Compile Data Set for Download or QSAR
Found 14 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase Sgk2'
TargetSerine/threonine-protein kinase Sgk2(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50463479(CHEMBL4249925)copy SMILEScopy InChI
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of SGK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZC85HXPubMed
TargetSerine/threonine-protein kinase Sgk2(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50463483(CHEMBL4245242)copy SMILEScopy InChI
Affinity DataKi: >2.00E+3nMAssay Description:Inhibition of SGK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZC85HXPubMed
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI
Affinity DataIC50: 15.2nMAssay Description:Inhibition of human SGK2 using KGSGSGRPRTSSFAEG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5KB8PubMed
TargetSerine/threonine-protein kinase Sgk2(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI
Affinity DataIC50: 16.5nMAssay Description:Inhibition of human SGK2 using KGSGSGRPRTSSFAEG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W380MTPubMed
LigandPNGBDBM269003(N-[4-(3-Amino-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-ph...)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of human SGK2 in presence 500 uM presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P55SCWPubMed
TargetSerine/threonine-protein kinase Sgk2(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50443628(CHEMBL3092468 | US9174993, 35 | US9221828, 35)copy SMILEScopy InChI
Affinity DataIC50: 128nMAssay Description:Inhibition of human SGK2 in presence of 500 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28S4RJTPubMed
TargetSerine/threonine-protein kinase Sgk2(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50443636(CHEMBL3092460 | US9174993, 1 | US9221828, 1)copy SMILEScopy InChI
Affinity DataIC50: 924nMAssay Description:Inhibition of human SGK2 in presence of 500 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28S4RJTPubMed
TargetSerine/threonine-protein kinase Sgk2(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50462709(CHEMBL4245507)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of SGK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP77MHPubMed
TargetSerine/threonine-protein kinase Sgk2(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50429867(CHEMBL2333365)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SGK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZC847XPubMed
TargetSerine/threonine-protein kinase Sgk2(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50519662(CHEMBL4438748)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human SGK2 S416D mutant (54 to end residues) using GRPRTSSFAEGKK as substrate incubated for 40 mins in presence of [gamma33...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC93FGPubMed
TargetSerine/threonine-protein kinase Sgk2(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50135286(CHEMBL3745885)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human SGK2 using [KGSGSGRPRTSSFAEG] as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7WT8PubMed
LigandPNGBDBM50537742(CHEMBL4634634 | US11179389, Compound 1-14)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human GST-tagged SGK2 catalytic domain (54 to 427 residues) expressed in baculovirus expression system using serine/threoni...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM5CZGPubMed
TargetSerine/threonine-protein kinase Sgk2(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50505541(CHEMBL4465866)copy SMILEScopy InChI
Affinity DataKd:  1.22E+3nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-tagged SGK2 (unknown origin) expressed in baculovirus infected Sf9 insect cells incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0S0KPubMed
TargetSerine/threonine-protein kinase Sgk2(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50505542(CHEMBL4576489)copy SMILEScopy InChI
Affinity DataKd:  1.77E+3nMAssay Description:Binding affinity to recombinant full-length N-terminal His-FLAG-tagged SGK2 (unknown origin) expressed in baculovirus infected Sf9 insect cells incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0S0KPubMed