Compile Data Set for Download or QSAR
Found 50 Enz. Inhib. hit(s) with Target = 'Pyruvate kinase PKLR'
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50336799(5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino...)copy SMILEScopy InChI
Affinity DataKi:  1.10E+3nMAssay Description:Inhibitory activity against cell free dihydrofolate redutase (DHFR) from Mycobacterium lufuMore data for this Ligand-Target Pair
TargetPyruvate kinase PKLR(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367052(CHEMBL605425)copy SMILEScopy InChI
Affinity DataKi:  1.60E+6nMAssay Description:Inhibition of rat kidney pyruvate kinase (PK-L)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21N81PWPubMed
TargetPyruvate kinase PKLR(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50028624(CHEMBL3142978 | [6-(6-amino-9H-purin-9-yl)-2-methy...)copy SMILEScopy InChI
Affinity DataKi:  2.20E+6nMAssay Description:Inhibition of rat liver pyruvate kinase (PK-L) at 3.6 mMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21N81PWPubMed
TargetPyruvate kinase PKLR(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367051(CHEMBL606059)copy SMILEScopy InChI
Affinity DataKi:  2.20E+6nMAssay Description:Inhibition of rat kidney pyruvate kinase (PK-K)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21N81PWPubMed
TargetPyruvate kinase PKLR(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367051(CHEMBL606059)copy SMILEScopy InChI
Affinity DataKi:  2.20E+6nMAssay Description:Inhibition of rat muscle pyruvate kinase (PK-M)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21N81PWPubMed
TargetPyruvate kinase PKLR(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367051(CHEMBL606059)copy SMILEScopy InChI
Affinity DataKi:  2.90E+6nMAssay Description:Inhibition of rat kidney pyruvate kinase (PK-K)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21N81PWPubMed
TargetPyruvate kinase PKLR(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367052(CHEMBL605425)copy SMILEScopy InChI
Affinity DataKi:  3.80E+6nMAssay Description:Inhibitory constant for inhibition of pyruvate kinase obtained from rat liver (PK-L) was determined using ADP as competitive inhibitorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21N81PWPubMed
TargetPyruvate kinase PKLR(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367054(CHEMBL606476)copy SMILEScopy InChI
Affinity DataKi:  3.90E+6nMAssay Description:Inhibition of rat kidney pyruvate kinase (PK-K) at 6.7 mMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21N81PWPubMed
TargetPyruvate kinase PKLR(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50028624(CHEMBL3142978 | [6-(6-amino-9H-purin-9-yl)-2-methy...)copy SMILEScopy InChI
Affinity DataKi:  4.60E+6nMAssay Description:Inhibition of rat liver pyruvate kinase (PK-L); (relative inhibitory potency)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21N81PWPubMed
TargetPyruvate kinase PKLR(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367053(CHEMBL605428)copy SMILEScopy InChI
Affinity DataKi:  5.00E+6nMAssay Description:Inhibition of rat muscle pyruvate kinase (PK-M) at 6.7 mMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21N81PWPubMed
TargetPyruvate kinase PKLR(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367050(CHEMBL606006)copy SMILEScopy InChI
Affinity DataKi:  5.40E+6nMAssay Description:Inhibition of rat kidney pyruvate kinase (PK-K)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21N81PWPubMed
TargetPyruvate kinase PKLR(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50028625(CHEMBL3142968 | [5-(6-amino-9H-purin-9-yl)-4-hydro...)copy SMILEScopy InChI
Affinity DataKi:  7.00E+6nMAssay Description:Inhibitory constant for inhibition of pyruvate kinase obtained from rat liver (PK-L) was determined using ADP as competitive inhibitorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21N81PWPubMed
TargetPyruvate kinase PKLR(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367053(CHEMBL605428)copy SMILEScopy InChI
Affinity DataKi:  7.50E+6nMAssay Description:Inhibitory constant for inhibition of pyruvate kinase obtained from rat liver (PK-L) was determined using ADP as competitive inhibitorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21N81PWPubMed
TargetPyruvate kinase PKLR(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367050(CHEMBL606006)copy SMILEScopy InChI
Affinity DataKi:  8.00E+6nMAssay Description:Michaelis-Menten constant for inhibition of rat kidney pyruvate kinase (PK-K)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21N81PWPubMed
TargetPyruvate kinase PKLR(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367054(CHEMBL606476)copy SMILEScopy InChI
Affinity DataKi:  8.40E+6nMAssay Description:Inhibitory constant for inhibition of pyruvate kinase obtained from rat liver (PK-L) was determined using ADP as competitive inhibitorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21N81PWPubMed
TargetPyruvate kinase PKLR(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50367050(CHEMBL606006)copy SMILEScopy InChI
Affinity DataKi:  1.09E+7nMAssay Description:Inhibition of rat kidney pyruvate kinase (PK-K) at 6.7 mMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21N81PWPubMed
TargetPyruvate kinase PKLR(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50028625(CHEMBL3142968 | [5-(6-amino-9H-purin-9-yl)-4-hydro...)copy SMILEScopy InChI
Affinity DataKi:  3.20E+7nMAssay Description:Inhibition of rat kidney pyruvate kinase (PK-K)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21N81PWPubMed
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50596765(CHEMBL5204170)copy SMILES
Affinity DataIC50: 150nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50596761(CHEMBL5209097)copy SMILES
Affinity DataIC50: 160nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50596751(CHEMBL5176753)copy SMILES
Affinity DataIC50: 200nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0MJ9PubMed
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50143419(CHEMBL175336 | Sodium; 3,4-dihydroxy-9,10-dioxo-9,...)copy SMILEScopy InChI
Affinity DataIC50: 200nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0MJ9PubMed
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50596768(CHEMBL5208105)copy SMILES
Affinity DataIC50: 200nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50596767(CHEMBL5176181)copy SMILES
Affinity DataIC50: 290nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0MJ9PubMed
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50596760(CHEMBL5181251)copy SMILES
Affinity DataIC50: 300nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0MJ9PubMed
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50596766(CHEMBL5204537)copy SMILES
Affinity DataIC50: 550nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0MJ9PubMed
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50596759(CHEMBL5188496)copy SMILES
Affinity DataIC50: 700nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0MJ9PubMed
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50596755(CHEMBL5183208)copy SMILES
Affinity DataIC50: 900nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0MJ9PubMed
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50596756(CHEMBL5186564)copy SMILES
Affinity DataIC50: 1.20E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0MJ9PubMed
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50596764(CHEMBL5206382)copy SMILES
Affinity DataIC50: 1.30E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0MJ9PubMed
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50596773(CHEMBL5195754)copy SMILES
Affinity DataIC50: 1.30E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0MJ9PubMed
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50596757(CHEMBL5186706)copy SMILES
Affinity DataIC50: 1.40E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0MJ9PubMed
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50596771(CHEMBL5181273)copy SMILES
Affinity DataIC50: 1.40E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0MJ9PubMed
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50596772(CHEMBL5200212)copy SMILES
Affinity DataIC50: 1.70E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0MJ9PubMed
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50596763(CHEMBL5198643)copy SMILES
Affinity DataIC50: 1.90E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0MJ9PubMed
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50336799(5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino...)copy SMILEScopy InChI
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibitory activity against cell free dihydrofolate redutase (DHFR) from Escherichia coliMore data for this Ligand-Target Pair
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50596774(CHEMBL5177546)copy SMILES
Affinity DataIC50: 2.50E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0MJ9PubMed
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50596770(CHEMBL5170574)copy SMILES
Affinity DataIC50: 3.40E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0MJ9PubMed
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50596775(CHEMBL5169856)copy SMILES
Affinity DataIC50: 3.80E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0MJ9PubMed
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50271046(CHEMBL4127005)copy SMILEScopy InChI
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PKL expressed in Escherichia coli preincubated for 15 mins followed by PEP/NADH addition measur...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B62NMPubMed
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50596758(CHEMBL5172724)copy SMILES
Affinity DataIC50: 4.10E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0MJ9PubMed
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50596762(CHEMBL5170819)copy SMILES
Affinity DataIC50: 4.80E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50596752(CHEMBL5172682)copy SMILES
Affinity DataIC50: 5.80E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50596769(CHEMBL5193313)copy SMILES
Affinity DataIC50: 7.30E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0MJ9PubMed
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50596753(CHEMBL5209293)copy SMILES
Affinity DataIC50: 7.50E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0MJ9PubMed
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50271043(CHEMBL4128703)copy SMILEScopy InChI
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PKL expressed in Escherichia coli preincubated for 15 mins followed by PEP/NADH addition measur...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B62NMPubMed
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50029022(CHEMBL3339205)copy SMILEScopy InChI
Affinity DataIC50: 1.82E+4nMAssay Description:Inhibition of purified human N-terminal His-tagged PK-R by LDH-coupled continuous assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0GQKPubMed
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50596754(CHEMBL5188932)copy SMILES
Affinity DataIC50: 1.90E+4nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50029022(CHEMBL3339205)copy SMILEScopy InChI
Affinity DataIC50: 2.15E+4nMAssay Description:Inhibition of purified human N-terminal His-tagged PK-L by LDH-coupled continuous assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0GQKPubMed
TargetPyruvate kinase PKLR(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50033731((R)-5,8-dihydroxy-2-(1-hydroxy-4-methylpent-3-enyl...)copy SMILEScopy InChI
Affinity DataIC50: 3.93E+4nMAssay Description:Inhibition of recombinant human N-terminal His-tagged PKL expressed in Escherichia coli preincubated for 15 mins followed by PEP/NADH addition measur...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B62NMPubMed
TargetPyruvate kinase PKLR(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50016876(CHEMBL3278432)copy SMILEScopy InChI
Affinity DataKd:  3.60E+7nMAssay Description:Binding affinity to Sprague-Dawley rat pyruvate kinase L assessed as apprent enzyme-inhibitor dissociation constant using PEP as substrate by spectro...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2571DKJPubMed