Compile Data Set for Download or QSAR
Found 273 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2 [831-1132]'
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM50503287(ABT-494 | Rinvoq | US10961228, Example ABT-494 | U...)copy SMILEScopy InChI
Affinity DataIC50: 64nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20G3P8FUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM488640(US10961228, Example Tofacitinib | US11414413, Exam...)copy SMILES
Affinity DataIC50: 130nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20G3P8FUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM488735((S)-2-((3R,5R)-3,5- dimethylpiperazin-1- yl)-N-(3-...)copy SMILES
Affinity DataIC50: 162nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20G3P8FUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM489172((R)-2-((R)-2,4- dimethylpiperazin-1- yl)-N-(3-(2-(...)copy SMILES
Affinity DataIC50: 293nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20G3P8FUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264233((2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amin...)copy SMILEScopy InChI
Affinity DataIC50: 322nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29G5R1PUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264233((2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amin...)copy SMILEScopy InChI
Affinity DataIC50: 322nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29C71F3US Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264233((2R)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amin...)copy SMILEScopy InChI
Affinity DataIC50: 322nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VQ34PCUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM488719((R)-2-((3R,5R)-3,5- dimethylpiperazin-1- yl)-N-(3-...)copy SMILES
Affinity DataIC50: 456nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20G3P8FUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM489047((R)-N-(3-(2-((2-fluoro- 3- (methylsulfonyl)phenyl)...)copy SMILES
Affinity DataIC50: 604nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20G3P8FUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM489168((R)-2-((R)-2,4- dimethylpiperazin-1- yl)-N-(3-(2-(...)copy SMILES
Affinity DataIC50: 612nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20G3P8FUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM489174((R)-2-((R)-2,4- dimethylpiperazin-1- yl)-N-(3-(5-f...)copy SMILES
Affinity DataIC50: 709nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20G3P8FUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM489073((R)-N-(3-(5-fluoro-2- ((2-fluoro-3- (methylsulfony...)copy SMILES
Affinity DataIC50: 718nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20G3P8FUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM488689((R)-N-(3-(2-((2-fluoro- 3- (methylsulfonyl)phenyl)...)copy SMILES
Affinity DataIC50: 725nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20G3P8FUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264225((2R)-3-methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-p...)copy SMILES
Affinity DataIC50: 790nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29C71F3US Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264225((2R)-3-methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-p...)copy SMILES
Affinity DataIC50: 790nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VQ34PCUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264225((2R)-3-methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-p...)copy SMILES
Affinity DataIC50: 790nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29G5R1PUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM489180((R)-3-(benzyloxy)-N- 3-(2-((2-fluoro-3- (methylsul...)copy SMILES
Affinity DataIC50: 910nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20G3P8FUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM488809((R)-N-(3-(2-((2-fluoro-3- (methylsulfonyl)phenyl) ...)copy SMILES
Affinity DataIC50: 968nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20G3P8FUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM488761((S)-2-((3R,5R)-3,5- dimethylpiperazin-1- yl)-N-(3-...)copy SMILES
Affinity DataIC50: 1.16E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20G3P8FUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM488758((R)-2-((3R,5R)-3,5- dimethylpiperazin-1- yl)-N-(3-...)copy SMILES
Affinity DataIC50: 1.20E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20G3P8FUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM488779((R)-N-(3-(5-fluoro-2- (2-fluoro-3- (methylsulfonyl...)copy SMILES
Affinity DataIC50: 1.22E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20G3P8FUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264240((2R)-3-Methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-p...)copy SMILES
Affinity DataIC50: 1.53E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29G5R1PUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264240((2R)-3-Methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-p...)copy SMILES
Affinity DataIC50: 1.53E+3nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VQ34PCUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264240((2R)-3-Methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-p...)copy SMILES
Affinity DataIC50: 1.53E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29C71F3US Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM488661((R)-N-(3-(2-((2-fluoro- 3- (methylsulfonyl)phenyl)...)copy SMILES
Affinity DataIC50: 1.58E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20G3P8FUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264217((2R)-N-(3-{5-bromo- 2-[(3-methoxy-1- methyl-1H-pyr...)copy SMILES
Affinity DataIC50: 1.58E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29C71F3US Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264217((2R)-N-(3-{5-bromo- 2-[(3-methoxy-1- methyl-1H-pyr...)copy SMILES
Affinity DataIC50: 1.58E+3nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VQ34PCUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264217((2R)-N-(3-{5-bromo- 2-[(3-methoxy-1- methyl-1H-pyr...)copy SMILES
Affinity DataIC50: 1.58E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29G5R1PUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM488667((R)-N-(3-(2-(3- cyclopropylsulfonyl)- 2-fluorophen...)copy SMILES
Affinity DataIC50: 1.60E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20G3P8FUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264216((2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-py...)copy SMILES
Affinity DataIC50: 1.76E+3nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VQ34PCUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264216((2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-py...)copy SMILES
Affinity DataIC50: 1.76E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29C71F3US Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264216((2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-py...)copy SMILES
Affinity DataIC50: 1.76E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29G5R1PUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264229((2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amin...)copy SMILES
Affinity DataIC50: 1.77E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29C71F3US Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264229((2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amin...)copy SMILES
Affinity DataIC50: 1.77E+3nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VQ34PCUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264229((2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amin...)copy SMILES
Affinity DataIC50: 1.77E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29G5R1PUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM488763((R)-2-((3R,5R)-3,5- dimethylpiperazin-1- yl)-N-(3-...)copy SMILES
Affinity DataIC50: 1.79E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20G3P8FUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM488777((R)-2-((3R,5R)-3,5- dimethylpiperazin-1- yl)-N-(3-...)copy SMILES
Affinity DataIC50: 1.93E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20G3P8FUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264224((2R)-N-(3-{2-[(3- Methoxy-1-methyl- 1H-pyrazol-4-y...)copy SMILES
Affinity DataIC50: 1.95E+3nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VQ34PCUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264224((2R)-N-(3-{2-[(3- Methoxy-1-methyl- 1H-pyrazol-4-y...)copy SMILES
Affinity DataIC50: 1.95E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29C71F3US Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264224((2R)-N-(3-{2-[(3- Methoxy-1-methyl- 1H-pyrazol-4-y...)copy SMILES
Affinity DataIC50: 1.95E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29G5R1PUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM313401((2R)-N-(3-{2-[(3-ethoxy-1-methyl-1H- pyrazol-4-yl)...)copy SMILES
Affinity DataIC50: 2.04E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29G5R1PUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM313401((2R)-N-(3-{2-[(3-ethoxy-1-methyl-1H- pyrazol-4-yl)...)copy SMILES
Affinity DataIC50: 2.04E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29C71F3US Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264244((2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 2.04E+3nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VQ34PCUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM489170((R)-2-((R)-2,4- dimethylpiperazin-1- yl)-N-(3-(5-f...)copy SMILES
Affinity DataIC50: 2.08E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20G3P8FUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM488685((R)-N-(3-(2-((2-fluoro- 3- (methylsulfonyl)phenyl)...)copy SMILES
Affinity DataIC50: 2.43E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20G3P8FUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264194((2R)-2-[4-(2- hydroxyethyl)piperazin- 1-yl]-N-(3-{...)copy SMILES
Affinity DataIC50: 2.53E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29G5R1PUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264194((2R)-2-[4-(2- hydroxyethyl)piperazin- 1-yl]-N-(3-{...)copy SMILES
Affinity DataIC50: 2.53E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29C71F3US Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264194((2R)-2-[4-(2- hydroxyethyl)piperazin- 1-yl]-N-(3-{...)copy SMILES
Affinity DataIC50: 2.53E+3nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VQ34PCUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM488710((R)-N-(3-(2-((2-fluoro- 3- (methylsulfonyl)phenyl)...)copy SMILES
Affinity DataIC50: 2.56E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20G3P8FUS Patent
TargetTyrosine-protein kinase JAK2 [831-1132](Homo sapiens (Human))
ASTRAZENECA AB

US Patent
LigandPNGBDBM264221((2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amin...)copy SMILES
Affinity DataIC50: 2.58E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29C71F3US Patent
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