Compile Data Set for Download or QSAR
Found 21 Enz. Inhib. hit(s) with Target = 'Neuronal acetylcholine receptor; alpha2/beta4'
TargetNeuronal acetylcholine receptor; alpha2/beta4(Homo sapiens (Human))
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)copy SMILEScopy InChI
Affinity DataKi:  0.0910nMAssay Description:Agonistic potency against nicotinic acetylcholine receptor alpha3-beta4More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor; alpha2/beta4(Homo sapiens (Human))
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50137787(6-(6-Chloro-pyridin-3-yl)-8-aza-bicyclo[3.2.1]octa...)copy SMILEScopy InChI
Affinity DataKi:  31nMAssay Description:In vitro ability to displace [3H]-(-)-cytisine binding to whole rat brain membranes at Nicotinic acetylcholine receptor alpha4-beta2More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8ZD0PubMed
TargetNeuronal acetylcholine receptor; alpha2/beta4(Homo sapiens (Human))
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)copy SMILEScopy InChI
Affinity DataKi:  70nMAssay Description:Displacement of [3H]epibatidine from alpha2beta4 nAChR after 4 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25M66WSPubMed
TargetNeuronal acetylcholine receptor; alpha2/beta4(Homo sapiens (Human))
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)copy SMILEScopy InChI
Affinity DataKi:  103nMAssay Description:Binding affinity against nicotinic acetylcholine receptor alpha2-beta4 using [3H]epibatidine as radioligand expressed in HEK293 cells or tsA cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8ZD0PubMed
TargetNeuronal acetylcholine receptor; alpha2/beta4(Homo sapiens (Human))
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50400739(CHEMBL2203550)copy SMILEScopy InChI
Affinity DataKi:  1.82E+3nMAssay Description:Displacement of [3H]epibatidine from alpha2beta4 nAChR after 4 hrs by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25M66WSPubMed
TargetNeuronal acetylcholine receptor; alpha2/beta4(Homo sapiens (Human))
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50170586((3S)-3-{[(2S)-1-[(2S)-2-[(2S,3R)-2-[(2S)-2-[(2S)-2...)copy SMILEScopy InChI
Affinity DataIC50: 0.75nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha2-beta4; Range is 0.3-1.5 nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0G79PubMed
TargetNeuronal acetylcholine receptor; alpha2/beta4(Homo sapiens (Human))
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50170592(CHEMBL411146)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha2-beta4; Range is 0.3-1.5 nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0G79PubMed
TargetNeuronal acetylcholine receptor; alpha2/beta4(Homo sapiens (Human))
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50170594((16R)-9,33-dihydroxy-10,25-dimethoxy-15,15,30-trim...)copy SMILEScopy InChI
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha2-beta4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0G79PubMed
TargetNeuronal acetylcholine receptor; alpha2/beta4(Homo sapiens (Human))
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50170594((16R)-9,33-dihydroxy-10,25-dimethoxy-15,15,30-trim...)copy SMILEScopy InChI
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha2-beta4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0G79PubMed
TargetNeuronal acetylcholine receptor; alpha2/beta4(Homo sapiens (Human))
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50369323(MECAMYLAMINE)copy SMILEScopy InChI
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha2-beta4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0G79PubMed
TargetNeuronal acetylcholine receptor; alpha2/beta4(Homo sapiens (Human))
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50061562((12R,13aR)-12-Methoxy-1,4,5,6,9,11,12,13-octahydro...)copy SMILEScopy InChI
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha2-beta4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0G79PubMed
TargetNeuronal acetylcholine receptor; alpha2/beta4(Homo sapiens (Human))
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50061562((12R,13aR)-12-Methoxy-1,4,5,6,9,11,12,13-octahydro...)copy SMILEScopy InChI
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha2-beta4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0G79PubMed
TargetNeuronal acetylcholine receptor; alpha2/beta4(Homo sapiens (Human))
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50581248(CHEMBL5090753)copy SMILES
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human alpha2beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response by two-ele...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542SG3PubMed
TargetNeuronal acetylcholine receptor; alpha2/beta4(Homo sapiens (Human))
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50606633(CHEMBL5219936)copy SMILES
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3Q8VPubMed
TargetNeuronal acetylcholine receptor; alpha2/beta4(Homo sapiens (Human))
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50581246(CHEMBL5080428)copy SMILES
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human alpha2beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response by two-ele...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542SG3PubMed
TargetNeuronal acetylcholine receptor; alpha2/beta4(Homo sapiens (Human))
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50567435(CHEMBL4872191)copy SMILES
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human alpha2beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response by two-ele...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN77P3PubMed
TargetNeuronal acetylcholine receptor; alpha2/beta4(Homo sapiens (Human))
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50567433(CHEMBL4869892)copy SMILES
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human alpha2beta4 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response by two-ele...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CN77P3PubMed
TargetNeuronal acetylcholine receptor; alpha2/beta4(Homo sapiens (Human))
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50369323(MECAMYLAMINE)copy SMILEScopy InChI
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha2-beta4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0G79PubMed
TargetNeuronal acetylcholine receptor; alpha2/beta4(Homo sapiens (Human))
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50071366(7-Methoxy-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-h...)copy SMILEScopy InChI
Affinity DataEC50:  8.70E+4nMAssay Description:Compound was evaluated for agonist activity against activated human recombinant Nicotinic acetylcholine receptor alpha2-beta4 in Xenopus OocytesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2V9877JPubMed
TargetNeuronal acetylcholine receptor; alpha2/beta4(Homo sapiens (Human))
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50052593(3-Ethynyl-5-((S)-1-methyl-azetidin-2-yl)-pyridine ...)copy SMILEScopy InChI
Affinity DataEC50:  3.20E+3nMAssay Description:Effective concentration against Nicotinic acetylcholine receptor alpha2-beta4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0G79PubMed
TargetNeuronal acetylcholine receptor; alpha2/beta4(Homo sapiens (Human))
University of Wollongong

Curated by ChEMBL
LigandPNGBDBM50170598(5'-phenyl-3'H-4-azaspiro[bicyclo[2.2.2]octane-2,2'...)copy SMILEScopy InChI
Affinity DataEC50: >1.00E+5nMAssay Description:Effective concentration against Nicotinic acetylcholine receptor alpha2-beta4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0G79PubMed