Compile Data Set for Download or QSAR
Found 143 Enz. Inhib. hit(s) with Target = 'Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300972(7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-(py...)copy SMILEScopy InChI
Affinity DataIC50: 4.70nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300964(CHEMBL584270 | rac-7-(6-methoxypyridin-3-yl)-1-(2-...)copy SMILEScopy InChI
Affinity DataIC50: 8.60nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Bos taurus (Bovine))
XUANZHU PHARMA CO., LTD.

US Patent
LigandPNGBDBM235735(US9359371, 3)copy SMILEScopy InChI
Affinity DataIC50: 8.89nMpH: 7.5Assay Description:Method: The test compound or solvent was incubated at 25° C. for 15 min with enzyme solution (0.2 μg/mL) in Tris-HCl buffer of pH 7.5. 100 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BR8R2BUS Patent
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300962(3-(2-ethoxyethylamino)-7-(6-methoxypyridin-3-yl)-1...)copy SMILEScopy InChI
Affinity DataIC50: 9.30nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300953(3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...)copy SMILEScopy InChI
Affinity DataIC50: 9.80nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300970(7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-(py...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50296256(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300987(3-(3-hydroxypropylamino)-7-(6-methoxypyridin-3-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300952(3-(trans-4-hydroxycyclohexylamino)-7-(6-methoxypyr...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300991((R)-3-(2-hydroxypropylamino)-7-(6-methoxypyridin-3...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300983(7-(6-methoxypyridin-3-yl)-3-(2-(4-methylpiperazin-...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300976(2-(7-(6-methoxypyridin-3-yl)-2-oxo-1-(2-propoxyeth...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300989((S)-3-(2-hydroxypropylamino)-7-(6-methoxypyridin-3...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300980(7-(6-methoxypyridin-3-yl)-3-(2-morpholino-2-oxoeth...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300950((S)-3-(1-hydroxypropan-2-ylamino)-7-(6-methoxypyri...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300948((R)-3-(1-hydroxypropan-2-ylamino)-7-(6-methoxypyri...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300951((R)-3-(1-hydroxybutan-2-ylamino)-7-(6-methoxypyrid...)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300971(7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-(py...)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300978(3-(2-(4-hydroxypiperidin-1-yl)-2-oxoethylamino)-7-...)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300960(3-(2-hydroxyethylamino)-7-(6-methoxypyridin-3-yl)-...)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM480487(US10626113, Compound D | US10899756, Compound D)copy SMILEScopy InChI
Affinity DataIC50: 30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KH0SFD
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM480487(US10626113, Compound D | US10899756, Compound D)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:A series of dilutions of the test compounds were prepared with 10% DMSO in assay buffer and 5 μl of the dilution was added to a 50 μl react...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RN3C0PUS Patent
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50241831(CHEMBL4062273 | US10626113, Compound M | US1089975...)copy SMILEScopy InChI
Affinity DataIC50: 30.1nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KH0SFD
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50241831(CHEMBL4062273 | US10626113, Compound M | US1089975...)copy SMILEScopy InChI
Affinity DataIC50: 30.1nMAssay Description:A series of dilutions of the test compounds were prepared with 10% DMSO in assay buffer and 5 μl of the dilution was added to a 50 μl react...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RN3C0PUS Patent
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300963(7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-((t...)copy SMILEScopy InChI
Affinity DataIC50: 31nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300969(7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-(py...)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300977(7-(6-methoxypyridin-3-yl)-3-(2-oxo-2-(pyrrolidin-1...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300966(2-(7-(6-methoxypyridin-3-yl)-2-oxo-1-(2-propoxyeth...)copy SMILEScopy InChI
Affinity DataIC50: 46nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300990((R)-3-(2-hydroxypropylamino)-7-(6-methoxypyridin-3...)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300988((S)-3-(2-hydroxypropylamino)-7-(6-methoxypyridin-3...)copy SMILEScopy InChI
Affinity DataIC50: 52nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300985(3-(2-(4-ethylpiperazin-1-yl)-2-oxoethylamino)-7-(6...)copy SMILEScopy InChI
Affinity DataIC50: 56nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300961(3-(2-ethoxyethylamino)-7-(6-methoxypyridin-3-yl)-1...)copy SMILEScopy InChI
Affinity DataIC50: 57nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50238860(CHEMBL4099219)copy SMILEScopy InChI
Affinity DataIC50: 58nMAssay Description:Inhibition of PDE6A (484 to 817 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]cGMP or [3H]cAMP as substrate after 15 m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N25NFPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Bos taurus (Bovine))
XUANZHU PHARMA CO., LTD.

US Patent
LigandPNGBDBM235755(US9359371, 38)copy SMILEScopy InChI
Affinity DataIC50: 58nMpH: 7.5Assay Description:Method: The test compound or solvent was incubated at 25° C. for 15 min with enzyme solution (0.2 μg/mL) in Tris-HCl buffer of pH 7.5. 100 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BR8R2BUS Patent
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Bos taurus (Bovine))
XUANZHU PHARMA CO., LTD.

US Patent
LigandPNGBDBM235742(US9359371, 11)copy SMILEScopy InChI
Affinity DataIC50: 61nMpH: 7.5Assay Description:Method: The test compound or solvent was incubated at 25° C. for 15 min with enzyme solution (0.2 μg/mL) in Tris-HCl buffer of pH 7.5. 100 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BR8R2BUS Patent
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50296257(7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...)copy SMILEScopy InChI
Affinity DataIC50: 62nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300947((R)-3-(1-hydroxypropan-2-ylamino)-7-(6-methoxypyri...)copy SMILEScopy InChI
Affinity DataIC50: 63nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300949((S)-3-(1-hydroxypropan-2-ylamino)-7-(6-methoxypyri...)copy SMILEScopy InChI
Affinity DataIC50: 68nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300982(7-(6-methoxypyridin-3-yl)-3-(2-(4-methylpiperazin-...)copy SMILEScopy InChI
Affinity DataIC50: 80nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300968(2-(7-(6-methoxypyridin-3-yl)-2-oxo-1-(2-propoxyeth...)copy SMILEScopy InChI
Affinity DataIC50: 87nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300974(2-(7-(6-methoxypyridin-3-yl)-2-oxo-1-(2-propoxyeth...)copy SMILEScopy InChI
Affinity DataIC50: 87nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300984(3-(2-(4-ethylpiperazin-1-yl)-2-oxoethylamino)-7-(6...)copy SMILEScopy InChI
Affinity DataIC50: 99nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300981(7-(6-methoxypyridin-3-yl)-3-(2-oxo-2-(piperazin-1-...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50241837(CHEMBL4102913 | US10626113, Compound G | US1089975...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:A series of dilutions of the test compounds were prepared with 10% DMSO in assay buffer and 5 μl of the dilution was added to a 50 μl react...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RN3C0PUS Patent
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50241837(CHEMBL4102913 | US10626113, Compound G | US1089975...)copy SMILEScopy InChI
Affinity DataIC50: 100nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KH0SFD
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300979(7-(6-methoxypyridin-3-yl)-3-(2-morpholino-2-oxoeth...)copy SMILEScopy InChI
Affinity DataIC50: 114nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300959(3-(2-hydroxyethylamino)-7-(6-methoxypyridin-3-yl)-...)copy SMILEScopy InChI
Affinity DataIC50: 114nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300975(2-(7-(6-methoxypyridin-3-yl)-2-oxo-1-(2-propoxyeth...)copy SMILEScopy InChI
Affinity DataIC50: 115nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50300986(3-(3-hydroxypropylamino)-7-(6-methoxypyridin-3-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 124nMAssay Description:Inhibition of PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41RHVPubMed
TargetRod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha(Bos taurus (Bovine))
XUANZHU PHARMA CO., LTD.

US Patent
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)copy SMILEScopy InChI
Affinity DataIC50: 140nMAssay Description:Inhibition of bovine retina PDE6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28P60KWPubMed
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