hydroxyethyl)-20-(propan-2-yloxy)-3,13-diazah...)copy SMILEScopy InChI
Affinity DataIC50: 26nMpH: 7.2 T: 2°CAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8K09PubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM50108299(CHEMBL288229 | Indolocarbazole analogue)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibition of Mixed lineage kinase 1 (MLK1)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B94PubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM24942(CEP-1347 | CHEMBL290352 | methyl (15S,16R,18R)-10,...)copy SMILEScopy InChI
Affinity DataIC50: 38nMpH: 7.2 T: 2°CAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8K09PubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM24942(CEP-1347 | CHEMBL290352 | methyl (15S,16R,18R)-10,...)copy SMILEScopy InChI
Affinity DataIC50: 38nMAssay Description:Inhibition of recombinant GST-tagged human MLK1 KD (1 to 500 residues) expressed in baculovirus using myelin basic protein as substrate preincubated ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G163G3PubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM24942(CEP-1347 | CHEMBL290352 | methyl (15S,16R,18R)-10,...)copy SMILEScopy InChI
Affinity DataIC50: 38nMAssay Description:Inhibition of Mixed lineage kinase 1 (MLK1)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B94PubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM50108291(CHEMBL36891 | Indolocarbazole analogue)copy SMILEScopy InChI
Affinity DataIC50: 43nMAssay Description:Inhibition of Mixed lineage kinase 1 (MLK1)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B94PubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM50392791(CHEMBL2151321 | US8486966, 1)copy SMILEScopy InChI
Affinity DataIC50: 44.3nMAssay Description:Inhibition of MLK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GH9K2GPubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM50108297(CHEMBL288816 | Indolocarbazole analogue)copy SMILEScopy InChI
Affinity DataIC50: 45nMAssay Description:Inhibition of Mixed lineage kinase 1 (MLK1)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B94PubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM14174(12,13-Dihydro-5H,6H,14H-naphthy[3,4-a]pyrrolo[3,4-...)copy SMILEScopy InChI
Affinity DataIC50: 46nMpH: 7.2 T: 2°CAssay Description:The MLK1, MLK2, and MLK3 assays were performed using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. IC50 values were calculate...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2MJXPubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM24952(20-(cyclopentyloxy)-3-(2-hydroxyethyl)-3,13-diazah...)copy SMILEScopy InChI
Affinity DataIC50: 49nMpH: 7.2 T: 2°CAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8K09PubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM50095952(CHEMBL3593777)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:Inhibition of MLK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DZ0B21PubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM50466038(CHEMBL4281823)copy SMILEScopy InChI
Affinity DataIC50: 52nMAssay Description:Inhibition of recombinant human MLK1 (134 to 414 residues) using casein as substrate after 40 mins in presence of [gamma-33P]-ATP by scintillation co...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2377CDJPubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM50400047(BIIB-057 | CHEMBL2177736 | US9579320, Example 87)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Employing the Milipore panel of purified kinases EXAMPLE 87 (IC50=1 nM) inhibited 98% of purified Syk kinase activity at 50 nM. IC50 values were dete...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CF9NV0US Patent
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM24944(20-(propan-2-yloxy)-3,13-diazahexacyclo[14.8.0.0^{...)copy SMILEScopy InChI
Affinity DataIC50: 66nMpH: 7.2 T: 2°CAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8K09PubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM14188(3-thia-13,23-diazahexacyclo[14.7.0.0^{2,10}.0^{4,9...)copy SMILEScopy InChI
Affinity DataIC50: 68nMpH: 7.2 T: 2°CAssay Description:The MLK1, MLK2, and MLK3 assays were performed using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. IC50 values were calculate...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2MJXPubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM50059190(CHEMBL3393333)copy SMILEScopy InChI
Affinity DataIC50: 68nMAssay Description:Inhibition of MLK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J6DJ5PubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM14177(3,13-diazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,...)copy SMILEScopy InChI
Affinity DataIC50: 69nMpH: 7.2 T: 2°CAssay Description:The MLK1, MLK2, and MLK3 assays were performed using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. IC50 values were calculate...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2MJXPubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM50108292(CHEMBL37529 | Indolocarbazole analogue)copy SMILEScopy InChI
Affinity DataIC50: 90nMAssay Description:Inhibition of Mixed lineage kinase 1 (MLK1)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B94PubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM24948(3-(3-hydroxypropyl)-20-methoxy-3,13-diazahexacyclo...)copy SMILEScopy InChI
Affinity DataIC50: 101nMpH: 7.2 T: 2°CAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8K09PubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM24947(3-(2-hydroxyethyl)-20-methoxy-3,13-diazahexacyclo[...)copy SMILEScopy InChI
Affinity DataIC50: 103nMpH: 7.2 T: 2°CAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8K09PubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM14179(3-thia-13,23-diazahexacyclo[14.7.0.0^{2,10}.0^{4,9...)copy SMILEScopy InChI
Affinity DataIC50: 111nMpH: 7.2 T: 2°CAssay Description:The MLK1, MLK2, and MLK3 assays were performed using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. IC50 values were calculate...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2MJXPubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM2581(3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^...)copy SMILEScopy InChI
Affinity DataIC50: 138nMpH: 7.2 T: 2°CAssay Description:The MLK1, MLK2, and MLK3 assays were performed using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. IC50 values were calculate...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2MJXPubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM50425862(CHEMBL2312654)copy SMILEScopy InChI
Affinity DataIC50: 160nMAssay Description:Inhibition of MAP3K9 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XW4M38PubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM50108294(CHEMBL288818 | Indolocarbazole analogue)copy SMILEScopy InChI
Affinity DataIC50: 162nMAssay Description:Inhibition of Mixed lineage kinase 1 (MLK1)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B94PubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM14173(3,13-diazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,...)copy SMILEScopy InChI
Affinity DataIC50: 167nMpH: 7.2 T: 2°CAssay Description:The MLK1, MLK2, and MLK3 assays were performed using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. IC50 values were calculate...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2MJXPubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM24943(20-methoxy-3,13-diazahexacyclo[14.8.0.0^{2,10}.0^{...)copy SMILEScopy InChI
Affinity DataIC50: 188nMpH: 7.2 T: 2°CAssay Description:The MLK kinase assays were performed by using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. The inhibition curves were genera...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8K09PubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM50358204(CHEMBL1922094)copy SMILEScopy InChI
Affinity DataIC50: 232nMAssay Description:Inhibition of Mlk1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SF2WMTPubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM50553207(CHEMBL4786783)copy SMILES
Affinity DataIC50: 270nMAssay Description:Inhibition of human MLK1 by kinase-profiling analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P272RVPubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM14187(3,13-diazahexacyclo[14.8.0.0^{2,10}.0^{4,9}.0^{11,...)copy SMILEScopy InChI
Affinity DataIC50: 300nMpH: 7.2 T: 2°CAssay Description:The MLK1, MLK2, and MLK3 assays were performed using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. IC50 values were calculate...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2MJXPubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM14185(3,13-diazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,...)copy SMILEScopy InChI
Affinity DataIC50: 300nMpH: 7.2 T: 2°CAssay Description:The MLK1, MLK2, and MLK3 assays were performed using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. IC50 values were calculate...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2MJXPubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM50108298(CHEMBL29709 | Indolocarbazole analogue)copy SMILEScopy InChI
Affinity DataIC50: 303nMAssay Description:Inhibition of Mixed lineage kinase 1 (MLK1)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B94PubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM14176(3-oxa-13,23-diazahexacyclo[14.7.0.0^{2,10}.0^{4,9}...)copy SMILEScopy InChI
Affinity DataIC50: 308nMpH: 7.2 T: 2°CAssay Description:The MLK1, MLK2, and MLK3 assays were performed using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. IC50 values were calculate...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2MJXPubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM50108300(CHEMBL38338 | Indolocarbazole analogue)copy SMILEScopy InChI
Affinity DataIC50: 360nMAssay Description:Inhibition of Mixed lineage kinase 1 (MLK1)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571B94PubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM50430289(CHEMBL2333445)copy SMILEScopy InChI
Affinity DataIC50: 370nMAssay Description:Inhibition of MLK1 (unknown origin) using [gamma-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KP83HSPubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM50402409(CHEMBL2208034)copy SMILEScopy InChI
Affinity DataIC50: 370nMAssay Description:Inhibition of MLK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ59ZNPubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM14183(3-thia-13-azahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{...)copy SMILEScopy InChI
Affinity DataIC50: 482nMpH: 7.2 T: 2°CAssay Description:The MLK1, MLK2, and MLK3 assays were performed using the Millipore multiscreen trichloroacetic acid (TCA) in-plate format. IC50 values were calculate...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HT2MJXPubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM50312613(2-(2-(2-Aminopyrimidin-5-yl)-4-morpholinothieno[3,...)copy SMILEScopy InChI
Affinity DataIC50: 591nMAssay Description:Inhibition of MLK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GXTPubMed
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL
LigandPNGBDBM50509365(CHEMBL4564337)copy SMILEScopy InChI
Affinity DataIC50: 600nMAssay Description:Inhibition of MLK1 (unknown origin) by [33P]-ATP filter binding kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3B4RPubMed
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