Compile Data Set for Download or QSAR
Found 638 Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform'
LigandPNGBDBM50579637(CHEMBL4878958)copy SMILES
Affinity DataKi:  0.310nMAssay Description:Inhibition of human PI3K p110beta/p85alpha by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoMCE
PC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX7F91PubMed
LigandPNGBDBM50579634(CHEMBL4860369)copy SMILES
Affinity DataKi:  0.370nMAssay Description:Inhibition of human PI3K p110beta/p85alpha by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX7F91PubMed
LigandPNGBDBM50145416(GSK2126458 | Omipalisib)copy SMILEScopy InChI
Affinity DataKi:  0.530nMAssay Description:Inhibition of human p110beta/p85alpha using PIP2 as substrate in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3QZ4PubMed
LigandPNGBDBM207236(US9260439, 213)copy SMILEScopy InChI
Affinity DataKi:  0.790nMAssay Description:Inhibition of recombinant human PI3K p110beta/p85alpha using phosphatidylinositol 4,5-bisphosphate as substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8RC9PubMed
LigandPNGBDBM50570237(CHEMBL4864407)copy SMILES
Affinity DataKi:  0.940nMAssay Description:Inhibition of human p110beta/p85alpha using PIP2 as substrate in presence of ATP measured by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3QZ4PubMed
LigandPNGBDBM340346(US9758538, Example 34)copy SMILEScopy InChI
Affinity DataKi:  1.70nMAssay Description:Inhibition of recombinant human PI3K p110beta/p85alpha using phosphatidylinositol 4,5-bisphosphate as substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8RC9PubMed
LigandPNGBDBM340314((Scheme A): Preparation of 2,2-difluoroethyl (3S)-...)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Inhibition of recombinant human PI3K p110beta/p85alpha using phosphatidylinositol 4,5-bisphosphate as substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8RC9PubMed
LigandPNGBDBM340391(US9758538, Example 79)copy SMILEScopy InChI
Affinity DataKi:  4nMAssay Description:Inhibition of recombinant human PI3K p110beta/p85alpha using phosphatidylinositol 4,5-bisphosphate as substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8RC9PubMed
LigandPNGBDBM207196(US9260439, 173)copy SMILEScopy InChI
Affinity DataKi:  4.90nMAssay Description:Inhibition of recombinant human PI3K p110beta/p85alpha using phosphatidylinositol 4,5-bisphosphate as substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8RC9PubMed
LigandPNGBDBM340384(US9758538, Example 72)copy SMILEScopy InChI
Affinity DataKi:  5nMAssay Description:Inhibition of recombinant human PI3K p110beta/p85alpha using phosphatidylinositol 4,5-bisphosphate as substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8RC9PubMed
LigandPNGBDBM207234(US9260439, 211)copy SMILEScopy InChI
Affinity DataKi:  6.70nMAssay Description:Inhibition of recombinant human PI3K p110beta/p85alpha using phosphatidylinositol 4,5-bisphosphate as substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8RC9PubMed
LigandPNGBDBM207172(US9260439, 149)copy SMILEScopy InChI
Affinity DataKi:  9.10nMAssay Description:Inhibition of recombinant human PI3K p110beta/p85alpha using phosphatidylinositol 4,5-bisphosphate as substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8RC9PubMed
LigandPNGBDBM340345(US9758538, Example 33)copy SMILEScopy InChI
Affinity DataKi:  11nMAssay Description:Inhibition of recombinant human PI3K p110beta/p85alpha using phosphatidylinositol 4,5-bisphosphate as substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8RC9PubMed
LigandPNGBDBM207028(US9260439, 10 | US9260439, 4)copy SMILEScopy InChI
Affinity DataKi:  13nMAssay Description:Inhibition of recombinant human PI3K p110beta/p85alpha using phosphatidylinositol 4,5-bisphosphate as substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8RC9PubMed
LigandPNGBDBM50336879(2-morpholino-4,5'-bipyrimidin-2'-amine | CHEMBL167...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Inhibition of recombinant human PI3K p110beta/p85alpha using phosphatidylinositol 4,5-bisphosphate as substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8RC9PubMed
LigandPNGBDBM207043(US9260439, 20)copy SMILEScopy InChI
Affinity DataKi:  16nMAssay Description:Inhibition of recombinant human PI3K p110beta/p85alpha using phosphatidylinositol 4,5-bisphosphate as substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8RC9PubMed
LigandPNGBDBM207061(US9260439, 38)copy SMILEScopy InChI
Affinity DataKi:  16nMAssay Description:Inhibition of recombinant human PI3K p110beta/p85alpha using phosphatidylinositol 4,5-bisphosphate as substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8RC9PubMed
LigandPNGBDBM50556948(CHEMBL4742855)copy SMILES
Affinity DataKi:  17nMAssay Description:Inhibition of recombinant human PI3K p110beta/p85alpha using phosphatidylinositol 4,5-bisphosphate as substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8RC9PubMed
LigandPNGBDBM207378(US9260439, 262)copy SMILEScopy InChI
Affinity DataKi:  17nMAssay Description:Inhibition of recombinant human PI3K p110beta/p85alpha using phosphatidylinositol 4,5-bisphosphate as substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8RC9PubMed
LigandPNGBDBM340347(US9758538, Example 35)copy SMILEScopy InChI
Affinity DataKi:  19nMAssay Description:Inhibition of recombinant human PI3K p110beta/p85alpha using phosphatidylinositol 4,5-bisphosphate as substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8RC9PubMed
LigandPNGBDBM207035(US9260439, 12)copy SMILEScopy InChI
Affinity DataKi:  20nMAssay Description:Inhibition of recombinant human PI3K p110beta/p85alpha using phosphatidylinositol 4,5-bisphosphate as substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8RC9PubMed
LigandPNGBDBM207050(US9260439, 27)copy SMILEScopy InChI
Affinity DataKi:  24nMAssay Description:Inhibition of recombinant human PI3K p110beta/p85alpha using phosphatidylinositol 4,5-bisphosphate as substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8RC9PubMed
LigandPNGBDBM207239(US9260439, 216)copy SMILEScopy InChI
Affinity DataKi:  24nMAssay Description:Inhibition of recombinant human PI3K p110beta/p85alpha using phosphatidylinositol 4,5-bisphosphate as substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8RC9PubMed
LigandPNGBDBM207217(US9260439, 194 | US9260439, 238 | US9260439, 239)copy SMILEScopy InChI
Affinity DataKi:  25nMAssay Description:Inhibition of recombinant human PI3K p110beta/p85alpha using phosphatidylinositol 4,5-bisphosphate as substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8RC9PubMed
LigandPNGBDBM207051(US9260439, 28)copy SMILEScopy InChI
Affinity DataKi:  36nMAssay Description:Inhibition of recombinant human PI3K p110beta/p85alpha using phosphatidylinositol 4,5-bisphosphate as substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8RC9PubMed
LigandPNGBDBM50240324(CHEMBL4067552)copy SMILEScopy InChI
Affinity DataKi:  43nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged p110beta/untagged recombinant full length human p85alpha expressed in baculovirus infected Sf2...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87CZ1PubMed
LigandPNGBDBM207391(US9260439, 275)copy SMILEScopy InChI
Affinity DataKi:  46nMAssay Description:Inhibition of recombinant human PI3K p110beta/p85alpha using phosphatidylinositol 4,5-bisphosphate as substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8RC9PubMed
LigandPNGBDBM50451425(CHEMBL4212439)copy SMILEScopy InChI
Affinity DataKi:  49nMAssay Description:Inhibition of p110beta/85alpha (unknown origin) using PIP2 as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F76G4XPubMed
LigandPNGBDBM50240317(CHEMBL4070339)copy SMILEScopy InChI
Affinity DataKi:  54nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged p110beta/untagged recombinant full length human p85alpha expressed in baculovirus infected Sf2...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87CZ1PubMed
LigandPNGBDBM340336(US9758538, Example 24)copy SMILEScopy InChI
Affinity DataKi:  54nMAssay Description:Inhibition of recombinant human PI3K p110beta/p85alpha using phosphatidylinositol 4,5-bisphosphate as substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8RC9PubMed
LigandPNGBDBM50240322(CHEMBL4098032)copy SMILEScopy InChI
Affinity DataKi:  66nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged p110beta/untagged recombinant full length human p85alpha expressed in baculovirus infected Sf2...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87CZ1PubMed
LigandPNGBDBM340352(US9758538, Example 40)copy SMILEScopy InChI
Affinity DataKi:  68nMAssay Description:Inhibition of recombinant human PI3K p110beta/p85alpha using phosphatidylinositol 4,5-bisphosphate as substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8RC9PubMed
LigandPNGBDBM50451427(CHEMBL4212973)copy SMILEScopy InChI
Affinity DataKi:  72nMAssay Description:Inhibition of p110beta/85alpha (unknown origin) using PIP2 as substrate by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F76G4XPubMed
LigandPNGBDBM50564520(CHEMBL4796569)copy SMILES
Affinity DataKi:  89nMAssay Description:Inhibition of N-terminal His6-tagged human recombinant full length PI3Kbeta co-expressed with human recombinant full length P85alpha in baculovirus i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FB56PFPubMed
LigandPNGBDBM50451423(CHEMBL4217392)copy SMILEScopy InChI
Affinity DataKi:  155nMAssay Description:Inhibition of p110beta/85alpha (unknown origin) using PIP2 as substrate by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F76G4XPubMed
LigandPNGBDBM50420714(CHEMBL2087474)copy SMILEScopy InChI
Affinity DataKi:  170nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged p110beta/untagged recombinant full length human p85alpha expressed in baculovirus infected Sf2...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87CZ1PubMed
LigandPNGBDBM50420714(CHEMBL2087474)copy SMILEScopy InChI
Affinity DataKi:  170nMAssay Description:Inhibition of p110beta/85alpha (unknown origin) using PIP2 as substrate by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F76G4XPubMed
LigandPNGBDBM50240326(CHEMBL4068727)copy SMILEScopy InChI
Affinity DataKi:  253nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged p110beta/untagged recombinant full length human p85alpha expressed in baculovirus infected Sf2...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87CZ1PubMed
LigandPNGBDBM50451424(CHEMBL4205584)copy SMILEScopy InChI
Affinity DataKi:  285nMAssay Description:Inhibition of p110beta/85alpha (unknown origin) using PIP2 as substrate by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F76G4XPubMed
LigandPNGBDBM50451426(CHEMBL4208064)copy SMILEScopy InChI
Affinity DataKi:  388nMAssay Description:Inhibition of p110beta/85alpha (unknown origin) using PIP2 as substrate by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F76G4XPubMed
LigandPNGBDBM50240325(CHEMBL4102709)copy SMILEScopy InChI
Affinity DataKi: >490nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged p110beta/untagged recombinant full length human p85alpha expressed in baculovirus infected Sf2...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87CZ1PubMed
LigandPNGBDBM50240320(CHEMBL4088855)copy SMILEScopy InChI
Affinity DataKi: >490nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged p110beta/untagged recombinant full length human p85alpha expressed in baculovirus infected Sf2...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87CZ1PubMed
LigandPNGBDBM50240323(CHEMBL4062315)copy SMILEScopy InChI
Affinity DataKi: >490nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged p110beta/untagged recombinant full length human p85alpha expressed in baculovirus infected Sf2...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87CZ1PubMed
LigandPNGBDBM50240318(CHEMBL4083480)copy SMILEScopy InChI
Affinity DataKi: >490nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged p110beta/untagged recombinant full length human p85alpha expressed in baculovirus infected Sf2...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87CZ1PubMed
LigandPNGBDBM50505306(CHEMBL4531499 | US11534443, Example 49)copy SMILEScopy InChI
Affinity DataIC50: 0.340nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged full-length p110beta/human p85alpha expressed in Sf9 insect cells using PIP2 as substrate by A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q243JRPubMed
LigandPNGBDBM50505302(CHEMBL4527563 | US11534443, Example 44)copy SMILEScopy InChI
Affinity DataIC50: 0.540nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged full-length p110beta/human p85alpha expressed in Sf9 insect cells using PIP2 as substrate by A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q243JRPubMed
LigandPNGBDBM50514590(CHEMBL4440406)copy SMILEScopy InChI
Affinity DataIC50: 0.580nMAssay Description:Inhibition of recombinant human full-length His-tagged p110beta/p85alpha expressed in baculovirus expression system using PIP2 as substrate measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QV3QVSPubMed
LigandPNGBDBM50505304(CHEMBL4450219 | US11534443, Example 59)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged full-length p110beta/human p85alpha expressed in Sf9 insect cells using PIP2 as substrate by A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q243JRPubMed
LigandPNGBDBM50501402(CHEMBL4071605)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full-length human PI3K p110beta/untagged recombinant full length human p85alpha expressed in baculov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7KNJPubMed
LigandPNGBDBM50501399(CHEMBL4100135)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Inhibition of N-terminal His6-tagged recombinant full-length human PI3K p110beta/untagged recombinant full length human p85alpha expressed in baculov...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7KNJPubMed
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