Compile Data Set for Download or QSAR
Found 27 Enz. Inhib. hit(s) with Target = 'Procathepsin L [114-333,T223A]'
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31992(Dipeptidyl nitrile inhibitor, 25)copy SMILEScopy InChI
Affinity DataIC50: 13nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31993(Dipeptidyl nitrile inhibitor, 26)copy SMILEScopy InChI
Affinity DataIC50: 13nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31984(Dipeptidyl nitrile inhibitor, 17)copy SMILEScopy InChI
Affinity DataIC50: 20nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31980(Dipeptidyl nitrile inhibitor, 13)copy SMILEScopy InChI
Affinity DataIC50: 50nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31990(Dipeptidyl nitrile inhibitor, 23)copy SMILEScopy InChI
Affinity DataIC50: 63nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31991(Dipeptidyl nitrile inhibitor, 24)copy SMILEScopy InChI
Affinity DataIC50: 79nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31989(Dipeptidyl nitrile inhibitor, 22)copy SMILEScopy InChI
Affinity DataIC50: 79nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31977(Dipeptidyl nitrile inhibitor, 10)copy SMILEScopy InChI
Affinity DataIC50: 79nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31978(Dipeptidyl nitrile inhibitor, 11)copy SMILEScopy InChI
Affinity DataIC50: 79nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31983(Dipeptidyl nitrile inhibitor, 16)copy SMILEScopy InChI
Affinity DataIC50: 100nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31981(Dipeptidyl nitrile inhibitor, 14)copy SMILEScopy InChI
Affinity DataIC50: 251nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31974(Dipeptidyl nitrile inhibitor, 7)copy SMILEScopy InChI
Affinity DataIC50: 251nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31975(Dipeptidyl nitrile inhibitor, 8)copy SMILEScopy InChI
Affinity DataIC50: 251nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31970(Dipeptidyl nitrile inhibitor, 1)copy SMILEScopy InChI
Affinity DataIC50: 251nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31973(Dipeptidyl nitrile inhibitor, 6)copy SMILEScopy InChI
Affinity DataIC50: 316nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31979(Dipeptidyl nitrile inhibitor, 12)copy SMILEScopy InChI
Affinity DataIC50: 316nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31988(Dipeptidyl nitrile inhibitor, 21)copy SMILEScopy InChI
Affinity DataIC50: 398nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31982(Dipeptidyl nitrile inhibitor, 15)copy SMILEScopy InChI
Affinity DataIC50: 398nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31972(Dipeptidyl nitrile inhibitor, 5)copy SMILEScopy InChI
Affinity DataIC50: 501nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31986(Dipeptidyl nitrile inhibitor, 19)copy SMILEScopy InChI
Affinity DataIC50: 501nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31987(Dipeptidyl nitrile inhibitor, 20)copy SMILEScopy InChI
Affinity DataIC50: 631nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31976(Dipeptidyl nitrile inhibitor, 9)copy SMILEScopy InChI
Affinity DataIC50: 794nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31985(Dipeptidyl nitrile inhibitor, 18)copy SMILEScopy InChI
Affinity DataIC50: 1.26E+3nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM31971(Dipeptidyl nitrile inhibitor, 4)copy SMILEScopy InChI
Affinity DataIC50: 1.26E+3nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TT4PBMPubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM36812(CA-074)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMpH: 5.5 T: 2°CAssay Description:Inhibition assay using pre-treatment of recombinant cathepsin-L-like cysteine protease cruzain lacking the carboxy-terminal domain or cathepsin B fr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B2ZN5PubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM36813(CA-074b)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMpH: 5.5 T: 2°CAssay Description:Inhibition assay using pre-treatment of recombinant cathepsin-L-like cysteine protease cruzain lacking the carboxy-terminal domain or cathepsin B fr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B2ZN5PubMed
TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM36814(MB-074)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMpH: 5.5 T: 2°CAssay Description:Inhibition assay using pre-treatment of recombinant cathepsin-L-like cysteine protease cruzain lacking the carboxy-terminal domain or cathepsin B fr...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B2ZN5PubMed