TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma L.P.
Curated by ChEMBL
Purdue Pharma L.P.
Curated by ChEMBL
Affinity DataIC50: 2.80nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma L.P.
Curated by ChEMBL
Purdue Pharma L.P.
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma L.P.
Curated by ChEMBL
Purdue Pharma L.P.
Curated by ChEMBL
Affinity DataIC50: 3.5nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma L.P.
Curated by ChEMBL
Purdue Pharma L.P.
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:In vitro inhibition of [14C]- guanidinium influx in Chinese hamster ovary (CHO) cells expressing rat brain sodium channel type IIA (CNaIIA-1)More data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma L.P.
Curated by ChEMBL
Purdue Pharma L.P.
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Institut Henri Beaufour
Curated by ChEMBL
Institut Henri Beaufour
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma L.P.
Curated by ChEMBL
Purdue Pharma L.P.
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma L.P.
Curated by ChEMBL
Purdue Pharma L.P.
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of Na+ influx in chinese hamster ovary cells expressing rat brain sodium channel type IIAMore data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Institut Henri Beaufour
Curated by ChEMBL
Institut Henri Beaufour
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Institut Henri Beaufour
Curated by ChEMBL
Institut Henri Beaufour
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma L.P.
Curated by ChEMBL
Purdue Pharma L.P.
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Institut Henri Beaufour
Curated by ChEMBL
Institut Henri Beaufour
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Institut Henri Beaufour
Curated by ChEMBL
Institut Henri Beaufour
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma L.P.
Curated by ChEMBL
Purdue Pharma L.P.
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Institut Henri Beaufour
Curated by ChEMBL
Institut Henri Beaufour
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Institut Henri Beaufour
Curated by ChEMBL
Institut Henri Beaufour
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma L.P.
Curated by ChEMBL
Purdue Pharma L.P.
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma L.P.
Curated by ChEMBL
Purdue Pharma L.P.
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Inhibition of rat NaV1.2 channelMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma L.P.
Curated by ChEMBL
Purdue Pharma L.P.
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma L.P.
Curated by ChEMBL
Purdue Pharma L.P.
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma L.P.
Curated by ChEMBL
Purdue Pharma L.P.
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Displacement of [3H]batrachotoxinin from rat sodium channel type 2A subunit expressed in CHO-CNa2A cells by whole cell patch clamp techniqueMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma L.P.
Curated by ChEMBL
Purdue Pharma L.P.
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma L.P.
Curated by ChEMBL
Purdue Pharma L.P.
Curated by ChEMBL
Affinity DataIC50: 51nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma L.P.
Curated by ChEMBL
Purdue Pharma L.P.
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:In vitro inhibition of [14C]- guanidinium influx in Chinese hamster ovary (CHO) cells expressing rat brain sodium channel type IIA (CNaIIA-1)More data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma L.P.
Curated by ChEMBL
Purdue Pharma L.P.
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:In vitro inhibition of [14C]- guanidinium influx in Chinese hamster ovary (CHO) cells expressing rat brain sodium channel type IIA (CNaIIA-1)More data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma L.P.
Curated by ChEMBL
Purdue Pharma L.P.
Curated by ChEMBL
Affinity DataIC50: 63nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Institut Henri Beaufour
Curated by ChEMBL
Institut Henri Beaufour
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Institut Henri Beaufour
Curated by ChEMBL
Institut Henri Beaufour
Curated by ChEMBL
Affinity DataIC50: 76nMAssay Description:In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membraneMore data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Institut Henri Beaufour
Curated by ChEMBL
Institut Henri Beaufour
Curated by ChEMBL
Affinity DataIC50: 86nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Institut Henri Beaufour
Curated by ChEMBL
Institut Henri Beaufour
Curated by ChEMBL
Affinity DataIC50: 95nMAssay Description:Inhibitory concentration against [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in vitro in rat cerebral cortex membrane at ...More data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma L.P.
Curated by ChEMBL
Purdue Pharma L.P.
Curated by ChEMBL
Affinity DataIC50: 98nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Institut Henri Beaufour
Curated by ChEMBL
Institut Henri Beaufour
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma L.P.
Curated by ChEMBL
Purdue Pharma L.P.
Curated by ChEMBL
Affinity DataIC50: 105nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma L.P.
Curated by ChEMBL
Purdue Pharma L.P.
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Sodium channel block, determined by % block of [14C]guanidinium flux in CHO line expressing rat type IIA sodium channels derived from rat brainMore data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Institut Henri Beaufour
Curated by ChEMBL
Institut Henri Beaufour
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of veratridine-induced depolarization in rat cerebrocortical synaptosomes using the voltage sensitive fluorescent dye Rhodamine 6GMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma L.P.
Curated by ChEMBL
Purdue Pharma L.P.
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Sodium channel block, determined by % block of [14C]guanidinium flux in CHO line expressing rat type IIA sodium channels derived from rat brainMore data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Institut Henri Beaufour
Curated by ChEMBL
Institut Henri Beaufour
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of veratridine-induced depolarization in rat cerebrocortical synaptosomes using the voltage sensitive fluorescent dye Rhodamine 6GMore data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Institut Henri Beaufour
Curated by ChEMBL
Institut Henri Beaufour
Curated by ChEMBL
Affinity DataIC50: 134nMAssay Description:Inhibitory effect against veratridine-induced glutamate release from rat brain slicesMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma L.P.
Curated by ChEMBL
Purdue Pharma L.P.
Curated by ChEMBL
Affinity DataIC50: 138nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK-293 cells at -130 to -110 mV holding potential by whole-cell voltage clamp analysisMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma L.P.
Curated by ChEMBL
Purdue Pharma L.P.
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Sodium channel block, determined by % block of [14C]guanidinium flux in CHO line expressing rat type IIA sodium channels derived from rat brainMore data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Institut Henri Beaufour
Curated by ChEMBL
Institut Henri Beaufour
Curated by ChEMBL
Affinity DataIC50: 146nMAssay Description:Concentration required to inhibit [3H]BTX binding to Sodium channel of rat brainMore data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Institut Henri Beaufour
Curated by ChEMBL
Institut Henri Beaufour
Curated by ChEMBL
Affinity DataIC50: 149nMAssay Description:In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membraneMore data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Institut Henri Beaufour
Curated by ChEMBL
Institut Henri Beaufour
Curated by ChEMBL
Affinity DataIC50: 183nMAssay Description:In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membraneMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Purdue Pharma L.P.
Curated by ChEMBL
Purdue Pharma L.P.
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Sodium channel block, determined by % block of [14C]guanidinium flux in CHO line expressing rat type IIA sodium channels derived from rat brainMore data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Institut Henri Beaufour
Curated by ChEMBL
Institut Henri Beaufour
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of veratridine-induced depolarization in rat cerebrocortical synaptosomes using the voltage sensitive fluorescent dye Rhodamine 6GMore data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Institut Henri Beaufour
Curated by ChEMBL
Institut Henri Beaufour
Curated by ChEMBL
Affinity DataIC50: 191nMAssay Description:In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membraneMore data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Institut Henri Beaufour
Curated by ChEMBL
Institut Henri Beaufour
Curated by ChEMBL
Affinity DataIC50: 194nMAssay Description:In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membraneMore data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Institut Henri Beaufour
Curated by ChEMBL
Institut Henri Beaufour
Curated by ChEMBL
Affinity DataIC50: 208nMAssay Description:In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membraneMore data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Institut Henri Beaufour
Curated by ChEMBL
Institut Henri Beaufour
Curated by ChEMBL
Affinity DataIC50: 214nMAssay Description:In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membraneMore data for this Ligand-Target Pair
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Institut Henri Beaufour
Curated by ChEMBL
Institut Henri Beaufour
Curated by ChEMBL
Affinity DataIC50: 214nMAssay Description:In vitro inhibition of [3H]-batrachotoxin binding to neurotoxin site 2 of sodium (Na+) channel in rat cerebral cortex membraneMore data for this Ligand-Target Pair
