Compile Data Set for Download or QSAR
Found 31 Enz. Inhib. hit(s) with Target = 'Non-receptor tyrosine-protein kinase TYK2 [5-1181]'
LigandPNGBDBM50530383(CHEMBL4530719)copy SMILEScopy InChI
Affinity DataIC50: 83nMAssay Description:Inhibition of TYK2 JH2 domain in mouse whole blood assessed as inhibition of IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95DMQPubMed
LigandPNGBDBM50530383(CHEMBL4530719)copy SMILEScopy InChI
Affinity DataIC50: 83nMAssay Description:Inhibition of TYK2 JH2 domain in mouse whole blood assessed as inhibition of IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95DMQPubMed
LigandPNGBDBM50519520(CHEMBL4571117)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of TYK2 in mouse whole blood assessed as decrease in IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by stimulation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50507816(Bms-986165 | Deucravacitinib)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of TYK2 in mouse whole blood assessed as decrease in IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by stimulation ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50519523(CHEMBL4440718)copy SMILEScopy InChI
Affinity DataIC50: 120nMAssay Description:Inhibition of TYK2 JH2 domain in mouse whole blood assessed as inhibition of IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95DMQPubMed
LigandPNGBDBM50519523(CHEMBL4440718)copy SMILEScopy InChI
Affinity DataIC50: 120nMAssay Description:Inhibition of TYK2 JH2 domain in mouse whole blood assessed as inhibition of IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95DMQPubMed
LigandPNGBDBM50519518(CHEMBL4557190)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Inhibition of TYK2 in mouse whole blood assessed as decrease in IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by stimulation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50446982(CHEMBL3116050)copy SMILEScopy InChI
Affinity DataIC50: 240nMAssay Description:Inhibition of Tyk2 in mouse BA/F3 cells expressing TEL-Tyk2 assessed as inhibition of STAT5 phosphorylation by Western blotting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CR5VTMPubMed
LigandPNGBDBM50519537(CHEMBL4469750)copy SMILEScopy InChI
Affinity DataIC50: 260nMAssay Description:Inhibition of TYK2 in mouse whole blood assessed as decrease in IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by stimulation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50519542(CHEMBL4572855)copy SMILEScopy InChI
Affinity DataIC50: 310nMAssay Description:Inhibition of TYK2 in mouse whole blood assessed as decrease in IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by stimulation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50519543(CHEMBL4457060)copy SMILEScopy InChI
Affinity DataIC50: 320nMAssay Description:Inhibition of TYK2 in mouse whole blood assessed as decrease in IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by stimulation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50519539(CHEMBL4476261)copy SMILEScopy InChI
Affinity DataIC50: 330nMAssay Description:Inhibition of TYK2 in mouse whole blood assessed as decrease in IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by stimulation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50530396(CHEMBL4544320)copy SMILEScopy InChI
Affinity DataIC50: 340nMAssay Description:Inhibition of TYK2 JH2 domain in mouse whole blood assessed as inhibition of IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95DMQPubMed
LigandPNGBDBM50530396(CHEMBL4544320)copy SMILEScopy InChI
Affinity DataIC50: 340nMAssay Description:Inhibition of TYK2 JH2 domain in mouse whole blood assessed as inhibition of IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95DMQPubMed
LigandPNGBDBM50530395(CHEMBL4444178)copy SMILEScopy InChI
Affinity DataIC50: 340nMAssay Description:Inhibition of TYK2 JH2 domain in mouse whole blood assessed as inhibition of IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95DMQPubMed
LigandPNGBDBM50530395(CHEMBL4444178)copy SMILEScopy InChI
Affinity DataIC50: 340nMAssay Description:Inhibition of TYK2 JH2 domain in mouse whole blood assessed as inhibition of IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95DMQPubMed
LigandPNGBDBM50530403(CHEMBL4583185)copy SMILEScopy InChI
Affinity DataIC50: 380nMAssay Description:Inhibition of TYK2 JH2 domain in mouse whole blood assessed as inhibition of IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95DMQPubMed
LigandPNGBDBM50530403(CHEMBL4583185)copy SMILEScopy InChI
Affinity DataIC50: 380nMAssay Description:Inhibition of TYK2 JH2 domain in mouse whole blood assessed as inhibition of IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95DMQPubMed
LigandPNGBDBM50519535(CHEMBL4565054)copy SMILEScopy InChI
Affinity DataIC50: 380nMAssay Description:Inhibition of TYK2 in mouse whole blood assessed as decrease in IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by stimulation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50519519(CHEMBL4566158)copy SMILEScopy InChI
Affinity DataIC50: 430nMAssay Description:Inhibition of TYK2 in mouse whole blood assessed as decrease in IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by stimulation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50530398(CHEMBL4526283)copy SMILEScopy InChI
Affinity DataIC50: 450nMAssay Description:Inhibition of TYK2 JH2 domain in mouse whole blood assessed as inhibition of IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95DMQPubMed
LigandPNGBDBM50530398(CHEMBL4526283)copy SMILEScopy InChI
Affinity DataIC50: 450nMAssay Description:Inhibition of TYK2 JH2 domain in mouse whole blood assessed as inhibition of IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95DMQPubMed
LigandPNGBDBM50565986(CHEMBL4789639)copy SMILES
Affinity DataIC50: 481nMAssay Description:Inhibition of TYK2 in mouse whole blood assessed as decrease in IFNalpha-induced STAT5 phosphorylationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XW4PJXPubMed
LigandPNGBDBM50519548(CHEMBL4543984)copy SMILEScopy InChI
Affinity DataIC50: 522nMAssay Description:Inhibition of TYK2 in mouse whole blood assessed as decrease in IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by stimulation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50519532(CHEMBL4443834)copy SMILEScopy InChI
Affinity DataIC50: 570nMAssay Description:Inhibition of TYK2 in mouse whole blood assessed as decrease in IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by stimulation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50530391(CHEMBL4444169)copy SMILEScopy InChI
Affinity DataIC50: 600nMAssay Description:Inhibition of TYK2 JH2 domain in mouse whole blood assessed as inhibition of IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95DMQPubMed
LigandPNGBDBM50530391(CHEMBL4444169)copy SMILEScopy InChI
Affinity DataIC50: 600nMAssay Description:Inhibition of TYK2 JH2 domain in mouse whole blood assessed as inhibition of IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95DMQPubMed
LigandPNGBDBM50519536(CHEMBL4559585)copy SMILEScopy InChI
Affinity DataIC50: 700nMAssay Description:Inhibition of TYK2 in mouse whole blood assessed as decrease in IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by stimulation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50519538(CHEMBL4580625)copy SMILEScopy InChI
Affinity DataIC50: 730nMAssay Description:Inhibition of TYK2 in mouse whole blood assessed as decrease in IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by stimulation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XJSPubMed
LigandPNGBDBM50530389(CHEMBL4438202)copy SMILEScopy InChI
Affinity DataIC50: 830nMAssay Description:Inhibition of TYK2 JH2 domain in mouse whole blood assessed as inhibition of IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95DMQPubMed
LigandPNGBDBM50530389(CHEMBL4438202)copy SMILEScopy InChI
Affinity DataIC50: 830nMAssay Description:Inhibition of TYK2 JH2 domain in mouse whole blood assessed as inhibition of IFNalpha-induced STAT1 phosphorylation preincubated for 1 hr followed by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W95DMQPubMed