Compile Data Set for Download or QSAR
Found 439 Enz. Inhib. hit(s) with Target = 'Beta-adrenergic receptor kinase 1'
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50049820(4-Amino-5-carboxamide-7-(D-ribofuranosyl)pyrrolo[2...)copy SMILEScopy InChI
Affinity DataKi:  6.70E+4nMAssay Description:Inhibition of beta-adrenergic receptor kinase(unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD11FRPubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50173313(CHEMBL1738878)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257447(CHEMBL4073882)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged GRK2 expressed in baculovirus expression system using ulight topo2alpha as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q280552ZPubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257340(CHEMBL4072828)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q280552ZPubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257343(CHEMBL4086046)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q280552ZPubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257445(CHEMBL4095659)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q280552ZPubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257426(CHEMBL4077447)copy SMILEScopy InChI
Affinity DataIC50: 3.90nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged GRK2 expressed in baculovirus expression system using ulight topo2alpha as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q280552ZPubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257330(CHEMBL4071398)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged GRK2 expressed in baculovirus expression system using ulight topo2alpha as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q280552ZPubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50554257(CHEMBL4742990)copy SMILES
Affinity DataIC50: 6nMAssay Description:Inhibition of human GRK2 by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H135PSPubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257328(CHEMBL4082775)copy SMILEScopy InChI
Affinity DataIC50: 6.10nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q280552ZPubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257342(CHEMBL4103972)copy SMILEScopy InChI
Affinity DataIC50: 6.80nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged GRK2 expressed in baculovirus expression system using ulight topo2alpha as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q280552ZPubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257365(CHEMBL4083276)copy SMILEScopy InChI
Affinity DataIC50: 7.5nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q280552ZPubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257341(CHEMBL4094447)copy SMILEScopy InChI
Affinity DataIC50: 7.80nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q280552ZPubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50554266(CHEMBL4785990)copy SMILES
Affinity DataIC50: 9nMAssay Description:Inhibition of human GRK2 by transcreener assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H135PSPubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257344(CHEMBL4065690)copy SMILEScopy InChI
Affinity DataIC50: 9.90nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q280552ZPubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50554268(CHEMBL4745381)copy SMILES
Affinity DataIC50: 10nMAssay Description:Inhibition of human GRK2 by transcreener assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H135PSPubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50554267(CHEMBL4760734)copy SMILES
Affinity DataIC50: 10nMAssay Description:Inhibition of human GRK2 by transcreener assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H135PSPubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50540741(CHEMBL4640019)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of human GRK2 in presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2930XQ1PubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50554276(CHEMBL4753687)copy SMILES
Affinity DataIC50: 12nMAssay Description:Inhibition of human GRK2 by transcreener assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H135PSPubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257389(CHEMBL4093075)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q280552ZPubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257425(CHEMBL4060973)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q280552ZPubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257429(CHEMBL4061438)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q280552ZPubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50554274(CHEMBL4782910)copy SMILES
Affinity DataIC50: 13nMAssay Description:Inhibition of human GRK2 by transcreener assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H135PSPubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM258598(US9493490, Example 10 | US9493490, G)copy SMILEScopy InChI
Affinity DataIC50: 13.9nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R2109JUS Patent
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257366(CHEMBL4082559)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q280552ZPubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257409(CHEMBL4087117)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q280552ZPubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257329(CHEMBL4064232)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q280552ZPubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257424(CHEMBL4082853)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q280552ZPubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257350(CHEMBL1738877)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50554272(CHEMBL4751285)copy SMILES
Affinity DataIC50: 18nMAssay Description:Inhibition of human GRK2 by transcreener assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H135PSPubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257390(CHEMBL4082805)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q280552ZPubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50554258(CHEMBL4744858)copy SMILES
Affinity DataIC50: 19nMAssay Description:Inhibition of human GRK2 by transcreener assayMore data for this Ligand-Target Pair
Ligand InfoMCE
PC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H135PSPubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257369(CHEMBL4082713)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q280552ZPubMed
TargetBeta-adrenergic receptor kinase 1(Bos taurus)
Department of Medicinal Chemistry, College of Pharmacy,?Departments of Pharmacology and Biological Chemistry, Life Sciences Institute,§Ph.D. Program in Chemical Biology,?Vahlteich Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50173313(CHEMBL1738878)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of bovine GRK2 S670A mutant after 5 mins in presence of ATP by phosphorimaging assayMore data for this Ligand-Target Pair
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM258596(US9493490, 6-(4-(1-aminoethyl)-2-fluorophenoxy)-7-...)copy SMILEScopy InChI
Affinity DataIC50: 20nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R2109JUS Patent
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50173313(CHEMBL1738878)copy SMILEScopy InChI
Affinity DataIC50: 20nMMore data for this Ligand-Target Pair
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM258595(US9493490, 6-(4-(aminomethyl)-2-fluorophenoxy)-7-m...)copy SMILEScopy InChI
Affinity DataIC50: 20nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R2109JUS Patent
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM258597(US9493490, Example 9 | US9493490, F)copy SMILEScopy InChI
Affinity DataIC50: 20nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R2109JUS Patent
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50173313(CHEMBL1738878)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of GRK2 (unknown origin)More data for this Ligand-Target Pair
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM258594(US9493490, 6-(4-(1-aminoethyl)-2-fluorophenoxy)ben...)copy SMILEScopy InChI
Affinity DataIC50: 20nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R2109JUS Patent
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257503(CHEMBL4067877)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q280552ZPubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257387(CHEMBL4075063)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q280552ZPubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257410(CHEMBL4089087)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibition of human GRK2 expressed in HEK-B2 cells assessed as isoproterenol-stimulated cAMP accumulation preincubation for 20 mins followed by isopr...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q280552ZPubMed
TargetBeta-adrenergic receptor kinase 1(Bos taurus)
Department of Medicinal Chemistry, College of Pharmacy,?Departments of Pharmacology and Biological Chemistry, Life Sciences Institute,§Ph.D. Program in Chemical Biology,?Vahlteich Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50260140(CHEMBL4090144)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of bovine GRK2 S670A mutant after 5 mins in presence of ATP by phosphorimaging assayMore data for this Ligand-Target Pair
TargetBeta-adrenergic receptor kinase 1(Bos taurus)
Department of Medicinal Chemistry, College of Pharmacy,?Departments of Pharmacology and Biological Chemistry, Life Sciences Institute,§Ph.D. Program in Chemical Biology,?Vahlteich Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50257350(CHEMBL1738877)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of bovine GRK2 S670A mutant after 5 mins in presence of ATP by phosphorimaging assayMore data for this Ligand-Target Pair
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM258600(US9493490, 6-(3-(aminomethyl)-2-fluorophenoxy)-7-m...)copy SMILEScopy InChI
Affinity DataIC50: 30nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R2109JUS Patent
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257350(CHEMBL1738877)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of GRK2 (unknown origin)More data for this Ligand-Target Pair
TargetBeta-adrenergic receptor kinase 1(Bos taurus)
Department of Medicinal Chemistry, College of Pharmacy,?Departments of Pharmacology and Biological Chemistry, Life Sciences Institute,§Ph.D. Program in Chemical Biology,?Vahlteich Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50260141(CHEMBL4097393)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of bovine GRK2 S670A mutant after 5 mins in presence of ATP by phosphorimaging assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M047XQPubMed
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM258599(US9493490, Example 11 | US9493490, L | US9493490, ...)copy SMILEScopy InChI
Affinity DataIC50: 30nMT: 2°CAssay Description:Phosphorylation of activity of ROCK1 and ROCK2 and those of other kinases, AKT1, GRK2, PKA, PKCa and RSK1 were performed by Reaction Biology (Malvern...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R2109JUS Patent
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50257430(CHEMBL4070100)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged GRK2 expressed in baculovirus expression system using ulight topo2alpha as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q280552ZPubMed
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