Compile Data Set for Download or QSAR
Found 176 Enz. Inhib. hit(s) with Target = 'Sodium channel protein type 3 subunit alpha'
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50344821(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)copy SMILEScopy InChI
Affinity DataIC50: 5.30nMAssay Description:Inhibition of human Nav1.3 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90CZDPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM190233(US9174999, Table 1, Compound 1)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of human Nav1.3 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90CZDPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50077471(CHEMBL3416886)copy SMILES
Affinity DataIC50: 20nMAssay Description:Inhibition of human NaV1.3 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F47QVKPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50118516(CHEMBL3617053)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of human TTX-sensitive NaV1.3 channel expressed in HEK293 cells by patch clamp electrophysiology assayMore data for this Ligand-Target Pair
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50051073(CHEMBL3318132)copy SMILES
Affinity DataIC50: 25nMAssay Description:Inhibition of human Nav1.3 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90CZDPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50344821(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of voltage-gated Na channel 1.3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B61GZPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50426577(CHEMBL2324354)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of human voltage-gated Na channel 1.3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B61GZPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50520478(CHEMBL4436427)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of Nav1.3 (unknown origin) expressed in Xenopus laevis oocytes at -80 mV holding potential by two electrode voltage-clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ93SZPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50520499(CHEMBL4517378)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibition of Nav1.3 (unknown origin) expressed in Xenopus laevis oocytes at -80 mV holding potential by two electrode voltage-clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ93SZPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50505258(CHEMBL4588728)copy SMILEScopy InChI
Affinity DataIC50: 210nMAssay Description:Inhibition of human Nav1.3 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90CZDPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50520496(CHEMBL4469517)copy SMILEScopy InChI
Affinity DataIC50: 260nMAssay Description:Inhibition of Nav1.3 (unknown origin) expressed in Xenopus laevis oocytes at -80 mV holding potential by two electrode voltage-clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ93SZPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50257215(CHEMBL2324411)copy SMILEScopy InChI
Affinity DataIC50: 292nMAssay Description:Inhibition of human NaV1.3 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0PQFPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50349984(CHEMBL1813048)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Inhibition of 20% inactivated TTX-resistant human sodium channel Nav1.3 expressed in human HEK293 cells at 1 uM by patch-clamp electrophysiological a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N016W1PubMed
TargetSodium channel protein type 3 subunit alpha(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118517(CHEMBL3617067)copy SMILEScopy InChI
Affinity DataIC50: 375nMAssay Description:Inhibition of rat NaV1.3 channelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XS5X6PPubMed
TargetSodium channel protein type 3 subunit alpha(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50300204((2R)-2-acetylamino-N-benzyl-3-methoxypropanamide |...)copy SMILEScopy InChI
Affinity DataIC50: 415nMAssay Description:Binding affinity to rat inactivated voltage-gated Na channel 1.3 expressed in human HEK293 cells by patch-clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B61GZPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50017659(2-(Dimethylamino)ethyl p-(butylamino)benzoate | 2-...)copy SMILEScopy InChI
Affinity DataIC50: 740nMAssay Description:Inhibition of recombinant human Nav1.3 expressed in HEK293 cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C250GWPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50371391(SENICAPOC)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of voltage-gated Na channel 1.3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B61GZPubMed
TargetSodium channel protein type 3 subunit alpha(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50004782(CHEMBL2324353)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of rat voltage-gated Na channel 1.3 in dorsal root ganglion neurons by patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B61GZPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50212239(5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-...)copy SMILEScopy InChI
Affinity DataIC50: 2.45E+3nMAssay Description:Inhibition of human Nav1.3 channel expressed in HEK293 cells at -60 mV by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J10411PubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50212239(5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-...)copy SMILEScopy InChI
Affinity DataIC50: 2.45E+3nMAssay Description:Inhibition of inactivated human Nav1.3 sodium channelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22J6BJBPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50257182(CHEMBL2324753)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human NaV1.3 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0PQFPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50500961(CHEMBL3798363)copy SMILEScopy InChI
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of recombinant human Nav1.3 expressed in HEK293 cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C250GWPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50095314(CHEMBL3589893)copy SMILEScopy InChI
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human Nav1.3 expressed in SHSY5Y cells assessed as reduction in blue fluorescent signal by VSP-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0VMJPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)copy SMILES
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of NaV1.3 (unknown origin) at 25 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ36DMPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50008745(CHEMBL3236329)copy SMILEScopy InChI
Affinity DataIC50: 4.76E+3nMAssay Description:Inhibition of human Nav1.3 assessed as inactivated-state block by patch-clamp electrophysiology/cell based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ38QJPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of human Nav1.3 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90CZDPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50451447(CHEMBL4217988)copy SMILEScopy InChI
Affinity DataIC50: 6.44E+3nMAssay Description:Inhibition of human Nav1.3 expressed in HEK cells by patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4ZN1PubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM342904(1-(2-fluoro-5-methoxy-3'-(trifluoromethyl)-4-biphe...)copy SMILEScopy InChI
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of human Nav1.3 expressed in CHO cells assessed as reduction in peak inward current by ionworks quattro electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4MS7PubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50095313(CHEMBL3589892)copy SMILEScopy InChI
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of human Nav1.3 expressed in SHSY5Y cells assessed as reduction in blue fluorescent signal by VSP-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0VMJPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM344708(1-[1-(2-fluorophenyl)-1H-indazol-4-yl]-3-{2-[(3S)-...)copy SMILEScopy InChI
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of recombinant human Nav1.3 expressed in HEK293 cells preincubated for 40 mins followed by DiSBAC2 substrate addition measured after 90 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C250GWPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50495865(CHEMBL3113259)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+3nMAssay Description:Modulation of human Nav1.3 in open-inactivated state assessed as inhibition of inward current after 4 mins by whole-cell electrophysiologyMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69NJWPubMed
TargetSodium channel protein type 3 subunit alpha(Rattus norvegicus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50242400(CCNCSSKWCRDHSRCC | CHEMBL525818)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of rat Nav1.3 channel expressed in Xenopus oocytes by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028RBXPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50118514(CHEMBL3617063 | US9481677, 38)copy SMILEScopy InChI
Affinity DataIC50: 9.33E+3nMAssay Description:Inhibition of full length human Nav1.3 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -50 mV by...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J1052WPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50257177(CHEMBL2324748)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human NaV1.3 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0PQFPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50240267(CHEMBL2325014)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human NaV1.3 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0PQFPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50095312(CHEMBL2324355)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Nav1.3 expressed in SHSY5Y cells by IonWorks Quattro selectivity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0VMJPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50349984(CHEMBL1813048)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of fully inactivated TTX-resistant human sodium channel Nav1.3 expressed in human HEK293 cells at 1 uM by patch-clamp electrophysiological...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N016W1PubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50257175(CHEMBL2324776)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human NaV1.3 expressed in HEK cells assessed as half inactivation potential at -120 mV holding potential by automated patch clamp metho...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0PQFPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50017662(2-(Diethylamino)-2',6'-acetoxylidide | 2-(Diethyla...)copy SMILEScopy InChI
Affinity DataIC50: 1.05E+4nMAssay Description:Modulation of human Nav1.3 in open-inactivated state assessed as inhibition of inward current after 4 mins by whole-cell electrophysiologyMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69NJWPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50240267(CHEMBL2325014)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of human Nav1.3 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90CZDPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50212239(5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-...)copy SMILEScopy InChI
Affinity DataIC50: 1.18E+4nMAssay Description:Inhibition of human Nav1.3 channel expressed in HEK293 cells at -120 mV by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J10411PubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50495850(CHEMBL3113255)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+4nMAssay Description:Modulation of human Nav1.3 in open-inactivated state assessed as inhibition of inward current after 4 mins by whole-cell electrophysiologyMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69NJWPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50495853(CHEMBL3113247)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+4nMAssay Description:Modulation of human Nav1.3 in open-inactivated state assessed as inhibition of inward current after 4 mins by whole-cell electrophysiologyMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69NJWPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM329203(4-(5-Chloro-6-((1-Methylcyclopropyl)Methoxy)Pyridi...)copy SMILEScopy InChI
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of human Nav1.3 expressed in CHO cells assessed as reduction in peak inward current by manual whole cell patch clamp electrophysiology ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q50KXPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50495860(CHEMBL3113260)copy SMILEScopy InChI
Affinity DataIC50: 1.30E+4nMAssay Description:Modulation of human Nav1.3 in open-inactivated state assessed as inhibition of inward current after 4 mins by whole-cell electrophysiologyMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69NJWPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM217483(US9212182, 477 | US9212182, 478)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human Nav1.3 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90CZDPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50095310(CHEMBL3589894)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human Nav1.3 expressed in SHSY5Y cells assessed as reduction in blue fluorescent signal by VSP-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0VMJPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM217483(US9212182, 477 | US9212182, 478)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human Nav1.3 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90CZDPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50520500(CHEMBL4451222)copy SMILEScopy InChI
Affinity DataIC50: 1.57E+4nMAssay Description:Inhibition of Nav1.3 (unknown origin) expressed in Xenopus laevis oocytes at -80 mV holding potential by two electrode voltage-clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ93SZPubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
SiteOne Therapeutics

Curated by ChEMBL
LigandPNGBDBM50563816(Eleclazine | GS-6615)copy SMILES
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of NaV1.3 (unknown origin) at 10 Hz frequency by whole cell manual patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ36DMPubMed
Displayed 1 to 50 (of 176 total ) | Next | Last >>
Jump to: