Compile Data Set for Download or QSAR
Found 208 Enz. Inhib. hit(s) with Target = 'Aldo-keto reductase family 1 member C4'
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50219490(3-Bromo-5-phenylsalicylc acid | 5-bromo-4-hydroxyb...)copy SMILEScopy InChI
Affinity DataKi:  1.82E+4nMAssay Description:Inhibition of human recombinant type 1 3-alpha-HSD expressed in Escherichia coli JM109More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2765F6TPubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM26269(3,5-dichloro-2-hydroxybenzoic acid | 3,5-dichloros...)copy SMILEScopy InChI
Affinity DataKi:  2.40E+4nM ΔG°:  -26.4kJ/molepH: 7.4 T: 2°CAssay Description:The activity was assayed by measuring the rate of change in NADPH fluorescence (at 455 nm with an excitation wavelength of 340 nm) at 298 K. When the...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MG7MTWPubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50396691(CHEMBL449572 | US9271961, Jasmonic acid)copy SMILEScopy InChI
Affinity DataKi:  3.70E+4nMAssay Description:Inhibition of human recombinant AKR1C4 expressed in Escherichia coli BL21(DE3) using phenanthrenequinone as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28K7B6FPubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50249792(3,5-Dibromosalicylic acid | CHEMBL447448)copy SMILEScopy InChI
Affinity DataKi:  4.57E+4nMAssay Description:Inhibition of human recombinant type 1 3-alpha-HSD expressed in Escherichia coli JM109More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2765F6TPubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50427622(CHEMBL2323508 | US9346803, Table 2, Compound 10: 3...)copy SMILEScopy InChI
Affinity DataIC50: 1.95nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154FXNUS Patent
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50427624(CHEMBL2323522 | US9346803, Table 2, Compound 11: 9...)copy SMILEScopy InChI
Affinity DataIC50: 3.15nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154FXNUS Patent
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50427620(CHEMBL2323507 | US9346803, 2)copy SMILEScopy InChI
Affinity DataIC50: 3.51nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154FXNUS Patent
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50427619(CHEMBL2323511 | US9346803, 3)copy SMILEScopy InChI
Affinity DataIC50: 12.6nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154FXNUS Patent
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50293598(2'-des-methyl indomethacin | CHEMBL503179 | US9346...)copy SMILEScopy InChI
Affinity DataIC50: 48.7nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154FXNUS Patent
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50427628(CHEMBL2323472 | US9346803, Table 2, Compound 8: 2-...)copy SMILEScopy InChI
Affinity DataIC50: 49.8nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154FXNUS Patent
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50427626(CHEMBL2323481 | US9346803, Table 2, Compound 5: 2-...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154FXNUS Patent
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50427625(CHEMBL178687 | US9346803, Table 2, Compound 6: 3-[...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154FXNUS Patent
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50427629(CHEMBL179587 | US9346803, Table 2, Compound 7: 2-[...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154FXNUS Patent
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50427621(CHEMBL2323490 | US9346803, 1)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154FXNUS Patent
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50427627(CHEMBL2323474 | US9346803, Table 2, Compound 9: 2-...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibitors were initially screened for an ability to block the NADP+ dependent oxidation of the artificial substrate S-tetralol catalyzed by AKR1C3. ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154FXNUS Patent
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50241828(CHEMBL4089817)copy SMILEScopy InChI
Affinity DataIC50: 350nMAssay Description:Inhibition of recombinant human AKR1C4 using S-tetralol as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ89S7PubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50595596(CHEMBL5203670)copy SMILES
Affinity DataIC50: 360nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB85WJPubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50595592(CHEMBL5179823)copy SMILES
Affinity DataIC50: 750nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB85WJPubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50241817(CHEMBL4081954)copy SMILEScopy InChI
Affinity DataIC50: 820nMAssay Description:Inhibition of recombinant human AKR1C4 using S-tetralol as substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ89S7PubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50427622(CHEMBL2323508 | US9346803, Table 2, Compound 10: 3...)copy SMILEScopy InChI
Affinity DataIC50: 1.95E+3nMAssay Description:Inhibition of human recombinant AKR1C4-mediated NADP+-dependent oxidation of S-(+)-1,2,3,4-tetrahydro-1-naphtholMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92CMGPubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50029207((E)-3-(3,4-Dihydroxy-phenyl)-acrylic acid phenethy...)copy SMILEScopy InChI
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human recombinant GST-tagged AKR1C4 expressed in Escherichia coli using S-tetralol as substrate by fluorometryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z320P2PubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50396689(CHEMBL2172077)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human recombinant N-terminal His6-tagged AKR1C4 expressed in Escherichia coli BL21(DE3) cells using 8-Acetyl-2,3,5,6-tetrahydro-1H,4H-1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28K7B6FPubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50427624(CHEMBL2323522 | US9346803, Table 2, Compound 11: 9...)copy SMILEScopy InChI
Affinity DataIC50: 3.15E+3nMAssay Description:Inhibition of human recombinant AKR1C4-mediated NADP+-dependent oxidation of S-(+)-1,2,3,4-tetrahydro-1-naphtholMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92CMGPubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50427620(CHEMBL2323507 | US9346803, 2)copy SMILEScopy InChI
Affinity DataIC50: 3.51E+3nMAssay Description:Inhibition of human recombinant AKR1C4-mediated NADP+-dependent oxidation of S-(+)-1,2,3,4-tetrahydro-1-naphtholMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92CMGPubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50240376(3,4,5-Trihydroxy-benzoic acid octyl ester | CHEMBL...)copy SMILEScopy InChI
Affinity DataIC50: 4.04E+3nMAssay Description:Inhibition of N-terminal His-tagged human AKR1C4 expressed in Escherichia coli BL21 (Condon Plus) competent cells using 9,10 -Phenanthrenequinone as ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B63QXPubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50546234(CHEMBL4758386)copy SMILES
Affinity DataIC50: 5.34E+3nMAssay Description:Inhibition of human AKR1C4 using S-tetralol as substrate in presence of NADP by fluorescence methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B63QXPubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM220123(US9271961, BMT 5-119)copy SMILEScopy InChI
Affinity DataIC50: 5.50E+3nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27W6B22US Patent
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50385687(CHEMBL2041555)copy SMILEScopy InChI
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of recombinant AKR1C4 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XGPPubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM220115(US9271961, 13)copy SMILEScopy InChI
Affinity DataIC50: 8.17E+3nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27W6B22US Patent
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50382163(CHEMBL2023820)copy SMILEScopy InChI
Affinity DataIC50: 8.17E+3nMAssay Description:Inhibition of recombinant AKR1C4 assessed as enzyme catalyzed oxidation of S-tetralol by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24M95JQPubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50029207((E)-3-(3,4-Dihydroxy-phenyl)-acrylic acid phenethy...)copy SMILEScopy InChI
Affinity DataIC50: 8.25E+3nMAssay Description:Inhibition of N-terminal His-tagged human AKR1C4 expressed in Escherichia coli BL21 (Condon Plus) competent cells using 9,10 -Phenanthrenequinone as ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B63QXPubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50396647(CHEMBL2172083)copy SMILEScopy InChI
Affinity DataIC50: 9.81E+3nMAssay Description:Inhibition of human recombinant N-terminal His6-tagged AKR1C4 expressed in Escherichia coli BL21(DE3) cells using 8-Acetyl-2,3,5,6-tetrahydro-1H,4H-1...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28K7B6FPubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50543397(CHEMBL4646593)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant AKR1C4 (unknown origin) assessed as reduction in S-tetralol-induced dehydrogenase activity by measuring NADPH levelMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40ZSNPubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50543401(CHEMBL4644092)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant AKR1C4 (unknown origin) assessed as reduction in S-tetralol-induced dehydrogenase activity by measuring NADPH levelMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40ZSNPubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50543402(CHEMBL4634960)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant AKR1C4 (unknown origin) assessed as reduction in S-tetralol-induced dehydrogenase activity by measuring NADPH levelMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40ZSNPubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50543400(CHEMBL4640248)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant AKR1C4 (unknown origin) assessed as reduction in S-tetralol-induced dehydrogenase activity by measuring NADPH levelMore data for this Ligand-Target Pair
Ligand InfoMCE
PC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40ZSNPubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50543405(CHEMBL4639417)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant AKR1C4 (unknown origin) assessed as reduction in S-tetralol-induced dehydrogenase activity by measuring NADPH levelMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40ZSNPubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50543399(CHEMBL4648793)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant AKR1C4 (unknown origin) assessed as reduction in S-tetralol-induced dehydrogenase activity by measuring NADPH levelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40ZSNPubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50543404(CHEMBL4640154)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant AKR1C4 (unknown origin) assessed as reduction in S-tetralol-induced dehydrogenase activity by measuring NADPH levelMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40ZSNPubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50427619(CHEMBL2323511 | US9346803, 3)copy SMILEScopy InChI
Affinity DataIC50: 1.26E+4nMAssay Description:Inhibition of human recombinant AKR1C4-mediated NADP+-dependent oxidation of S-(+)-1,2,3,4-tetrahydro-1-naphtholMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92CMGPubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50509728(CHEMBL4545749)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of recombinant human AKR1C4 expressed in Escherichia coli BL21 (D3) using S-tetralol as substrate in presence of NADP+ by UV-spectrophotom...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QF8X52PubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50546235(CHEMBL4795494)copy SMILES
Affinity DataIC50: 1.77E+4nMAssay Description:Inhibition of human AKR1C4 using S-tetralol as substrate in presence of NADP by fluorescence methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B63QXPubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50024764(CHEMBL3337721)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of AKR1C4 (unknown origin) assessed as dehydrogenase activity of enzyme by NADPH fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28P623FPubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50390657(CHEMBL2070002)copy SMILEScopy InChI
Affinity DataIC50: 2.01E+4nMAssay Description:Inhibition of recombinant AKR1C4 using S-tetralol as substrate by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DFRPubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM220124(US9271961, BMT 4-90)copy SMILEScopy InChI
Affinity DataIC50: 2.04E+4nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27W6B22US Patent
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50385688(CHEMBL2041556)copy SMILEScopy InChI
Affinity DataIC50: 2.04E+4nMAssay Description:Inhibition of recombinant AKR1C4 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XGPPubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50384946(CHEMBL511708)copy SMILEScopy InChI
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of recombinant human AKR1C4 expressed in Escherichia coli BL21 (D3) using S-tetralol as substrate in presence of NADP+ by UV-spectrophotom...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QF8X52PubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50337282(3-[N-(4-acetylphenyl)amino]benzoic acid | CHEMBL16...)copy SMILEScopy InChI
Affinity DataIC50: 2.57E+4nMAssay Description:Inhibition of recombinant AKR1C4 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XGPPubMed
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50337282(3-[N-(4-acetylphenyl)amino]benzoic acid | CHEMBL16...)copy SMILEScopy InChI
Affinity DataIC50: 2.57E+4nMAssay Description:Compounds may be evaluated as selective reversible inhibitors of AKR1C3 by screening them against homogeneous recombinant AKR1C1-AKR1C4 expressed in ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27W6B22US Patent
TargetAldo-keto reductase family 1 member C4(Homo sapiens (Human))
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50385686(CHEMBL2041554)copy SMILEScopy InChI
Affinity DataIC50: 2.87E+4nMAssay Description:Inhibition of recombinant AKR1C4 assessed as NADP+ dependent oxidation of S-tetralol by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XGPPubMed
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