Compile Data Set for Download or QSAR
Found 37 Enz. Inhib. hit(s) with Target = 'Protein mono-ADP-ribosyltransferase PARP16'
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM50609916(CHEMBL5284069)copy SMILES
Affinity DataIC50: 362nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM50594267(CHEMBL5189477)copy SMILES
Affinity DataIC50: 362nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26D5Z03PubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM50594267(CHEMBL5189477)copy SMILES
Affinity DataIC50: 362nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BZ6B2PPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM50594266(CHEMBL5172255)copy SMILES
Affinity DataIC50: 427nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26D5Z03PubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM50242630(CHEMBL4089522)copy SMILEScopy InChI
Affinity DataIC50: 560nMAssay Description:Inhibition of His6-tagged PARP16 (unknown origin) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5B5FPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM50145156(CHEMBL3764816)copy SMILEScopy InChI
Affinity DataIC50: 1.86E+3nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP16 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinyla...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054VVPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM50145156(CHEMBL3764816)copy SMILEScopy InChI
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP16 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinyla...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054VVPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16 [1-280](Homo sapiens (Human))
University of Oulu

LigandPNGBDBM199181(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)copy SMILEScopy InChI
Affinity DataIC50: 4.17E+3nMAssay Description:This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56HJ3PubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM199181(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)copy SMILEScopy InChI
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of N-terminal His-tagged human ARTD15 (1 to 280 residues) expressed in Escherichia coli Rosetta2 (DE3) after 24 hrs in presence of NAD+More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P271SWPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM50238425(CHEMBL4064332)copy SMILEScopy InChI
Affinity DataIC50: 5.01E+3nMAssay Description:Binding affinity to PARP16 in human Jurkat cell extract after 45 mins by mass spectrometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X350RSPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM50238428(CHEMBL4087876)copy SMILEScopy InChI
Affinity DataIC50: 5.01E+3nMAssay Description:Binding affinity to PARP16 in human Jurkat cell extract after 45 mins by mass spectrometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X350RSPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM50188594(CHEBI:62878 | CHEMBL1086580)copy SMILEScopy InChI
Affinity DataIC50: 5.01E+3nMAssay Description:Binding affinity to PARP16 in human Jurkat cell extract after 45 mins by mass spectrometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X350RSPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM50238416(CHEMBL4087470)copy SMILEScopy InChI
Affinity DataIC50: 5.01E+3nMAssay Description:Binding affinity to PARP16 in human Jurkat cell extract after 45 mins by mass spectrometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X350RSPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM50238419(CHEMBL4060134)copy SMILEScopy InChI
Affinity DataIC50: 5.01E+3nMAssay Description:Binding affinity to PARP16 in human Jurkat cell extract after 45 mins by mass spectrometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X350RSPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)copy SMILEScopy InChI
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP16 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinyla...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054VVPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)copy SMILEScopy InChI
Affinity DataIC50: 5.13E+3nMAssay Description:Inhibition of full length recombinant human His6-tagged PARP16 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinyla...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28054VVPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM50503853(CHEMBL4545565)copy SMILEScopy InChI
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of human transmembrane domain deficient His-SUMO-tagged PARP16 expressed in Escherichia coli BL21 assessed as reduction in MARylation of H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1GXVPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM50503853(CHEMBL4545565)copy SMILEScopy InChI
Affinity DataIC50: 6.76E+3nMAssay Description:Inhibition of human transmembrane domain deficient His-SUMO-tagged PARP16 expressed in Escherichia coli BL21 assessed as reduction in MARylation of H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1GXVPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM50340090(4-methoxybenzamide | CHEMBL449635)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal His-tagged human ARTD15 (1 to 280 residues) expressed in Escherichia coli Rosetta2 (DE3) after 24 hrs in presence of NAD+More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P271SWPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM50468579(CHEMBL4287262)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal His-tagged human ARTD15 (1 to 280 residues) expressed in Escherichia coli Rosetta2 (DE3) after 24 hrs in presence of NAD+More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P271SWPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM50452662(CHEMBL4208737)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal His-tagged human ARTD15 (1 to 280 residues) expressed in Escherichia coli Rosetta2 (DE3) after 24 hrs in presence of NAD+More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P271SWPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM50250875(CHEMBL4095003)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PARP16 using NAD+ as substrate by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CJ8GXGPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM50468581(CHEMBL4287655)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of N-terminal His-tagged human ARTD15 (1 to 280 residues) expressed in Escherichia coli Rosetta2 (DE3) after 24 hrs in presence of NAD+More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P271SWPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM50594011(CHEMBL5200521)copy SMILES
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20V8HSSPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM50594010(CHEMBL5200358)copy SMILES
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20V8HSSPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM50594005(CHEMBL5181947)copy SMILES
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20V8HSSPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM50593992(CHEMBL5186967)copy SMILES
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20V8HSSPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM431646(5-[[(2S)-1-(3-Oxo-3-[4-[5-(trifluoromethyl)pyrimid...)copy SMILES
Affinity DataIC50: 2.50E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26D5Z03PubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM50234915(CHEMBL4069447)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PARP16 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20R9RPPPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM50234916(CHEMBL4098188)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PARP16 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20R9RPPPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM50594268(CHEMBL5178746)copy SMILES
Affinity DataIC50: 2.96E+5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26D5Z03PubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM50594268(CHEMBL5178746)copy SMILES
Affinity DataIC50: 2.96E+5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BZ6B2PPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM50446130(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)copy SMILEScopy InChI
Affinity DataKd:  2.90E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z03D7JPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM50316226((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)copy SMILEScopy InChI
Affinity DataKd: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z03D7JPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM50084621(BMN 673 | Talazoparib)copy SMILEScopy InChI
Affinity DataKd:  1.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z03D7JPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM209932(2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-...)copy SMILEScopy InChI
Affinity DataKd: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z03D7JPubMed
TargetProtein mono-ADP-ribosyltransferase PARP16(Homo sapiens (Human))TBA
LigandPNGBDBM27566(4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbo...)copy SMILEScopy InChI
Affinity DataKd: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z03D7JPubMed