Compile Data Set for Download or QSAR
Found 34 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein phosphatase non-receptor type 11 [205-593]'
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM25127((2E)-3-{3-chloro-4-[3-(3,3-dimethylbut-1-yn-1-yl)-...)copy SMILEScopy InChI
Affinity DataIC50: 450nMpH: 6.0 T: 2°CAssay Description:The phosphatase-catalyzed hydrolysis of 6,8-difluoro-4-methylumbelliferyl phosphate was assayed in the presence of each test compound. The fluorescen...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6GNQPubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM24533((3Z)-3-[2-(2-carboxyphenyl)hydrazin-1-ylidene]-2-o...)copy SMILEScopy InChI
Affinity DataIC50: 800nMpH: 7.0 T: 2°CAssay Description:PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD0ZZ8PubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM24548(3-{2-[(3Z)-5-{[(4-fluorophenyl)methyl]sulfamoyl}-2...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMpH: 7.0 T: 2°CAssay Description:PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD0ZZ8PubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM24541(4-{2-[(3Z)-5-(benzylsulfamoyl)-2-oxo-2,3-dihydro-1...)copy SMILEScopy InChI
Affinity DataIC50: 1.30E+3nMpH: 7.0 T: 2°CAssay Description:PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD0ZZ8PubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM24543(3-{2-[(3Z)-5-{[(4-chlorophenyl)methyl]sulfamoyl}-2...)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+3nMpH: 7.0 T: 2°CAssay Description:PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD0ZZ8PubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM25124((2E)-3-{4-[3-(adamantan-1-yl)-4-aminophenyl]-3-chl...)copy SMILEScopy InChI
Affinity DataIC50: 1.83E+3nMpH: 6.0 T: 2°CAssay Description:The phosphatase-catalyzed hydrolysis of 6,8-difluoro-4-methylumbelliferyl phosphate was assayed in the presence of each test compound. The fluorescen...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6GNQPubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM25122((2E)-3-{4-[3-(adamantan-1-yl)-4-hydroxyphenyl]-3-c...)copy SMILEScopy InChI
Affinity DataIC50: 2.10E+3nMpH: 6.0 T: 2°CAssay Description:The phosphatase-catalyzed hydrolysis of 6,8-difluoro-4-methylumbelliferyl phosphate was assayed in the presence of each test compound. The fluorescen...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6GNQPubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM25125((2E)-3-{4-[3-(adamantan-1-yl)-4-fluorophenyl]-3-ch...)copy SMILEScopy InChI
Affinity DataIC50: 2.11E+3nMpH: 6.0 T: 2°CAssay Description:The phosphatase-catalyzed hydrolysis of 6,8-difluoro-4-methylumbelliferyl phosphate was assayed in the presence of each test compound. The fluorescen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6GNQPubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM25131((2E)-3-{3-chloro-4-[3-(3,5-dimethyladamantan-1-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 2.27E+3nMpH: 6.0 T: 2°CAssay Description:The phosphatase-catalyzed hydrolysis of 6,8-difluoro-4-methylumbelliferyl phosphate was assayed in the presence of each test compound. The fluorescen...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6GNQPubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM24542(3-{2-[(3Z)-5-{[(3-chlorophenyl)methyl]sulfamoyl}-2...)copy SMILEScopy InChI
Affinity DataIC50: 3.80E+3nMpH: 7.0 T: 2°CAssay Description:PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD0ZZ8PubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM25129((2E)-3-[3-chloro-4-(4-hydroxy-3-{tricyclo[3.3.1.0^...)copy SMILEScopy InChI
Affinity DataIC50: 3.91E+3nMpH: 6.0 T: 2°CAssay Description:The phosphatase-catalyzed hydrolysis of 6,8-difluoro-4-methylumbelliferyl phosphate was assayed in the presence of each test compound. The fluorescen...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6GNQPubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM24539((3Z)-N-[(4-chlorophenyl)methyl]-3-[2-(2-nitropheny...)copy SMILEScopy InChI
Affinity DataIC50: 4.40E+3nMpH: 7.0 T: 2°CAssay Description:PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD0ZZ8PubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM24537(4-{2-[(3Z)-2-oxo-5-(propan-2-ylsulfamoyl)-2,3-dihy...)copy SMILEScopy InChI
Affinity DataIC50: 4.50E+3nMpH: 7.0 T: 2°CAssay Description:PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD0ZZ8PubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM24536(3-{2-[(3Z)-2-oxo-5-(propan-2-ylsulfamoyl)-2,3-dihy...)copy SMILEScopy InChI
Affinity DataIC50: 4.50E+3nMpH: 7.0 T: 2°CAssay Description:PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD0ZZ8PubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM25123((2E)-3-{4-[3-(adamantan-1-yl)-4-acetamidophenyl]-3...)copy SMILEScopy InChI
Affinity DataIC50: 4.55E+3nMpH: 6.0 T: 2°CAssay Description:The phosphatase-catalyzed hydrolysis of 6,8-difluoro-4-methylumbelliferyl phosphate was assayed in the presence of each test compound. The fluorescen...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6GNQPubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM24550(3-{2-[(3Z)-5-{[(3-chloro-4-fluorophenyl)methyl]sul...)copy SMILEScopy InChI
Affinity DataIC50: 4.80E+3nMpH: 7.0 T: 2°CAssay Description:PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD0ZZ8PubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM24540(3-{2-[(3Z)-5-{[(4-methylphenyl)methyl]sulfamoyl}-2...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMpH: 7.0 T: 2°CAssay Description:PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD0ZZ8PubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM24551(3-{2-[(3Z)-5-{[2-(2,4-dichlorophenyl)ethyl]sulfamo...)copy SMILEScopy InChI
Affinity DataIC50: 5.20E+3nMpH: 7.0 T: 2°CAssay Description:PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD0ZZ8PubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM25133((2E)-3-{3-chloro-4-[3-(3-ethylpentan-3-yl)-4-hydro...)copy SMILEScopy InChI
Affinity DataIC50: 5.37E+3nMpH: 6.0 T: 2°CAssay Description:The phosphatase-catalyzed hydrolysis of 6,8-difluoro-4-methylumbelliferyl phosphate was assayed in the presence of each test compound. The fluorescen...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6GNQPubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM24546(3-{2-[(3Z)-5-{[(2-chlorophenyl)methyl]sulfamoyl}-2...)copy SMILEScopy InChI
Affinity DataIC50: 5.50E+3nMpH: 7.0 T: 2°CAssay Description:PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD0ZZ8PubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM24544(4-{2-[(3Z)-5-{[(4-chlorophenyl)methyl]sulfamoyl}-2...)copy SMILEScopy InChI
Affinity DataIC50: 5.90E+3nMpH: 7.0 T: 2°CAssay Description:PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD0ZZ8PubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM24549(4-{2-[(3Z)-5-{[(4-fluorophenyl)methyl]sulfamoyl}-2...)copy SMILEScopy InChI
Affinity DataIC50: 6.30E+3nMpH: 7.0 T: 2°CAssay Description:PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD0ZZ8PubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM25130((2E)-3-{3-chloro-4-[4-hydroxy-3-(1-methylcyclohexy...)copy SMILEScopy InChI
Affinity DataIC50: 6.40E+3nMpH: 6.0 T: 2°CAssay Description:The phosphatase-catalyzed hydrolysis of 6,8-difluoro-4-methylumbelliferyl phosphate was assayed in the presence of each test compound. The fluorescen...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6GNQPubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM24545(4-{2-[(3Z)-5-{[(2-chlorophenyl)methyl]sulfamoyl}-2...)copy SMILEScopy InChI
Affinity DataIC50: 7.40E+3nMpH: 7.0 T: 2°CAssay Description:PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD0ZZ8PubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM24552(4-{2-[(3Z)-5-({[4-chloro-3-(trifluoromethyl)phenyl...)copy SMILEScopy InChI
Affinity DataIC50: 8.30E+3nMpH: 7.0 T: 2°CAssay Description:PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD0ZZ8PubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM25132((2E)-3-{3-chloro-4-[4-hydroxy-3-(2-methyl-1,3-dith...)copy SMILEScopy InChI
Affinity DataIC50: 1.02E+4nMpH: 6.0 T: 2°CAssay Description:The phosphatase-catalyzed hydrolysis of 6,8-difluoro-4-methylumbelliferyl phosphate was assayed in the presence of each test compound. The fluorescen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6GNQPubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM24553(3-{2-[(3Z)-5-({[4-chloro-3-(trifluoromethyl)phenyl...)copy SMILEScopy InChI
Affinity DataIC50: 1.06E+4nMpH: 7.0 T: 2°CAssay Description:PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD0ZZ8PubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM24538((3Z)-3-[2-(2-nitrophenyl)hydrazin-1-ylidene]-2-oxo...)copy SMILEScopy InChI
Affinity DataIC50: 1.19E+4nMpH: 7.0 T: 2°CAssay Description:PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD0ZZ8PubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM24534((3Z)-3-[2-(3-carboxyphenyl)hydrazin-1-ylidene]-2-o...)copy SMILEScopy InChI
Affinity DataIC50: 1.58E+4nMpH: 7.0 T: 2°CAssay Description:PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD0ZZ8PubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM25128((2E)-3-{3-chloro-4-[3-(2,6-dimethylphenyl)-4-hydro...)copy SMILEScopy InChI
Affinity DataIC50: 1.99E+4nMpH: 6.0 T: 2°CAssay Description:The phosphatase-catalyzed hydrolysis of 6,8-difluoro-4-methylumbelliferyl phosphate was assayed in the presence of each test compound. The fluorescen...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6GNQPubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM24535(3-{2-[(3Z)-5-{[(4-chlorophenyl)methyl]carbamoyl}-2...)copy SMILEScopy InChI
Affinity DataIC50: 2.23E+4nMpH: 7.0 T: 2°CAssay Description:PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD0ZZ8PubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM24547(2-{2-[(3Z)-5-({[4-chloro-3-(trifluoromethyl)phenyl...)copy SMILEScopy InChI
Affinity DataIC50: 2.29E+4nMpH: 7.0 T: 2°CAssay Description:PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD0ZZ8PubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM24531((3Z)-3-[2-(2-nitrophenyl)hydrazin-1-ylidene]-2-oxo...)copy SMILEScopy InChI
Affinity DataIC50: 4.68E+4nMpH: 7.0 T: 2°CAssay Description:PTP activity was measured in a black 96-well plate. Reaction was initiated by addition of the substrate DiFMUP to enzyme mixtures containing test com...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD0ZZ8PubMed
TargetTyrosine-protein phosphatase non-receptor type 11 [205-593](Homo sapiens (Human))
Burnham Institute for Medical Research

LigandPNGBDBM25126((2E)-3-[3-chloro-4-(4-fluorophenyl)phenyl]prop-2-e...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+5nMpH: 6.0 T: 2°CAssay Description:The phosphatase-catalyzed hydrolysis of 6,8-difluoro-4-methylumbelliferyl phosphate was assayed in the presence of each test compound. The fluorescen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24T6GNQPubMed