Compile Data Set for Download or QSAR
Found 19 Enz. Inhib. hit(s) with Target = 'AMP deaminase 1'
TargetAMP deaminase 1(Oryctolagus cuniculus)
AgrEvo UK Limited

Curated by ChEMBL
LigandPNGBDBM50004699(CHEBI:45262 | CHEMBL96862 | US11185100, TABLE 9.3)copy SMILEScopy InChI
Affinity DataKi:  6.50E+3nMAssay Description:Inhibition of Oryctolagus cuniculus (rabbit) muscle adenylate deaminaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WQ0591PubMed
TargetAMP deaminase 1(Homo sapiens (Human))
Metabasis Therapeutics Inc.

Curated by ChEMBL
LigandPNGBDBM50087313(8-(8-Hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]dia...)copy SMILEScopy InChI
Affinity DataKi:  8.00E+3nMAssay Description:Evaluated for the inhibition of porcine heart or human L-type Adenosine 5'-monophosphate deaminase (AMPDA)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z31XWJPubMed
TargetAMP deaminase 1(Homo sapiens (Human))
Metabasis Therapeutics Inc.

Curated by ChEMBL
LigandPNGBDBM50087307(3-Heptyl-3,6,7,8-tetrahydro-imidazo[4,5-d][1,3]dia...)copy SMILEScopy InChI
Affinity DataKi:  1.00E+4nMAssay Description:Evaluated for the inhibition of porcine heart or human L-type Adenosine 5'-monophosphate deaminase (AMPDA)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z31XWJPubMed
TargetAMP deaminase 1(Homo sapiens (Human))
Metabasis Therapeutics Inc.

Curated by ChEMBL
LigandPNGBDBM50087317(3-Octyl-3,6,7,8-tetrahydro-imidazo[4,5-d][1,3]diaz...)copy SMILEScopy InChI
Affinity DataKi:  1.80E+4nMAssay Description:Evaluated for the inhibition of porcine heart or human L-type Adenosine 5'-monophosphate deaminase (AMPDA)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z31XWJPubMed
TargetAMP deaminase 1(Homo sapiens (Human))
Metabasis Therapeutics Inc.

Curated by ChEMBL
LigandPNGBDBM50087311(8-(8-Hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]dia...)copy SMILEScopy InChI
Affinity DataKi:  2.00E+4nMAssay Description:Evaluated for the inhibition of porcine heart or human L-type Adenosine 5'-monophosphate deaminase (AMPDA)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z31XWJPubMed
TargetAMP deaminase 1(Homo sapiens (Human))
Metabasis Therapeutics Inc.

Curated by ChEMBL
LigandPNGBDBM50087301(CHEMBL290418 | Sodium; 4-(8-hydroxy-7,8-dihydro-6H...)copy SMILEScopy InChI
Affinity DataKi:  8.50E+4nMAssay Description:Evaluated for the inhibition of porcine heart or human L-type Adenosine 5'-monophosphate deaminase (AMPDA)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z31XWJPubMed
TargetAMP deaminase 1(Homo sapiens (Human))
Metabasis Therapeutics Inc.

Curated by ChEMBL
LigandPNGBDBM50087303(7-(8-Hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]dia...)copy SMILEScopy InChI
Affinity DataKi:  1.70E+5nMAssay Description:Evaluated for the inhibition of porcine heart or human L-type Adenosine 5'-monophosphate deaminase (AMPDA)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z31XWJPubMed
TargetAMP deaminase 1(Rattus norvegicus (Rat))
AstraZeneca R&D

LigandPNGBDBM154584(4-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methy...)copy SMILEScopy InChI
Affinity DataIC50: 20nMpH: 7.4Assay Description:AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M0445MPubMed
TargetAMP deaminase 1(Mus musculus (Mouse))
AstraZeneca R&D

LigandPNGBDBM154584(4-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methy...)copy SMILEScopy InChI
Affinity DataIC50: 20nMpH: 7.4Assay Description:AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M0445MPubMed
TargetAMP deaminase 1(Mus musculus (Mouse))
AstraZeneca R&D

LigandPNGBDBM154583(6-[4-({[(1S)-1-(isoquinolin-8-yl)ethyl]amino}methy...)copy SMILEScopy InChI
Affinity DataIC50: 24nMpH: 7.4Assay Description:AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M0445MPubMed
TargetAMP deaminase 1(Homo sapiens (Human))
Metabasis Therapeutics Inc.

Curated by ChEMBL
LigandPNGBDBM154584(4-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methy...)copy SMILEScopy InChI
Affinity DataIC50: 24nMpH: 7.4Assay Description:AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M0445MPubMed
TargetAMP deaminase 1(Rattus norvegicus (Rat))
AstraZeneca R&D

LigandPNGBDBM154583(6-[4-({[(1S)-1-(isoquinolin-8-yl)ethyl]amino}methy...)copy SMILEScopy InChI
Affinity DataIC50: 27nMpH: 7.4Assay Description:AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M0445MPubMed
TargetAMP deaminase 1(Homo sapiens (Human))
Metabasis Therapeutics Inc.

Curated by ChEMBL
LigandPNGBDBM154583(6-[4-({[(1S)-1-(isoquinolin-8-yl)ethyl]amino}methy...)copy SMILEScopy InChI
Affinity DataIC50: 38nMpH: 7.4Assay Description:AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M0445MPubMed
TargetAMP deaminase 1(Oryctolagus cuniculus)
AgrEvo UK Limited

Curated by ChEMBL
LigandPNGBDBM50004698(CHEMBL1160282)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Inhibition of Oryctolagus cuniculus (rabbit) muscle adenylate deaminaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WQ0591PubMed
TargetAMP deaminase 1(Homo sapiens (Human))
Metabasis Therapeutics Inc.

Curated by ChEMBL
LigandPNGBDBM50096172(1-Bromo-4-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5...)copy SMILEScopy InChI
Affinity DataIC50: 500nMAssay Description:Inhibition of human skeletal muscle AMPD1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X0683XPubMed
TargetAMP deaminase 1(Homo sapiens (Human))
Metabasis Therapeutics Inc.

Curated by ChEMBL
LigandPNGBDBM154581(6-[4-({[(1R)-1-(naphthalen-1-yl)ethyl]amino}methyl...)copy SMILEScopy InChI
Affinity DataIC50: 620nMpH: 7.4Assay Description:AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M0445MPubMed
TargetAMP deaminase 1(Mus musculus (Mouse))
AstraZeneca R&D

LigandPNGBDBM154582(6-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methy...)copy SMILEScopy InChI
Affinity DataIC50: 4.50E+3nMpH: 7.4Assay Description:AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M0445MPubMed
TargetAMP deaminase 1(Rattus norvegicus (Rat))
AstraZeneca R&D

LigandPNGBDBM154582(6-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methy...)copy SMILEScopy InChI
Affinity DataIC50: 5.80E+3nMpH: 7.4Assay Description:AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M0445MPubMed
TargetAMP deaminase 1(Homo sapiens (Human))
Metabasis Therapeutics Inc.

Curated by ChEMBL
LigandPNGBDBM154582(6-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methy...)copy SMILEScopy InChI
Affinity DataIC50: 9.20E+3nMpH: 7.4Assay Description:AMPD1 was added to buffer A (50 mM HEPES, 150 mM KCl, 5 mM MgCl2, and 0.5 mMglutathione [pH 7.4]) to a concentration of 10 nM. A substrate mix consis...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M0445MPubMed