Compile Data Set for Download or QSAR
Found 65 Enz. Inhib. hit(s) with Target = 'A disintegrin and metalloproteinase with thrombospondin motifs 5 [262-930,L692P]'
LigandPNGBDBM28339((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(7H-purin...)copy SMILEScopy InChI
Affinity DataIC50: 71nMAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HPWPubMed
LigandPNGBDBM28337((1R,2S)-1-{[4-(4-chlorophenyl)benzene]({2-[4-(meth...)copy SMILEScopy InChI
Affinity DataIC50: 73nMAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HPWPubMed
LigandPNGBDBM28327((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(3-methox...)copy SMILEScopy InChI
Affinity DataIC50: 78nMpH: 7.5 T: 2°CAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HPWPubMed
LigandPNGBDBM28340((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(9H-purin...)copy SMILEScopy InChI
Affinity DataIC50: 170nMAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HPWPubMed
LigandPNGBDBM28326((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(2-oxo-1,...)copy SMILEScopy InChI
Affinity DataIC50: 180nMpH: 7.5 T: 2°CAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HPWPubMed
LigandPNGBDBM28332((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(1H-1,2,4...)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HPWPubMed
LigandPNGBDBM28333((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(4H-1,2,4...)copy SMILEScopy InChI
Affinity DataIC50: 190nMAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HPWPubMed
LigandPNGBDBM28314((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(2-oxopyr...)copy SMILEScopy InChI
Affinity DataIC50: 200nMpH: 7.5 T: 2°CAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HPWPubMed
LigandPNGBDBM28325((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(2-oxopip...)copy SMILEScopy InChI
Affinity DataIC50: 210nMpH: 7.5 T: 2°CAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HPWPubMed
LigandPNGBDBM28324((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(2-oxo-1,...)copy SMILEScopy InChI
Affinity DataIC50: 220nMpH: 7.5 T: 2°CAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HPWPubMed
LigandPNGBDBM28338((1R,2S)-1-{[4-(4-chlorophenyl)benzene]({2-[5-(meth...)copy SMILEScopy InChI
Affinity DataIC50: 230nMAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HPWPubMed
LigandPNGBDBM28334((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(2H-1,2,3...)copy SMILEScopy InChI
Affinity DataIC50: 260nMAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HPWPubMed
LigandPNGBDBM28336((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(1H-1,2,3...)copy SMILEScopy InChI
Affinity DataIC50: 270nMAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HPWPubMed
LigandPNGBDBM28335((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(1H-1,2,3...)copy SMILEScopy InChI
Affinity DataIC50: 270nMAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HPWPubMed
LigandPNGBDBM28329((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(pyridin-...)copy SMILEScopy InChI
Affinity DataIC50: 290nMAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HPWPubMed
LigandPNGBDBM28323((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(2,5-diox...)copy SMILEScopy InChI
Affinity DataIC50: 310nMpH: 7.5 T: 2°CAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HPWPubMed
LigandPNGBDBM28331((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(1H-imida...)copy SMILEScopy InChI
Affinity DataIC50: 320nMAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HPWPubMed
LigandPNGBDBM24019(1-benzyl-5-methyl-5'-(4-methylphenyl)-1,2-dihydro-...)copy SMILEScopy InChI
Affinity DataIC50: 610nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H993G9PubMed
LigandPNGBDBM24008(1-benzyl-5'-(4-methoxyphenyl)-5-methyl-1,2-dihydro...)copy SMILEScopy InChI
Affinity DataIC50: 640nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H993G9PubMed
LigandPNGBDBM28328((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(pyridin-...)copy SMILEScopy InChI
Affinity DataIC50: 750nMpH: 7.5 T: 2°CAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HPWPubMed
LigandPNGBDBM24006(5'-(4-methoxyphenyl)-6-propyl-1,2-dihydro-3'H-spir...)copy SMILEScopy InChI
Affinity DataIC50: 780nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H993G9PubMed
LigandPNGBDBM28330((1R,2S)-1-{[4-(4-chlorophenyl)benzene][2-(pyridin-...)copy SMILEScopy InChI
Affinity DataIC50: 820nMAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HPWPubMed
LigandPNGBDBM24007(1-benzyl-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spir...)copy SMILEScopy InChI
Affinity DataIC50: 870nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H993G9PubMed
LigandPNGBDBM28316((1R,2S)-1-({[4-(4-chlorophenyl)-1,2,3,6-tetrahydro...)copy SMILEScopy InChI
Affinity DataIC50: 880nMpH: 7.5 T: 2°CAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HPWPubMed
LigandPNGBDBM24009(5'-(4-methoxyphenyl)-5-methyl-1-(2-methylphenyl)-1...)copy SMILEScopy InChI
Affinity DataIC50: 900nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H993G9PubMed
LigandPNGBDBM24022(1-benzyl-5'-(4-methoxyphenyl)-5-methyl-6-propyl-1,...)copy SMILEScopy InChI
Affinity DataIC50: 950nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H993G9PubMed
LigandPNGBDBM28317((1R,2S)-1-{[6-(4-chlorophenyl)pyridine-3-][2-(2-ox...)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+3nMpH: 7.5 T: 2°CAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HPWPubMed
LigandPNGBDBM24018(5-methyl-1-(2-methylphenyl)-5'-(4-methylphenyl)-1,...)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H993G9PubMed
LigandPNGBDBM24013(6-chloro-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spir...)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H993G9PubMed
LigandPNGBDBM24012(5'-(4-methoxyphenyl)-6-methyl-1,2-dihydro-3'H-spir...)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H993G9PubMed
LigandPNGBDBM24004(5-ethyl-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spiro...)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H993G9PubMed
LigandPNGBDBM24001(5'-(4-methylphenyl)-6-propyl-1,2-dihydro-3'H-spiro...)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H993G9PubMed
LigandPNGBDBM24021(1-(4-chlorophenyl)-5'-(4-methoxyphenyl)-5-methyl-1...)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H993G9PubMed
LigandPNGBDBM28313((2R)-2-{[4-(4-chlorophenyl)benzene][2-(2-oxopyrrol...)copy SMILEScopy InChI
Affinity DataIC50: 1.60E+3nMpH: 7.5 T: 2°CAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HPWPubMed
LigandPNGBDBM24000(5-ethyl-5'-(4-methylphenyl)-1,2-dihydro-3'H-spiro[...)copy SMILEScopy InChI
Affinity DataIC50: 1.90E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H993G9PubMed
LigandPNGBDBM24005(5-chloro-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spir...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H993G9PubMed
LigandPNGBDBM24010(5-bromo-5'-(4-methoxyphenyl)-1,2-dihydro-3'H-spiro...)copy SMILEScopy InChI
Affinity DataIC50: 2.40E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H993G9PubMed
LigandPNGBDBM24003(5'-(4-methoxyphenyl)-5-methyl-1,2-dihydro-3'H-spir...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H993G9PubMed
LigandPNGBDBM24016(1,5'-diphenyl-1,2-dihydro-3'H-spiro[indole-3,2'-[1...)copy SMILEScopy InChI
Affinity DataIC50: 2.60E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H993G9PubMed
LigandPNGBDBM23999(5-methyl-5'-(4-methylphenyl)-1,2-dihydro-3'H-spiro...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H993G9PubMed
LigandPNGBDBM24015(5'-phenyl-1-(propan-2-yl)-1,2-dihydro-3'H-spiro[in...)copy SMILEScopy InChI
Affinity DataIC50: 3.10E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H993G9PubMed
LigandPNGBDBM28306((2R)-2-{[4-(4-chlorophenyl)benzene]sulfonamido}-3-...)copy SMILEScopy InChI
Affinity DataIC50: 3.20E+3nMpH: 7.5 T: 2°CAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HPWPubMed
LigandPNGBDBM23998(5'-(4-methylphenyl)-1,2-dihydro-3'H-spiro[indole-3...)copy SMILEScopy InChI
Affinity DataIC50: 3.70E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H993G9PubMed
LigandPNGBDBM24011(5'-(4-methoxyphenyl)-5-nitro-1,2-dihydro-3'H-spiro...)copy SMILEScopy InChI
Affinity DataIC50: 4.40E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H993G9PubMed
LigandPNGBDBM28319((1R,2S)-1-{[4-(4-acetamidophenyl)benzene][2-(2-oxo...)copy SMILEScopy InChI
Affinity DataIC50: 4.50E+3nMpH: 7.5 T: 2°CAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HPWPubMed
LigandPNGBDBM24017(1-methyl-5'-(4-methylphenyl)-1,2-dihydro-3'H-spiro...)copy SMILEScopy InChI
Affinity DataIC50: 4.60E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H993G9PubMed
LigandPNGBDBM28318((1R,2S)-1-({4-[4-(dimethylamino)phenyl]benzene}[2-...)copy SMILEScopy InChI
Affinity DataIC50: 6.60E+3nMpH: 7.5 T: 2°CAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HPWPubMed
LigandPNGBDBM23997(5'-phenyl-5-(trifluoromethoxy)-1,2-dihydro-3'H-spi...)copy SMILEScopy InChI
Affinity DataIC50: 7.20E+3nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H993G9PubMed
LigandPNGBDBM28312((2R)-2-{[4-(4-chlorophenyl)benzene](2-phenylethyl)...)copy SMILEScopy InChI
Affinity DataIC50: 7.30E+3nMpH: 7.5 T: 2°CAssay Description:The ADAMTS-5 (Aggrecanase-2) assay was performed using fluorescent peptide substrate WAAG-3R and the recombinant Agg-2 pre-incubated with various con...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HPWPubMed
LigandPNGBDBM24020(5'-(4-methoxyphenyl)-1-methyl-1,2-dihydro-3'H-spir...)copy SMILEScopy InChI
Affinity DataIC50: 7.50E+3nMAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H993G9PubMed
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