Compile Data Set for Download or QSAR
Found 368 Enz. Inhib. hit(s) with Target = 'Sodium/bile acid cotransporter'
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50421815(CHEMBL5276478)copy SMILEScopy InChI
Affinity DataKi:  2.55E+3nMMore data for this Ligand-Target Pair
In DepthDetails
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50421812(CHEMBL5279244)copy SMILEScopy InChI
Affinity DataKi:  4.21E+3nMMore data for this Ligand-Target Pair
In DepthDetails
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50421811(CHEMBL5287944)copy SMILEScopy InChI
Affinity DataKi:  5.38E+3nMMore data for this Ligand-Target Pair
In DepthDetails
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50421813(CHEMBL5272039)copy SMILEScopy InChI
Affinity DataKi:  9.29E+3nMMore data for this Ligand-Target Pair
In DepthDetails
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50421814(CHEMBL5287717)copy SMILEScopy InChI
Affinity DataKi:  1.18E+4nMMore data for this Ligand-Target Pair
In DepthDetails
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50042235(2-butyl-3-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4...)copy SMILEScopy InChI
Affinity DataKi:  1.19E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X352HGPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50088504(A-84538 | ABBOTT-84538 | CHEBI:45409 | Norvir | Ri...)copy SMILEScopy InChI
Affinity DataKi:  1.84E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X352HGPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50371521(EZETIMIBE)copy SMILEScopy InChI
Affinity DataKi:  2.50E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X352HGPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50576171(CHEMBL4875567)copy SMILES
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells pretreated for 2 hrs followed by [3H]-TCA addition in absence of FBSMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27948HFPubMed
TargetSodium/bile acid cotransporter(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50150325(3-[4-(4-{[Benzyl-(3-methanesulfonylamino-2-methyl-...)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Inhibition of [3H]taurocholate uptake in rat hepatocytesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1RTKPubMed
TargetSodium/bile acid cotransporter(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50150349(CHEMBL266407 | Methanesulfonamide derivative)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of [3H]taurocholate uptake in rat hepatocytesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1RTKPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50576163(CHEMBL4864019)copy SMILES
Affinity DataIC50: 14nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells after 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27948HFPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50576165(CHEMBL4875540)copy SMILES
Affinity DataIC50: 14nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells after 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27948HFPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50576164(CHEMBL4869726)copy SMILES
Affinity DataIC50: 14nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells after 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27948HFPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50576166(CHEMBL4861143)copy SMILES
Affinity DataIC50: 14nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells after 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27948HFPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50576162(CHEMBL4849233)copy SMILES
Affinity DataIC50: 14nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells after 2 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27948HFPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50576168(CHEMBL4855155)copy SMILES
Affinity DataIC50: 18nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells pretreated for 2 hrs followed by [3H]-TCA addition in absence of FBSMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27948HFPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50576169(CHEMBL4865557)copy SMILES
Affinity DataIC50: 24nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells pretreated for 2 hrs followed by [3H]-TCA addition in absence of FBSMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27948HFPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50576167(CHEMBL4862057)copy SMILES
Affinity DataIC50: 25nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells pretreated for 2 hrs followed by [3H]-TCA addition in absence of FBSMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27948HFPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50576162(CHEMBL4849233)copy SMILES
Affinity DataIC50: 36nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells pretreated for 2 hrs followed by [3H]-TCA addition in absence of FBSMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27948HFPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50576170(CHEMBL4858170)copy SMILES
Affinity DataIC50: 38nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells pretreated for 2 hrs followed by [3H]-TCA addition in absence of FBSMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27948HFPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50576169(CHEMBL4865557)copy SMILES
Affinity DataIC50: 54nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells in presence of 20 % FBSMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27948HFPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50576165(CHEMBL4875540)copy SMILES
Affinity DataIC50: 58nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27948HFPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50556959(CHEMBL4781848)copy SMILES
Affinity DataIC50: 66nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells incubated for 2 hrs followed by substrate addition and measured for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F76H7PPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50576169(CHEMBL4865557)copy SMILES
Affinity DataIC50: 82nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells in presence of 50 % FBSMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27948HFPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50576168(CHEMBL4855155)copy SMILES
Affinity DataIC50: 109nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells in presence of 20 % FBSMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27948HFPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50576168(CHEMBL4855155)copy SMILES
Affinity DataIC50: 167nMAssay Description:Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells in presence of 50 % FBSMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27948HFPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50157077(CHEMBL184982 | {(R)-4-[(4R,10aS,12aR)-4-Hydroxy-8-...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:In vitro inhibition of taurocholate binding to liver bile acid transporter expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VT1RKRPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50157075(2-[(4R)-4-[(2S,18R)-6-{2-[(6,7-dimethoxy-1,2,3,4-t...)copy SMILEScopy InChI
Affinity DataIC50: 220nMAssay Description:In vitro inhibition of taurocholate binding to liver bile acid transporter expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VT1RKRPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50157074(CHEMBL182671 | {(R)-4-[(4R,10aS,12aR)-4-Hydroxy-8-...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:In vitro inhibition of taurocholate binding to liver bile acid transporter expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VT1RKRPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50157072(CHEMBL367757 | {(R)-4-[(10aS,12aR)-8-(3-Hydroxy-be...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:In vitro inhibition of taurocholate binding to liver bile acid transporter expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VT1RKRPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50157079(CHEMBL182301 | [(R)-4-((4R,10aS,12aR)-4-Hydroxy-10...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:In vitro inhibition of taurocholate binding to liver bile acid transporter expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VT1RKRPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50157076(CHEMBL185033 | {(R)-4-[(10aS,12aR)-8-(2-Hydroxy-et...)copy SMILEScopy InChI
Affinity DataIC50: 700nMAssay Description:In vitro inhibition of taurocholate binding to liver bile acid transporter expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VT1RKRPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50009073(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X352HGPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50103596((E)-2-hydroxy-5-((4-(N-pyridin-2-ylsulfamoyl)-phen...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X352HGPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50022815((3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:TP_TRANSPORTER: inhibition of Taurocholate uptake in NTCP-expressing HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NS0W06PubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50113317(Bis[4-Amino-5-hydroxy-6-(2-methoxy-phenylazo)-naph...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X352HGPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50157078(CHEMBL185179 | [(R)-4-((10aS,12aR)-10a,12a-Dimethy...)copy SMILEScopy InChI
Affinity DataIC50: 1.60E+3nMAssay Description:In vitro inhibition of taurocholate binding to liver bile acid transporter expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VT1RKRPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50386790(CHEMBL1829174 | CHEMBL2047159 | TAK-875 | US119052...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of NTCP in human hepatocytesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GM8BR6PubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50157080(2-[(4R)-4-[(2S,12R,18R)-12-hydroxy-6-[(3-{[(2S)-2-...)copy SMILEScopy InChI
Affinity DataIC50: 3.40E+3nMAssay Description:In vitro inhibition of taurocholate binding to liver bile acid transporter expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VT1RKRPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM53721((4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-10,13-dim...)copy SMILEScopy InChI
Affinity DataIC50: 3.60E+3nMAssay Description:TP_TRANSPORTER: inhibition of Taurocholate uptake in NTCP-expressing HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NS0W06PubMedDrugBank
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50601893(DIHYDROBETULIN | Dihydrobetulin)copy SMILES
Affinity DataIC50: 4.00E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X352HGPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50030474(Avandamet | Avandaryl | Avandia | BRL-49653 | CHEB...)copy SMILEScopy InChI
Affinity DataIC50: 5.10E+3nMAssay Description:Inhibition of HA-tagged human NTCP expressed in human U2OS cells assessed as reduction in [14C]taurocholate uptake preincubated for 10 mins followed ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GM8BR6PubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50375594(TAUROCHOLATE)copy SMILEScopy InChI
Affinity DataIC50: 5.30E+3nMAssay Description:TP_TRANSPORTER: inhibition of Taurocholate uptake in NTCP-expressing HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NS0W06PubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM25761(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)copy SMILEScopy InChI
Affinity DataIC50: 5.50E+3nMAssay Description:TP_TRANSPORTER: inhibition of Taurocholate uptake in NTCP-expressing HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NS0W06PubMed
TargetSodium/bile acid cotransporter(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50375594(TAUROCHOLATE)copy SMILEScopy InChI
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of [3H]taurocholate uptake in rat hepatocytesMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1RTKPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50601888(Betulin-3-Caffeate | Betulin-3Beta-Caffeate | CHEM...)copy SMILES
Affinity DataIC50: 6.00E+3nMMore data for this Ligand-Target Pair
Ligand InfoMCE
PC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X352HGPubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50246936((-)-(S)-Propranolol | 1-(ISOPROPYLAMINO)-3-(1-NAPH...)copy SMILEScopy InChI
Affinity DataIC50: 6.10E+3nMAssay Description:TP_TRANSPORTER: inhibition of Taurocholate uptake in NTCP-expressing HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NS0W06PubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50009073(4-(5-cyclopentyloxycarbonylamino-1-methyl-1H-indol...)copy SMILEScopy InChI
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of HA-tagged human NTCP expressed in human U2OS cells assessed as reduction in [14C]taurocholate uptake preincubated for 10 mins followed ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GM8BR6PubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))TBA
LigandPNGBDBM50601891(CHEMBL5184124)copy SMILES
Affinity DataIC50: 6.50E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X352HGPubMed
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